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Aspirin: recent developments

Aspirin: recent developments Aspirin exerts anti-thrombotic action by acetylating and inactivating cyclooxygenase-1, preventing the production of thromboxane A 2 in platelets. Through this inhibition of platelet function, aspirin is considered as a preventative of ischemic diseases such as coronary and cerebral infarction. However, many studies have revealed that aspirin has other beneficial actions in addition to its anti-platelet activity. For example, aspirin may confer some benefit against colorectal cancer. Here, we discuss the involvement of inflammation in atherosclerosis and how aspirin exerts its beneficial actions in atherosclerotic diseases and cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cellular and Molecular Life Sciences Springer Journals

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References (50)

Publisher
Springer Journals
Copyright
Copyright © 2007 by Birkhaueser
Subject
Life Sciences; Biochemistry, general; Life Sciences, general ; Biomedicine general; Cell Biology
ISSN
1420-682X
eISSN
1420-9071
DOI
10.1007/s00018-007-7449-4
pmid
18038215
Publisher site
See Article on Publisher Site

Abstract

Aspirin exerts anti-thrombotic action by acetylating and inactivating cyclooxygenase-1, preventing the production of thromboxane A 2 in platelets. Through this inhibition of platelet function, aspirin is considered as a preventative of ischemic diseases such as coronary and cerebral infarction. However, many studies have revealed that aspirin has other beneficial actions in addition to its anti-platelet activity. For example, aspirin may confer some benefit against colorectal cancer. Here, we discuss the involvement of inflammation in atherosclerosis and how aspirin exerts its beneficial actions in atherosclerotic diseases and cancer.

Journal

Cellular and Molecular Life SciencesSpringer Journals

Published: Nov 26, 2007

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