Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies

Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool and therapeutic. The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, enables the development of more controllable and precise CRISPR-Cas tools. Here we discuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystems. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Methods Springer Journals

Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies

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Publisher
Springer Journals
Copyright
Copyright © Springer Nature America, Inc. 2020
ISSN
1548-7091
eISSN
1548-7105
DOI
10.1038/s41592-020-0771-6
Publisher site
See Article on Publisher Site

Abstract

Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool and therapeutic. The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, enables the development of more controllable and precise CRISPR-Cas tools. Here we discuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystems.

Journal

Nature MethodsSpringer Journals

Published: May 16, 2020

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