Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus

Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus 213 101 101 1 1 P. Whitton G. Curzon Department of Neurochemistry Institute of Neurology Queen Square WC1N 3BG London UK School of Pharmacy Brunswick Square WC1N 1AX London UK Abstract 1-(3-Chlorophenyl) piperazine (mCPP) was previously shown to have an anxiogenic-like effect, i.e., it decreased total interaction in a rat social interaction test. Evidence indicated mediation by activation of 5-HT 1C receptors with an ED 50 of approximately 500 µg/kg IP (Kennett et al. 1989). A comparable effect is now shown on infusing 4 µg of the drug ICV or infusing 0.5 µg into the hippocampus. Both responses were dose dependent. Infusion of 1 µg mCPP into the amygdala had no effect. None of the above treatments significantly reduced locomotion. Results are consistent with the postulated role of the hippocampus in anxiety. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus

Psychopharmacology, Volume 101 (1) – Mar 1, 1990

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Publisher
Springer Journals
Copyright
Copyright © 1990 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02245806
Publisher site
See Article on Publisher Site

Abstract

213 101 101 1 1 P. Whitton G. Curzon Department of Neurochemistry Institute of Neurology Queen Square WC1N 3BG London UK School of Pharmacy Brunswick Square WC1N 1AX London UK Abstract 1-(3-Chlorophenyl) piperazine (mCPP) was previously shown to have an anxiogenic-like effect, i.e., it decreased total interaction in a rat social interaction test. Evidence indicated mediation by activation of 5-HT 1C receptors with an ED 50 of approximately 500 µg/kg IP (Kennett et al. 1989). A comparable effect is now shown on infusing 4 µg of the drug ICV or infusing 0.5 µg into the hippocampus. Both responses were dose dependent. Infusion of 1 µg mCPP into the amygdala had no effect. None of the above treatments significantly reduced locomotion. Results are consistent with the postulated role of the hippocampus in anxiety.

Journal

PsychopharmacologySpringer Journals

Published: Mar 1, 1990

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