Attenuation by haloperidol of place preference conditioning using food reinforcement

Attenuation by haloperidol of place preference conditioning using food reinforcement 213 77 77 4 4 C. Spyraki H. C. Fibiger A. G. Phillips Division of Neurological Sciences, Department of Psychiatry and Department of Psychology University of British Columbia V6T 1W5 Vancouver B.C. Canada Abstract The place preference conditioning paradigm was used to examine the reinforcing properties of food in hungry rats. Availability of food in one of two distinctive environments increased the amount of time they spent in the environment associated with food in a test when the animals were no longer food deprived and neither environment contained food. Pretreatment with haloperidol (0.1 or 0.2 mg/kg) during the conditioning phase blocked the establishment of place preference even though the animals consumed the food in the drugged state. The results are interpreted as demonstrating a role for dopamine-containing neurons in mediating the reinforcing properties of food. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Attenuation by haloperidol of place preference conditioning using food reinforcement

Psychopharmacology, Volume 77 (4) – Aug 1, 1982

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Publisher
Springer Journals
Copyright
Copyright © 1982 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00432775
Publisher site
See Article on Publisher Site

Abstract

213 77 77 4 4 C. Spyraki H. C. Fibiger A. G. Phillips Division of Neurological Sciences, Department of Psychiatry and Department of Psychology University of British Columbia V6T 1W5 Vancouver B.C. Canada Abstract The place preference conditioning paradigm was used to examine the reinforcing properties of food in hungry rats. Availability of food in one of two distinctive environments increased the amount of time they spent in the environment associated with food in a test when the animals were no longer food deprived and neither environment contained food. Pretreatment with haloperidol (0.1 or 0.2 mg/kg) during the conditioning phase blocked the establishment of place preference even though the animals consumed the food in the drugged state. The results are interpreted as demonstrating a role for dopamine-containing neurons in mediating the reinforcing properties of food.

Journal

PsychopharmacologySpringer Journals

Published: Aug 1, 1982

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