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Association between parental bipolar disorder and increased risk of exposure to prescription opioids for their offspring

Association between parental bipolar disorder and increased risk of exposure to prescription... PurposeIndividuals with bipolar disorder (BD) may have an increased risk of exposure to prescription opioids. However, it is still unknown whether such risk also occurs in their offspring. This study aimed to investigate the risk of exposure to prescription opioid use and related medical conditions in the offspring of parents with BD.MethodsThis study used the Taiwan National Health Research Database and included offspring who had any parent with a diagnosis of BD. The matched-control cohort was randomly identified from the offspring of parents without any major psychiatric disorders (MPD). We identified data pertaining to opioid prescription and related medical conditions, namely pain disorder, malignancy, autoimmune disease, and arthropathy. The Poisson regression was used to estimate odds ratios and 95% confidence intervals.ResultsIn total, 11,935 offspring of parents with BD and 119,350 offspring of parents without any MPD were included. After controlling for demographics and mental disorders, offspring of parents with BD demonstrated higher rates of prescription opioid use than those of parents without MPD, especially the intravenous/intramuscular form of opioids and prescription in hospital settings. In addition, offspring of parents with BD had a higher odds of pain disorders than those of parents without MPD.ConclusionOur study identifies a higher odd for developing pain disorders and exposure to prescription opioids among children of parents with BD. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Social Psychiatry and Psychiatric Epidemiology Springer Journals

Association between parental bipolar disorder and increased risk of exposure to prescription opioids for their offspring

Li, Dian-Jeng; Chen, Mu-Hong; Bai, Ya-Mei; Tsai, Shih-Jen; Cheng, Chih-Ming; Su, Tung-Ping; Chen, Tzeng-Ji; Yeh, Ta-Chuan; Liang, Chih-Sung
Social Psychiatry and Psychiatric Epidemiology , Volume 58 (2) – Feb 1, 2023
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References (51)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0933-7954
eISSN
1433-9285
DOI
10.1007/s00127-022-02360-5
Publisher site
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Abstract

PurposeIndividuals with bipolar disorder (BD) may have an increased risk of exposure to prescription opioids. However, it is still unknown whether such risk also occurs in their offspring. This study aimed to investigate the risk of exposure to prescription opioid use and related medical conditions in the offspring of parents with BD.MethodsThis study used the Taiwan National Health Research Database and included offspring who had any parent with a diagnosis of BD. The matched-control cohort was randomly identified from the offspring of parents without any major psychiatric disorders (MPD). We identified data pertaining to opioid prescription and related medical conditions, namely pain disorder, malignancy, autoimmune disease, and arthropathy. The Poisson regression was used to estimate odds ratios and 95% confidence intervals.ResultsIn total, 11,935 offspring of parents with BD and 119,350 offspring of parents without any MPD were included. After controlling for demographics and mental disorders, offspring of parents with BD demonstrated higher rates of prescription opioid use than those of parents without MPD, especially the intravenous/intramuscular form of opioids and prescription in hospital settings. In addition, offspring of parents with BD had a higher odds of pain disorders than those of parents without MPD.ConclusionOur study identifies a higher odd for developing pain disorders and exposure to prescription opioids among children of parents with BD.

Journal

Social Psychiatry and Psychiatric Epidemiology – Springer Journals

Published: Feb 1, 2023

Keywords: Bipolar disorder; Prescription opioid; NHIRD; Pain; Substance abuse

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