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E. Damme, A. Barre, P. Rougé, F. Leuven, J. Balzarini, W. Peumans (1996)
Molecular cloning of the lectin and a lectin-related protein from common Solomon's seal (Polygonatum multiflorum)Plant Molecular Biology, 31
Bo Liu, Jin-ming Wu, Jing Li, Jun-Jie Liu, Wen-wen Li, Chun-yang Li, H. Xu, J. Bao (2010)
Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways.Biochimie, 92 12
(1992)
Plant lectinsInpharma Weekly, 841
Hao Peng, Hui Lv, Ying Wang, Yan-hong Liu, Chun-yang Li, Liang Meng, Fang Chen, J. Bao (2009)
Clematis montana lectin, a novel mannose-binding lectin from traditional Chinese medicine with antiviral and apoptosis-inducing activitiesPeptides, 30
J. Balzarini, S. Hatse, K. Vermeire, K. Princen, S. Aquaro, C. Perno, E. Clercq, H. Egberink, Guy Mooter, W. Peumans, E. Damme, D. Schols (2004)
Mannose-Specific Plant Lectins from the Amaryllidaceae Family Qualify as Efficient Microbicides for Prevention of Human Immunodeficiency Virus InfectionAntimicrobial Agents and Chemotherapy, 48
Qi-jia Yu, Ziyun Li, S. Yao, M. Ming, Shu-ya Wang, Bo Liu, J. Bao (2011)
In silico Analysis of Molecular Mechanisms of Galanthus nivalis Agglutinin-Related Lectin-Induced Cancer Cell Death from Carbohydrate-Binding Motif Evolution HypothesisApplied Biochemistry and Biotechnology, 165
J. Balzarini (2007)
Carbohydrate-Binding Agents: A Potential Future Cornerstone for the Chemotherapy of Enveloped Viruses?Antiviral Chemistry and Chemotherapy, 18
Toshiyuki Mori, B. O’Keefe, R. Sowder, S. Bringans, R. Gardella, S. Berg, P. Cochran, J. Turpin, R. Buckheit, J. Mcmahon, M. Boyd (2005)
Isolation and Characterization of Griffithsin, a Novel HIV-inactivating Protein, from the Red Alga Griffithsia sp.*Journal of Biological Chemistry, 280
E. Fouquaert, David Smith, W. Peumans, P. Proost, J. Balzarini, S. Savvides, E. Damme (2009)
Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity.Biochemical and biophysical research communications, 380 2
G. Pollakis, Stanley Kang, A. Kliphuis, Moustapha Chalaby, J. Goudsmit, W. Paxton (2001)
N-Linked Glycosylation of the HIV Type-1 gp120 Envelope Glycoprotein as a Major Determinant of CCR5 and CXCR4 Coreceptor Utilization*The Journal of Biological Chemistry, 276
Bo Liu, H. Bian, J. Bao (2010)
Plant lectins: potential antineoplastic drugs from bench to clinic.Cancer letters, 287 1
J Balzarini, K Laethem, S Hatse, M Froeyen, W Peumans, E Damme, D Schols (2005)
Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120: a new therapeutic concept to hit the achilles heel of HIVJ. Biol. Chem., 280
A. Barre, Y. Bourne, E. Damme, W. Peumans, P. Rougé (2001)
Mannose-binding plant lectins: different structural scaffolds for a common sugar-recognition process.Biochimie, 83 7
Wen-wen Li, Jia-ying Yu, H. Xu, J. Bao (2011)
Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics.Biochemical and biophysical research communications, 414 2
G. Snyder, J. Ford, P. Torabi-Parizi, J. Arthos, P. Schuck, M. Colonna, P. Sun (2005)
Characterization of DC-SIGN/R Interaction with Human Immunodeficiency Virus Type 1 gp120 and ICAM Molecules Favors the Receptor's Role as an Antigen-Capturing Rather than an Adhesion ReceptorJournal of Virology, 79
S. Roy, R. Srivastava, S. Shankar (2010)
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancerJournal of Molecular Signaling, 5
D. Huskens, K. Vermeire, E. Vandemeulebroucke, J. Balzarini, D. Schols (2008)
Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent.The international journal of biochemistry & cell biology, 40 12
Jingjin Ding, J. Bao, Deyu Zhu, Ying Zhang, Dacheng Wang (2010)
Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure.Journal of structural biology, 171 3
P. Lozach, A. Amara, B. Bartosch, J. Virelizier, F. Arenzana‐Seisdedos, F. Cosset, R. Altmeyer (2004)
C-type Lectins L-SIGN and DC-SIGN Capture and Transmit Infectious Hepatitis C Virus Pseudotype Particles*Journal of Biological Chemistry, 279
J. Tilton, R. Doms (2010)
Entry inhibitors in the treatment of HIV-1 infection.Antiviral research, 85 1
X. Ji, H. Gewurz, G. Spear (2005)
Mannose binding lectin (MBL) and HIV.Molecular immunology, 42 2
PY Lozach, L Burleigh, I Staropoli, A Amara (2007)
The C type lectins DC-SIGN and L-SIGN: receptors for viral glycoproteinsMethods Mol. Biol., 379
J. Balzarini, J. Neyts, D. Schols, M. Hosoya, Els Damme, W. Peumans, E. Clercq (1992)
The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro.Antiviral research, 18 2
(2004)
Antimicrob. Agents Chemother
L. Fu, Chengying Zhou, S. Yao, Jia-ying Yu, Bo Liu, J. Bao (2011)
Plant lectins: targeting programmed cell death pathways as antitumor agents.The international journal of biochemistry & cell biology, 43 10
Qing Xu, Ying Liu, Xiaochen Wang, H. Gu, Zhang-liang Chen (1998)
Purification and characterization of a novel anti-fungal protein from Gastrodia elataPlant Physiology and Biochemistry, 36
Bo Liu, Yan Cheng, Bo Zhang, H. Bian, J. Bao (2009)
Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway.Cancer letters, 275 1
Xiaochao Xu, Chuanfang Wu, Chao Liu, Yongting Luo, Jian Li, Xinping Zhao, E. Damme, J. Bao (2007)
Purification and characterization of a mannose-binding lectin from the rhizomes of Aspidistra elatior Blume with antiproliferative activity.Acta biochimica et biophysica Sinica, 39 7
E. Damme, Sachiko Nakamura-Tsuruta, David Smith, M. Ongenaert, H. Winter, P. Rougé, I. Goldstein, H. Mo, J. Kominami, R. Culerrier, A. Barre, J. Hirabayashi, W. Peumans (2007)
Phylogenetic and specificity studies of two-domain GNA-related lectins: generation of multispecificity through domain duplication and divergent evolution.The Biochemical journal, 404 1
L. Santarpia, A. El-Naggar, G. Cote, J. Myers, S. Sherman (2008)
Phosphatidylinositol 3-kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer.The Journal of clinical endocrinology and metabolism, 93 1
M. Yee, K. Konopka, J. Balzarini, N. Düzgüneş (2011)
Inhibition of HIV-1 Env-Mediated Cell-Cell Fusion by Lectins, Peptide T-20, and Neutralizing AntibodiesThe Open Virology Journal, 5
Bharathi Yarasi, Vijayakumar Sadumpati, China Immanni, Dasavantha Vudem, V. Khareedu (2008)
Transgenic rice expressing Allium sativum leaf agglutinin (ASAL) exhibits high-level resistance against major sap-sucking pestsBMC Plant Biology, 8
Chun-yang Li, Liang Meng, Bo Liu, J. Bao (2009)
Galanthus nivalis Agglutinin (GNA)-Related Lectins: Traditional Proteins, Burgeoning Drugs?Current Chemical Biology, 3
Bo Liu, Xiaochao Xu, Yan Cheng, Jian Huang, Yan-hong Liu, Zhen Liu, Mingwei Min, H. Bian, Jing Chen, J. Bao (2008)
Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema lectin and chemical modification properties on its mannose-binding sites.BMB reports, 41 5
A. Barre, E. Damme, W. Peumans, P. Rougé (1996)
Structure-Function Relationship of Monocot Mannose-Binding Lectins, 112
J. Downward (2004)
PI 3-kinase, Akt and cell survival.Seminars in cell & developmental biology, 15 2
A. Thorburn (2007)
Apoptosis and autophagy: regulatory connections between two supposedly different processesApoptosis, 13
J. An, Jin-zhi Liu, Chuanfang Wu, Jian Li, Lei Dai, E. Damme, J. Balzarini, E. Clercq, Fang Chen, J. Bao (2006)
Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua.Acta biochimica et biophysica Sinica, 38 2
J. Sacchettini, L. Baum, C. Brewer (2001)
Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction.Biochemistry, 40 10
Zhonghai Chen, Y. Pang, Xiaojun Liu, Xinglong Wang, Z. Deng, Xiaofen Sun, K. Tang (2005)
Molecular cloning and characterization of a novel mannose-binding lectin cDNA from Zantedeschia aethiopica.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al, 29 2
Bo Liu, Hao Peng, Q. Yao, Jing Li, E. Damme, J. Balzarini, J. Bao (2009)
Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities.Phytomedicine : international journal of phytotherapy and phytopharmacology, 16 6-7
Yongting Luo, Xiaochao Xu, Jiwei Liu, Jian Li, Yisheng Sun, Zhen Liu, Jin-zhi Liu, E. Damme, J. Balzarini, J. Bao (2007)
A novel mannose-binding tuber lectin from Typhonium divaricatum (L.) Decne (family Araceae) with antiviral activity against HSV-II and anti-proliferative effect on human cancer cell lines.Journal of biochemistry and molecular biology, 40 3
Suddham Singh, J. Ni, Lai-Xi Wang (2003)
Chemoenzymatic synthesis of high-mannose type HIV-1 gp120 glycopeptides.Bioorganic & medicinal chemistry letters, 13 3
E. Damme, W. Peumans, A. Barre, P. Rougé (1998)
Plant Lectins: A Composite of Several Distinct Families of Structurally and Evolutionary Related Proteins with Diverse Biological RolesCritical Reviews in Plant Sciences, 17
B. O’Keefe, J. Beutler, J. Cardellina, R. Gulakowski, B. Krepps, J. Mcmahon, R. Sowder, L. Henderson, L. Pannell, S. Pomponi, M. Boyd (1997)
Isolation and characterization of niphatevirin, a human-immunodeficiency-virus-inhibitory glycoprotein from the marine sponge Niphates erecta.European journal of biochemistry, 245 1
Jianhong Yao, Y. Pang, H. Qi, Bingliang Wan, Xiuyun Zhao, Weiwen Kong, Xiaofen Sun, K. Tang (2003)
Transgenic Tobacco Expressing Pinellia ternata Agglutinin Confers Enhanced Resistance to AphidsTransgenic Research, 12
Y. Karasaki, S. Tsukamoto, K. Mizusaki, T. Sugiura, S. Gotoh (2001)
A garlic lectin exerted an antitumor activity and induced apoptosis in human tumor cellsFood Research International, 34
C. Sandström, O. Berteau, E. Gemma, S. Oscarson, L. Kenne, A. Gronenborn (2004)
Atomic mapping of the interactions between the antiviral agent cyanovirin-N and oligomannosides by saturation-transfer difference NMR.Biochemistry, 43 44
Antony Dimitrov, J. Louis, C. Bewley, G. Clore, R. Blumenthal (2005)
Conformational changes in HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion and inactivation.Biochemistry, 44 37
G. Férir, D. Huskens, K. Palmer, Daniel Boudreaux, M. Swanson, D. Markovitz, J. Balzarini, D. Schols (2012)
Combinations of griffithsin with other carbohydrate-binding agents demonstrate superior activity against HIV Type 1, HIV Type 2, and selected carbohydrate-binding agent-resistant HIV Type 1 strains.AIDS research and human retroviruses, 28 11
H. Wang, T. Ng, V. Ooi, W. Liu (2000)
Effects of lectins with different carbohydrate-binding specificities on hepatoma, choriocarcinoma, melanoma and osteosarcoma cell lines.The international journal of biochemistry & cell biology, 32 3
(2008)
J. Clin. Endocrinol. Metab
L. Gattegno, Abdelhafid Ramdani, Thierry Jouault, L. Saffar, J. Gluckman (1992)
Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1).AIDS research and human retroviruses, 8 1
Jiwei Liu, Xiaochao Xu, Jin-zhi Liu, J. Balzarini, Yongting Luo, Y. Kong, Jian Li, Fang Chen, E. Damme, J. Bao (2007)
A novel tetrameric lectin from Lycoris aurea with four mannose binding sites per monomer.Acta biochimica Polonica, 54 1
EJM Damme, N Lannoo, WJ Peumans (2008)
Plant lectinsAdv. Bot. Res., 48
Yuichiro Sato, M. Hirayama, K. Morimoto, N. Yamamoto, Satomi Okuyama, K. Hori (2011)
High Mannose-binding Lectin with Preference for the Cluster of α1–2-Mannose from the Green Alga Boodlea coacta Is a Potent Entry Inhibitor of HIV-1 and Influenza Viruses*The Journal of Biological Chemistry, 286
S. Elmore (2007)
Apoptosis: A Review of Programmed Cell DeathToxicologic Pathology, 35
E. Clercq (2002)
New anti‐HIV agents and targetsMedicinal Research Reviews, 22
J. Balzarini (2007)
Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapyNature Reviews. Microbiology, 5
P. Lozach, L. Burleigh, I. Staropoli, A. Amara (2007)
The C Type Lectins DC-SIGN and L-SIGNGlycovirology Protocols, 379
J. Auwerx, K. François, K. Covens, K. Laethem, J. Balzarini (2008)
Glycan deletions in the HIV-1 gp120 V1/V2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention.Virology, 382 1
J. Balzarini, K. Laethem, S. Hatse, M. Froeyen, W. Peumans, E. Damme, D. Schols (2005)
Carbohydrate-binding Agents Cause Deletions of Highly Conserved Glycosylation Sites in HIV GP120Journal of Biological Chemistry, 280
(2013)
Glycoconj J
Zi-ting Zhang, Hao Peng, Chun-yang Li, Jun-Jie Liu, Ting-ting Zhou, Yizhi Yan, Yan Li, J. Bao (2010)
Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin.Phytomedicine : international journal of phytotherapy and phytopharmacology, 18 1
S. Meloche, J. Pouysségur (2007)
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transitionOncogene, 26
Leonardus Koharudin, A. Gronenborn (2011)
Structural basis of the anti-HIV activity of the cyanobacterial Oscillatoria Agardhii agglutinin.Structure, 19 8
E. Damme, A. Allen, W. Peumans (1987)
Isolation and characterization of a lectin with exclusive specificity towards mannose from snowdrop (Galanthus nivalis) bulbsFEBS Letters, 215
H. Saïdi, Nadine Nasreddine, Mohammad-Ali Jenabian, M. Lecerf, D. Schols, C. Krief, J. Balzarini, L. Bélec (2007)
Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins : Implication for microbicide developmentJournal of Translational Medicine, 5
T. Geijtenbeek, D. Kwon, R. Torensma, S. Vliet, G. Duijnhoven, J. Middel, I. Cornelissen, H. Nottet, V. KewalRamani, D. Littman, C. Figdor, Y. Kooyk (2000)
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T CellsCell, 100
(2008)
Adv. Bot. Res
L. Wright, E. Damme, A. Barre, Anthony Allen, F. Leuven, Colin Reynolds, Pierre Rougé, W. Peumans (1999)
Isolation, characterization, molecular cloning and molecular modelling of two lectins of different specificities from bluebell (Scilla campanulata) bulbs.The Biochemical journal, 340 ( Pt 1)
Anita Gupta, R. Sandhu (2004)
A new high molecular weight agglutinin from garlic (Allium sativum)Molecular and Cellular Biochemistry, 166
Shu-ya Wang, Qi-jia Yu, J. Bao, Bo Liu (2011)
Polygonatum cyrtonema lectin, a potential antineoplastic drug targeting programmed cell death pathways.Biochemical and biophysical research communications, 406 4
Gianni Vandenborre, G. Smagghe, E. Damme (2011)
Plant lectins as defense proteins against phytophagous insects.Phytochemistry, 72 13
M. Colmenares, A. Puig‐Kröger, O. Pello, Á. Corbí, L. Rivas (2002)
Dendritic Cell (DC)-specific Intercellular Adhesion Molecule 3 (ICAM-3)-grabbing Nonintegrin (DC-SIGN, CD209), a C-type Surface Lectin in Human DCs, Is a Receptor for LeishmaniaAmastigotes*The Journal of Biological Chemistry, 277
Bo Liu, Bo Zhang, Mingwei Min, H. Bian, Longfei Chen, Qian Liu, J. Bao (2009)
Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells.Biochimica et biophysica acta, 1790 8
Bo Liu, Yan Cheng, Qian Liu, J. Bao, Jin-Ming Yang (2010)
Autophagic pathways as new targets for cancer drug development, 31
J. Balzarini (2006)
Inhibition of HIV entry by carbohydrate-binding proteins.Antiviral research, 71 2-3
Leonardus Koharudin, W. Furey, A. Gronenborn (2010)
Novel Fold and Carbohydrate Specificity of the Potent Anti-HIV Cyanobacterial Lectin from Oscillatoria agardhii*The Journal of Biological Chemistry, 286
(2005)
J. Biol. Chem
(2001)
Multivalent proteincarbohydrate interactions
K. Smeets, Els Damme, F. Leuven, W. Peumans (1997)
Isolation, characterization and molecular cloning of a leaf-specific lectin from ramsons (Allium ursinum L.).Plant Molecular Biology, 35
J. Balzarini, K. Laethem, W. Peumans, E. Damme, A. Bolmstedt, F. Gago, D. Schols (2006)
Mutational Pathways, Resistance Profile, and Side Effects of Cyanovirin Relative to Human Immunodeficiency Virus Type 1 Strains with N-Glycan Deletions in Their gp120 EnvelopesJournal of Virology, 80
N. Shibuya, I. Goldstein, E. Damme, W. Peumans (1988)
Binding properties of a mannose-specific lectin from the snowdrop (Galanthus nivalis) bulb.The Journal of biological chemistry, 263 2
Galanthus nivalis agglutinin (GNA)-related lectin family, a superfamily of strictly mannose-binding specific lectins widespread among monocotyledonous plants, is well-known to possess a broad range of biological functions such as anti-tumor, anti-viral and anti-fungal activities. Herein, we mainly focused on exploring the precise molecular mechanisms by which GNA-related lectins induce cancer cell apoptotic and autophagic death targeting mitochondria-mediated ROS-p38-p53 apoptotic or autophagic pathway, Ras-Raf and PI3K-Akt anti-apoptotic or anti-autophagic pathways. In addition, we further discussed the molecular mechanisms of GNA-related lectins exerting anti-viral activities by blocking the entry of the virus into its target cells, preventing transmission of the virus as well as forcing virus to delete glycan in its envelope protein and triggering neutralizing antibody. In conclusion, these findings may provide a new perspective of GNA-related lectins as potential drugs for cancer and virus therapeutics in the future.
Glycoconjugate Journal – Springer Journals
Published: Aug 15, 2012
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