213 98 98 2 2 H. S. Koelega Psychological Laboratory University of Utrecht Sorbonnelaan 16 NL-3584 CA Utrecht The Netherlands Abstract The literature on the effects of anxiolytic and hypnotic drugs on performance in tasks requiring sustained attention is confusing. This review is an attempt to evaluate the usefulness of vigilance tasks in the assessment of adverse effects of benzodiazepines. The long, monotonous, character of these tasks may be more relevant to many tasks performed in everyday life than the short, and often stimulating, tasks commonly employed in test batteries. From 37 available studies, 26 were examined in detail. In young, normal volunteers, vigilance tasks were found to be sensitive, often dose dependently, to the impairing effects of drugs, even in low dose (2.5 mg diazepam). With these subjects the tasks may be successfully used to compare different benzodiazepines with respect to residual activity. Both accuracy and speed of performance appear to be affected. However, in people actually using the drugs (“patients”), adverse effects on performance are usually not found. There is no evidence that benzodiazepines aggravate the vigilance decrement occurring under normal conditions. They do affect overall level of perceptual sensitivity, but show less effects on response criterion. The drugs do not seem to interact with anxiety or sleep quality in their effect on performance, but there are few studies with patients, and the assessment of anziety is not without problems. It is unlikely that impairments in vigilance are simply a byproduct of global, sedative effects, but there is uncertainty regarding measures of general sedation. Developing tolerance with repeated doses has been noted only occasionally, but the opposite of tolerance, aggravated impairment, has also been reported.
Psychopharmacology – Springer Journals
Published: Jun 1, 1989
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera