213 101 101 1 1 P. Whitton G. Curzon Department of Neurochemistry Institute of Neurology Queen Square WC1N 3BG London UK School of Pharmacy Brunswick Square WC1N 1AX London UK Abstract 1-(3-Chlorophenyl) piperazine (mCPP) was previously shown to have an anxiogenic-like effect, i.e., it decreased total interaction in a rat social interaction test. Evidence indicated mediation by activation of 5-HT 1C receptors with an ED 50 of approximately 500 µg/kg IP (Kennett et al. 1989). A comparable effect is now shown on infusing 4 µg of the drug ICV or infusing 0.5 µg into the hippocampus. Both responses were dose dependent. Infusion of 1 µg mCPP into the amygdala had no effect. None of the above treatments significantly reduced locomotion. Results are consistent with the postulated role of the hippocampus in anxiety.
Psychopharmacology – Springer Journals
Published: Mar 1, 1990
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