213 100 100 4 4 F. S. Guimarães T. M. Chiaretti F. G. Graeff A. W. Zuardi Department of Pharmacology Campus of the University of São Paulo BR 14049 Ribeirão Preto SP Brazil Department of Neuropsychiatry FMRP, Campus of the University of São Paulo BR 14049 Ribeirão Preto SP Brazil Laboratory of Psychobiology, FFCLRP Campus of the University of São Paulo BR 14049 Ribeirão Preto SP Brazil Abstract In order to assess the presence of anxiolytic properties in cannabidiol (CBD) the drug was tested in an elevated plus-maze model of anxiety, in rats. Doses of 2.5, 5.0 and 10.0 mg/kg significantly increased the entry ratio (open/total number of entries), an anxiolytic-like effect. CBD at a dose of 20.0 mg/kg was no longer effective. None of the doses of CBD used changed total number of entries, a measure of total exploratory activity. Diazepam (2.0 mg/kg) also caused an anxiolytic-like effect in this model. These results indicate that CBD causes a selective anxiolytic effect in the elevated plusmaze, within a limited range of doses.
Psychopharmacology – Springer Journals
Published: Apr 1, 1990
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