Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/autophagy-in-cancer-stem-progenitor-cells-UR9eOkPWyz
References (58)
-
E. Firat, A. Weyerbrock, Simone Gaedicke, A. Grosu, G. Niedermann (2012)
Chloroquine or Chloroquine-PI3K/Akt Pathway Inhibitor Combinations Strongly Promote γ-Irradiation-Induced Cell Death in Primary Stem-Like Glioma CellsPLoS ONE, 7
-
Zidong Li, Bo Chen, Yiqing Wu, F. Jin, Yongjing Xia, Xiangjun Liu (2010)
Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumorsBMC Cancer, 10
-
Teng Jiang, Jin-Tai Yu, Xi-Chen Zhu, Huifu Wang, M. Tan, Lei Cao, Qiao‐quan Zhang, Li Gao, Jian-Quan Shi, Yingdong Zhang, L. Tan (2014)
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagyBritish Journal of Pharmacology, 171
-
Intissar Akalay, B. Janji, M. Hasmim, M. Noman, F. André, P. Crémoux, P. Bertheau, C. Badoual, P. Vielh, A. Larsen, M. Sabbah, T. Tan, Joan Keira, Nicole Hung, J. Thiery, F. Mami-Chouaib, S. Chouaib (2013)
Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis.Cancer research, 73 8
-
Yao-dong Zhao, Qiang Huang, Ji-cheng Yang, M. Lou, Ai-dong Wang, Jun Dong, Zhenghong Qin, Tianyi Zhang (2010)
Autophagy impairment inhibits differentiation of glioma stem/progenitor cellsBrain Research, 1313
-
S. Galavotti, S. Bartesaghi, D. Faccenda, M. Shaked-Rabi, S. Sanzone, A. McEvoy, D. Dinsdale, F. Condorelli, S. Brandner, M. Campanella, R. Grose, Chris Jones, P. Salomoni (2013)
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cellsOncogene, 32
-
Wenzhuo Zhuang, Bingzong Li, Lin-mei Long, Lie-song Chen, Qiang Huang, Zhongqin Liang (2011)
Induction of autophagy promotes differentiation of glioma‐initiating cells and their radiosensitivityInternational Journal of Cancer, 129
-
Xin-hong Huang, Hong-min Bai, Liang Chen, Bin Li, Yi-cheng Lu (2010)
Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumorsJournal of Clinical Neuroscience, 17
-
Yutaka Ueda, Fan-Yan Wei, T. Hide, H. Michiue, Kentaro Takayama, T. Kaitsuka, Hideo Nakamura, K. Makino, J. Kuratsu, S. Futaki, K. Tomizawa (2012)
Induction of autophagic cell death of glioma-initiating cells by cell-penetrating D-isomer peptides consisting of Pas and the p53 C-terminus.Biomaterials, 33 35
-
W. Liu, Ping Huang, Niladri Kar, M. Burgett, Gaelle Muller-Greven, A. Nowacki, C. Distelhorst, J. Lathia, J. Rich, J. Kappes, C. Gladson (2013)
Lyn Facilitates Glioblastoma Cell Survival under Conditions of Nutrient Deprivation by Promoting AutophagyPLoS ONE, 8
-
P. Futreal, P. Söderkvist, P. Söderkvist, P. Söderkvist, J. Marks, J. Iglehart, C. Cochran, J. Barrett, R. Wiseman (1992)
Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms.Cancer research, 52 9
-
J. Wolf, D. Dewi, J. Fredebohm, K. Müller-Decker, C. Flechtenmacher, J. Hoheisel, M. Boettcher (2013)
A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotypeBreast Cancer Research : BCR, 15
-
Stephanie Lomonaco, S. Finniss, Cunli Xiang, A. deCarvalho, F. Umansky, S. Kalkanis, T. Mikkelsen, C. Brodie (2009)
The induction of autophagy by γ‐radiation contributes to the radioresistance of glioma stem cellsInternational Journal of Cancer, 125
-
Ljubica Harhaji-Trajković, U. Vilimanovich, T. Kravić-Stevović, V. Bumbasirevic, V. Trajković (2009)
AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cellsJournal of Cellular and Molecular Medicine, 13
-
B. Gan, Ergun Sahin, Shan Jiang, A. Sánchez-Aguilera, K. Scott, L. Chin, David Williams, D. Kwiatkowski, R. DePinho (2008)
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilizationProceedings of the National Academy of Sciences, 105
-
M. Francipane, E. Lagasse (2013)
Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1Oncotarget, 4
-
Monika Mortensen, E. Soilleux, G. Djordjević, Rebecca Tripp, Michael Lutteropp, E. Sadighi-Akha, Amanda Stranks, Julie Glanville, S. Knight, S. Jacobsen, Kamil Kranc, A. Simon (2011)
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenanceThe Journal of Experimental Medicine, 208
-
Mei Zeng, Jiang-Ning Zhou (2008)
Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells.Cellular signalling, 20 4
-
C. Oliveras‐Ferraros, A. Vázquez-Martín, E. Cuyás, Bruna Corominas-Faja, E. Rodríguez-Gallego, S. Fernández-Arroyo, B. Martín-Castillo, J. Joven, Javierabel MENENDEZ (2014)
Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profileCell Cycle, 13
-
M. Chaterjee, K. Golen (2011)
Breast Cancer Stem Cells Survive Periods of Farnesyl-Transferase Inhibitor-Induced Dormancy by Undergoing AutophagyBone Marrow Research, 2011
-
Fei Liu, Jae Lee, Huijun Wei, Osamu Tanabe, J. Engel, S. Morrison, J. Guan (2010)
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.Blood, 116 23
-
Jae Lee, Daisuke Nakada, Omer Yilmaz, Z. Tothova, N. Joseph, M. Lim, D. Gilliland, S. Morrison (2010)
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.Cell stem cell, 7 5
-
Hong Jiang, C. Gomez-Manzano, H. Aoki, H. Aoki, M. Alonso, S. Kondo, F. McCormick, Jing Xu, Y. Kondo, B. Bekele, H. Colman, F. Lang, J. Fueyo (2007)
Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death.Journal of the National Cancer Institute, 99 18
-
Zhenyu Yue, Shengkan Jin, Ching-Pa Yang, A. Levine, N. Heintz (2003)
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressorProceedings of the National Academy of Sciences of the United States of America, 100
-
斉藤 広子 (1994)
Detailed Deletion Mapping of Chromosome 17q in Ovarian and Breast Cancers : 2-cM Region on 17q 21.3 Often and Commonly Deleted in Tumors -
Jun Sunayama, Ken‐ichiro Matsuda, A. Sato, K. Tachibana, Kaori Suzuki, Y. Narita, S. Shibui, K. Sakurada, T. Kayama, A. Tomiyama, C. Kitanaka (2010)
Crosstalk Between the PI3K/mTOR and MEK/ERK Pathways Involved in the Maintenance of Self‐Renewal and Tumorigenicity of Glioblastoma Stem‐Like CellsSTEM CELLS, 28
-
Fei Liu, J. Guan (2011)
FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesisAutophagy, 7
-
Wen-juan Wang, Lin-mei Long, N. Yang, Qing-qing Zhang, Wen-jun Ji, Jiang-hu Zhao, Zheng-Hong Qin, Zhong Wang, Gang Chen, Zhong-Qin Liang (2013)
NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro, 34
-
Cecilia Sanchez, P. Penfornis, A. Oskowitz, A. Boonjindasup, David Cai, S. Dhule, B. Rowan, A. Kelekar, D. Krause, R. Pochampally (2011)
Activation of autophagy in mesenchymal stem cells provides tumor stromal support.Carcinogenesis, 32 7
-
WZ Zhuang, LM Long, WJ Ji, ZQ Liang (2011)
Rapamycin induces differentiation of glioma stem/progenitor cells by activating autophagyChin J Cancer, 30
-
Wenzhuo Zhuang, Bingzong Li, Lin-mei Long, Lie-song Chen, Qiang Huang, Zhong-Qin Liang (2011)
Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagyBrain Research, 1371
-
Hui-ze Pan, N. Cai, Mo Li, Guang-Hui Liu, J. Belmonte (2013)
Autophagic control of cell ‘stemness’EMBO Molecular Medicine, 5
-
T. Mai, J. Moon, YeonWoo Song, Pham Viet, Pham Phuc, Jung Lee, Tae-Hoo Yi, M. Cho, S. Cho (2012)
Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells.Cancer letters, 321 2
-
Altaf Mohammed, N. Janakiram, Misty Brewer, Rebekah Ritchie, Anuj Marya, S. Lightfoot, V. Steele, C. Rao (2013)
Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling.Translational oncology, 6 6
-
S. Gurumurthy, Stephanie Xie, Brinda Alagesan, Judith Kim, R. Yusuf, B. Saez, A. Tzatsos, Fatih Ozsolak, P. Milos, F. Ferrari, P. Park, O. Shirihai, D. Scadden, N. Bardeesy (2010)
The Lkb1 metabolic sensor maintains haematopoietic stem cell survivalNature, 468
-
Xi Yang, Guang-cui He, Y. Gong, B. Zheng, Fangfang Shi, R. Shi, Xiao Yang (2014)
Mammalian target of rapamycin inhibitor rapamycin enhances anti‐leukemia effect of imatinib on Ph+ acute lymphoblastic leukemia cellsEuropean Journal of Haematology, 92
-
C. Bellodi, M. Lidonnici, A. Hamilton, G. Helgason, A. Soliera, M. Ronchetti, S. Galavotti, K. Young, Tommaso Selmi, R. Yacobi, R. Etten, N. Donato, A. Hunter, D. Dinsdale, E. Tirrò, P. Vigneri, P. Nicotera, M. Dyer, T. Holyoake, P. Salomoni, K. Funai, Haowei Song, L. Yin, I. Lodhi, Xiaochao Wei, J. Yoshino, T. Coleman, C. Semenkovich, Aldo Roccaro, A. Sacco, P. Maiso, A. Azab, Y. Tai, M. Reagan, F. Azab, L. Flores, F. Campigotto, E. Weller, K. Anderson, D. Scadden, I. Ghobrial, S. Ramachandrappa, Anne Raimondo, A. Calí, J. Keogh, E. Henning, Sadia Saeed, A. Thompson, Sumedha Garg, Elena Bochukova, S. Brage, Victoria Trowse, E. Wheeler, Adrienne Sullivan, M. Dattani, Peter Clayton, V. Datta, J. Bruning, N. Wareham, S. O’Rahilly, D. Peet, I. Barroso, M. Whitelaw, S. Farooqi (2009)
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.The Journal of clinical investigation, 119 5
-
D. Soranna, L. Scotti, A. Zambon, C. Bosetti, G. Grassi, A. Catapano, C. Vecchia, G. Mancia, G. Corrao (2012)
Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis.The oncologist, 17 6
-
S. Cufí, A. Vázquez-Martín, C. Oliveras‐Ferraros, B. Martín-Castillo, L. Vellon, J. Menéndez (2011)
Autophagy positively regulates the CD44+CD24-/low breast cancer stem-like phenotypeCell Cycle, 10
-
Hui Zhang, Chun Gao, Long Fang, Hong-chuan Zhao, S. Yao (2013)
Metformin and reduced risk of hepatocellular carcinoma in diabetic patients: a meta-analysisScandinavian Journal of Gastroenterology, 48
-
Yu-jiao Song, Shan-shan Zhang, Xian-ling Guo, K. Sun, Zhipeng Han, Rong Li, Qiu-dong Zhao, Wei-jie Deng, Xuqin Xie, Jian-wei Zhang, Mengchao Wu, Li-xin Wei (2013)
Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment.Cancer letters, 339 1
-
P. Maycotte, Suraj Aryal, C. Cummings, J. Thorburn, M. Morgan, A. Thorburn (2012)
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagyAutophagy, 8
-
A. Balić, Morten Sørensen, S. Trabulo, B. Sáinz, M. Cioffi, C. Vieira, I. Miranda-Lorenzo, M. Hidalgo, J. Kleeff, M. Erkan, C. Heeschen (2014)
Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog SignalingMolecular Cancer Therapeutics, 13
-
J. Wiesner, R. Ortmann, H. Jomaa, M. Schlitzer (2004)
New Antimalarial DrugsChemInform, 35
-
E. Filippi-Chiela, E. Villodre, L. Zamin, G. Lenz (2011)
Autophagy Interplay with Apoptosis and Cell Cycle Regulation in the Growth Inhibiting Effect of Resveratrol in Glioma CellsPLoS ONE, 6
-
V. Espina, B. Mariani, Rosa Gallagher, K. Tran, S. Banks, J. Wiedemann, Heather Huryk, Claudius Mueller, Luana Adamo, Jianghong Deng, E. Petricoin, Lucia Pastore, S. Zaman, Geetha Menezes, James Mize, J. Johal, K. Edmiston, L. Liotta (2010)
Malignant Precursor Cells Pre-Exist in Human Breast DCIS and Require Autophagy for SurvivalPLoS ONE, 5
-
Piyush Gupta, T. Onder, G. Jiang, Kai Tao, C. Kuperwasser, R. Weinberg, E. Lander (2009)
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput ScreeningCell, 138
-
D. Choi, Elvin Blanco, Yoo-shin Kim, Angel Rodriguez, Hong Zhao, T. Huang, Chun-Liang Chen, G. Jin, M. Landis, Lacey Burey, W. Qian, S. Granados, B. Dave, H. Wong, M. Ferrari, Stephen Wong, Jenny Chang (2014)
Chloroquine Eliminates Cancer Stem Cells Through Deregulation of Jak2 and DNMT1STEM CELLS, 32
-
Zhong鄄 Liang, Wen鄄 Zhuang, Mei Lin鄄, Wen鄄 Long, Ji Jun
Chinese Anti鄄 Cancer a Ssociation -
Chong Chen, Yu Liu, Runhua Liu, T. Ikenoue, Kunliang Guan, Yang Liu, P. Zheng (2008)
TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen speciesThe Journal of Experimental Medicine, 205
-
W. Yue, A. Hamaï, G. Tonelli, C. Bauvy, V. Nicolas, H. Tharinger, P. Codogno, M. Mehrpour (2013)
Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenanceAutophagy, 9
-
X. Qu, Jie Yu, G. Bhagat, Norihiko Furuya, H. Hibshoosh, A. Troxel, J. Rosen, E. Eskelinen, N. Mizushima, Y. Ohsumi, G. Cattoretti, B. Levine (2003)
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.The Journal of clinical investigation, 112 12
-
C. Gong, C. Gong, C. Bauvy, C. Bauvy, G. Tonelli, G. Tonelli, W. Yue, W. Yue, C. Deloménie, Valérie Nicolas, Yinghui Zhu, V. Domergue, V. Marin-Esteban, V. Marin-Esteban, H. Tharinger, L. Delbos, H. Gary-Gouy, A. Morel, S. Ghavami, E. Song, P. Codogno, P. Codogno, M. Mehrpour, M. Mehrpour (2012)
Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cellsOncogene, 32
-
W. Janzen, Paul Bernasconi (2002)
High Throughput ScreeningMethods in molecular biology, 565
-
Zheng Wang, S. Lai, L. Xie, Jian-dong Zhao, N. Ma, Ji Zhu, Z. Ren, G. Jiang (2014)
Metformin is associated with reduced risk of pancreatic cancer in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.Diabetes research and clinical practice, 106 1
-
K. Rothe, Hanyang Lin, Kevin Lin, A. Leung, Hui Wang, Mehrnoush Malekesmaeili, R. Brinkman, D. Forrest, S. Gorski, Xiaoyan Jiang (2014)
The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells.Blood, 123 23
-
K Rothe, H Lin, KB Lin, A Leung, HM Wang, M Malekesmaeili, RR Brinkman, DL Forrest, SM Gorski, X Jiang (2014)
Identification of the core autophagy protein ATG4B as a potential biomarker and therapeutic target in CML stem/progenitor cellsBlood
-
Stephanie Lomonaco, S. Finniss, Cunli Xiang, H. Lee, Wei Jiang, N. Lemke, S. Rempel, T. Mikkelsen, C. Brodie (2011)
Cilengitide induces autophagy-mediated cell death in glioma cells.Neuro-oncology, 13 8
- Publisher
- Springer Journals
- Copyright
- Copyright © 2015 by Springer-Verlag Berlin Heidelberg
- Subject
- Medicine & Public Health; Oncology; Pharmacology/Toxicology; Cancer Research
- ISSN
- 0344-5704
- eISSN
- 1432-0843
- DOI
- 10.1007/s00280-014-2634-2
- pmid
- 25424280
- Publisher site
- See Article on Publisher Site
Abstract
Macroautophagy is widely accepted as a cytoprotective mechanism against various environmental stresses. While inhibition of autophagy is generally considered to increase the susceptibility of cancer cells to therapeutic agents, whether it also plays a similar role in tumor stem cells is unclear and still controversial. With increased attention and efforts focused on the cytoprotective feature of autophagy in cancer, it is also essential to understand its role in the biology of cancer stem cells, including self-renewal, differentiation, and tumorigenicity. Although there are very few studies that evaluate autophagy in cancer stem/progenitor cells, understanding the mechanisms governing autophagic responses in various cancer stem cells could provide support for the future development of clinical therapeutics. The present review summarizes current studies that assess the role of autophagy in various types of cancer stem cells and those that evaluate the application of inhibitors of key components within the autophagy pathway in cancer stem/progenitor cells.
Journal
Cancer Chemotherapy and Pharmacology – Springer Journals
Published: May 1, 2015