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Basic Serological TestingComplement Fixation Test (CFT)

Basic Serological Testing: Complement Fixation Test (CFT) [Complement fixation is a process that initiates through the binding of C1 to at least two IgGs or one IgM, triggering the classical pathway to form a membrane attack complex (MAC), and eventually the lysis of the target. This reaction is utilized in clinical testing because complement can lyse any antibody–antigen complexes. Here, the principle, reagents required in addition to the preparation steps and results interpretation for the complement fixation test are explored.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Basic Serological TestingComplement Fixation Test (CFT)

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References (1)

Publisher
Springer International Publishing
Copyright
© Springer International Publishing AG, part of Springer Nature 2018
ISBN
978-3-319-77693-4
Pages
63 –75
DOI
10.1007/978-3-319-77694-1_10
Publisher site
See Chapter on Publisher Site

Abstract

[Complement fixation is a process that initiates through the binding of C1 to at least two IgGs or one IgM, triggering the classical pathway to form a membrane attack complex (MAC), and eventually the lysis of the target. This reaction is utilized in clinical testing because complement can lyse any antibody–antigen complexes. Here, the principle, reagents required in addition to the preparation steps and results interpretation for the complement fixation test are explored.]

Published: May 24, 2018

Keywords: Complement; sRBC; Lyse; Complement fixation; Back titration

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