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Ask the Editor Journal of Autism and Developmental Disorders, Vol. 27, No. 5, 1997 Question: "I have a child with autism and I want another child. What risk exists for this other child to have autism?" It will depend on the results of the medical investigations carried out on the first child. In a small proportion of cases of autism (up to 10%, but some authors do think it is much higher), autism occurs in conjunction with clear-cut medical disorders which often have a genetic mode of trans- mission themselves. This is particularly true for two disorders: fragile X (which accounts for 2-7% of cases of autism) and tuberous sclerosis (which accounts for 1-3% of cases of autism). If the index child with autism has one of these two medical conditions, there is a greater likelihood that other children would have the same medical disorder. In this instance, the risk of autism would therefore also be raised but the magnitude of the increase is difficult to establish with present knowledge. Genetic counseling in these cases can help to refine the risk estimation. Assuming that medical disorders such as fragile X and tuberous scle- rosis have been ruled out in the index child, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Autism and Developmental Disorders Springer Journals

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Publisher
Springer Journals
Copyright
Copyright © 1997 by Plenum Publishing Corporation
Subject
Psychology; Pediatrics; Clinical Psychology; Developmental Psychology; Neuropsychology
ISSN
0162-3257
eISSN
1573-3432
DOI
10.1023/A:1025894430204
Publisher site
See Article on Publisher Site

Abstract

Journal of Autism and Developmental Disorders, Vol. 27, No. 5, 1997 Question: "I have a child with autism and I want another child. What risk exists for this other child to have autism?" It will depend on the results of the medical investigations carried out on the first child. In a small proportion of cases of autism (up to 10%, but some authors do think it is much higher), autism occurs in conjunction with clear-cut medical disorders which often have a genetic mode of trans- mission themselves. This is particularly true for two disorders: fragile X (which accounts for 2-7% of cases of autism) and tuberous sclerosis (which accounts for 1-3% of cases of autism). If the index child with autism has one of these two medical conditions, there is a greater likelihood that other children would have the same medical disorder. In this instance, the risk of autism would therefore also be raised but the magnitude of the increase is difficult to establish with present knowledge. Genetic counseling in these cases can help to refine the risk estimation. Assuming that medical disorders such as fragile X and tuberous scle- rosis have been ruled out in the index child,

Journal

Journal of Autism and Developmental Disorders – Springer Journals

Published: Sep 8, 2004

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