Access the full text.
Sign up today, get DeepDyve free for 14 days.
A Mazzocca, E Fransvea, F Dituri, L Lupo, S Antonaci, G Giannelli (2010)
Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinomaHepatology, 51
(1995)
Terminology of nodular hepatocellular lesionsHepatology, 22
AG Renehan, M Harvie, A Howell (2006)
Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years onEndocr. Relat. Canc., 13
M Kamal, AM Shaaban, L Zhang, C Walker, S Gray, N Thakker, C Toomes, V Speirs, SM Bell (2010)
Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinomaBreast Canc. Res. Treat., 121
JI Pérez-Carreón, C López-García, S Fattel-Fazenda, E Arce-Popoca, L Alemán-Lazarini, S Hernández-García, V Berre, S Sokol, JM Francois, S Villa-Treviño (2006)
Gene expression profile related to the progression of preneoplastic nodules toward hepatocellular carcinoma in ratsNeoplasia, 8
N Zhu, Y Shao, L Xu, L Yu, L Sun (2009)
Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cellsMol. Biol. Rep., 36
AC Blackburn, LZ Hill, AL Roberts, J Wang, D Aud, J Jung, T Nikolcheva, J Allard, G Peltz, CN Otis, QJ Cao, RS Ricketts, SP Naber, J Mollenhauer, A Poustka, D Malamud, DJ Jerry (2007)
Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer riskAm. J. Pathol., 170
JM Llovet, Y Chen, E Wurmbach, S Roayaie, MI Fiel, M Schwartz, SN Thung, G Khitrov, W Zhang, A Villanueva, C Battiston, V Mazzaferro, J Bruix, S Waxman, SL Friedman (2006)
A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosisGastroenterology, 131
CM Shachaf, AM Kopelman, C Arvanitis, A Karlsson, S Beer, S Mandl, MH Bachman, AD Borowsky, B Ruebner, RD Cardiff, Q Yang, JM Bishop, CH Contag, DW Felsher (2004)
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancerNature, 431
DF Calvisi, MM Simile, S Ladu, R Pellegrino, V Murtas, F Pinna, ML Tomasi, M Frau, P Virdis, MR Miglio, MR Muroni, RM Pascale, F Feo (2007)
Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosisInt. J. Cancer, 121
Y Hoshida, A Villanueva, M Kobayashi, J Peix, DY Chiang, A Camargo, S Gupta, J Moore, MJ Wrobel, J Lerner, M Reich, JA Chan, JN Glickman, K Ikeda, M Hashimoto, G Watanabe, MG Daidone, S Roayaie, M Schwartz, S Thung, HB Salvesen, S Gabriel, V Mazzaferro, J Bruix, SL Friedman, H Kumada, JM Llovet, TR Golub (2008)
Gene expression in fixed tissues and outcome in hepatocellular carcinomaN. Engl. J. Med., 359
DF Calvisi, F Pinna, F Meloni, S Ladu, R Pellegrino, M Sini, L Daino, MM Simile, MR Miglio, P Virdis, M Frau, ML Tomasi, MA Seddaiu, MR Muroni, F Feo, RM Pascale (2008)
Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinomaCancer Res., 68
M Frau, S Ladu, DF Calvisi, MM Simile, P Bonelli, L Daino, ML Tomasi, MA Seddaiu, F Feo, RM Pascale (2011)
Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotypeJ. Hepatol., 55
JB Andersen, R Loi, A Perra, GM Ledda-Columbano, A Columbano, SS Thorgeirsson (2010)
Progenitor-derived hepatocellular carcinoma model in the ratHepatology, 51
A Villanueva, P Newell, DY Chiang, SL Friedman, JM Llovet (2007)
Genomics and signaling pathways in hepatocellular carcinomaSemin. Liver Dis., 27
JS Lee, IS Chu, A Mikaelyan, DF Calvisi, J Heo, JK Reddy, SS Thorgeirsson (2004)
Application of comparative functional genomics to identify best-fit mouse models to study human cancerNat. Genet., 36
V Factor, AL Oliver, GR Panta, SS Thorgeirsson, GE Sonenshein, M Arsura (2001)
Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic miceHepatology, 34
F Feo, MR Miglio, MM Simile, MR Muroni, DF Calvisi, M Frau (2006)
Hepatocellular carcinoma as a complex polygenic disease. Interpretative analysis of recent developments on genetic predispositionBiochim. Biophys. Acta Canc. Rev., 1765
PJ Eichhorn, MP Creyghton, R Bernards (2009)
Protein phosphatase 2A regulatory subunits and cancerBiochim. Biophys. Acta, 179
JS Lee, IS Chu, J Heo, DF Calvisi, Z Sun, T Roskams, A Durnez, AJ Demetris, SS Thorgeirsson (2004)
Classification and prediction of survival in hepatocellular carcinoma by gene expression profilingHepatology, 40
A Sweet-Cordero, S Mukherjee, A Subramanian, H You, JJ Roix, C Ladd-Acosta, J Mesirov, TR Golub, T Jacks (2005)
An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysisNat. Genet., 37
T Ueno, G Elmberger, TE Weaver, M Toi, S Linder (2008)
The aspartic protease napsin A suppresses tumor growth independent of its catalytic activityLab. Investig., 88
JM Llovet, J Bruix (2008)
Novel advancements in the management of hepatocellular carcinoma in 2008J. Hepatol., 48
J Mollenhauer, B Helmke, D Medina, G Bergmann, N Gassler, H Müller, S Lyer, L Diedrichs, M Renner, R Wittig, S Blaich, U Hamann, J Madsen, U Holmskov, F Bikker, A Ligtenberg, A Carlén, J Olsson, HF Otto, B O’Malley, A Poustka (2004)
Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesisGenes Chrom. Cancer, 39
OM Andrisani, L Studach, P Merle (2011)
Gene signatures in hepatocellular carcinoma (HCC)Semin. Cancer Biol., 21
J Du, M Guan, J Fan, H Jiang (2011)
Loss of DMBT1 expression in human prostate cancer and its correlation with clinical progressive featuresUrology, 77
P Kaposi-Novak, L Libbrecht, HG Woo, YH Lee, NC Sears, C Coulouarn, EA Conner, VM Factor, T Roskams, SS Thorgeirsson (2009)
Central role of c-Myc during malignant conversion in human hepatocarcinogenesisCancer Res., 69
SC Lu, JM Mato (2008)
S-Adenosylmethionine in cell growth, apoptosis and liver cancerJ. Gastroenterol. Hepatol., 23
SH Yeh, DC Wu, CY Tsai, TJ Kuo, WC Yu, YS Chang, CL Chen, CF Chang, DS Chen, PJ Chen (2006)
Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinomaClin. Cancer Res., 12
P Parekh, KV Rao (2007)
Overexpression of cyclin D1 is associated with elevated levels of MAP kinases, Akt and Pak1 during diethylnitrosamine-induced progressive liver carcinogenesisCell Biol. Int., 31
RM Pascale, MM Simile, DF Calvisi, M Frau, MR Muroni, MA Seddaiu, L Daino, MD Muntoni, MR Miglio, SS Thorgeirsson, F Feo (2005)
Role of the modulation of p16INK4A and E2f4 activity by Cdc37, Hsp90 and Crm1 in the phenotypic behavior of preneoplastic and neoplastic liver lesions of rat strains with different genetic predisposition to hepatocarcinogenesis and in human liver cancerHepatology, 42
DF Calvisi, MM Simile, S Ladu, M Frau, M Evert, ML Tomasi, MI Demartis, L Daino, MA Seddaiu, S Brozzetti, F Feo, RM Pascale (2011)
Activation of MYBL2-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of HCC with mutant p53Hepatology, 53
M Bittner, P Meltzer, Y Chen, Y Jiang, E Seftor, M Hendrix, M Radmacher, R Simon, Z Yakhini, A Ben-Dor, N Sampas, E Dougherty, E Wang, F Marincola, C Gooden, J Lueders, A Glatfelter, P Pollock, J Carpten, E Gillanders, D Leja, K Dietrich, C Beaudry, M Berens, D Alberts, V Sondak (2000)
Molecular classification of cutaneous malignant melanoma by gene expression profilingNature, 406
MM Simile, MR Miglio, MR Muroni, S Pusceddu, D Calvisi, A Carru, MA Seddaiu, L Daino, L Deiana, RM Pascale, F Feo (2004)
Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cellsCarcinogenesis, 25
SW Nam, JY Park, A Ramasamy, S Shevade, A Islam, PM Long, CK Park, SE Park, SY Kim, SH Lee, WS Park, NJ Yoo, ET Liu, LD Miller, JY Lee (2005)
Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profilingHepatology, 42
P Bioulac-Sage, S Rebouissou, C Thomas, JF Blanc, J Saric, A Sa Cunha, A Rullier, G Cubel, G Couchy, S Imbeaud, C Balabaud, J Zucman-Rossi (2007)
Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistryHepatology, 46
K Ellwood-Yen, TG Graeber, J Wongvipat, ML Iruela-Arispe, J Zhang, R Matusik, GV Thomas, CL Sawyers (2003)
Myc-driven murine prostate cancer shares molecular features with human prostate tumorsCancer Cell, 4
MA Avila, C Berasain, L Torres, A Martín-Duce, FJ Corrales, H Yang, J Prieto, SC Lu, J Caballería, J Rodés, JM Mato (2000)
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinomaJ. Hepatol., 33
M Sakamoto (2009)
Early HCC: diagnosis and molecular markersJ. Gastroenterol., 44
TL Tseng, YP Shih, YC Huang, CK Wang, PH Chen, JG Chang, KT Yeh, YM Chen, KH Buetow (2003)
Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancerCancer Res., 63
RA Squire, MH Levitt (1975)
Report of a workshop on classification of specific hepatocellular lesions in ratsCancer Res., 35
JS Lee, J Heo, L Libbrecht, IS Chu, P Kaposi-Novak, DF Calvisi, A Mikaelyan, LR Roberts, AJ Demetris, Z Sun, F Nevens, T Roskams, SS Thorgeirsson (2006)
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cellsNat. Med., 12
P Kaposi-Novak, JS Lee, L Gòmez-Quiroz, C Coulouarn, VM Factor, SS Thorgeirsson (2006)
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotypeJ. Clin. Invest., 116
M Frau, F Biasi, F Feo, RM Pascale (2010)
Prognostic markers and putative therapeutic targets for hepatocellular carcinomaMol. Aspects Med., 31
JS Lee, SS Thorgeirsson (2006)
Comparative and integrative functional genomics of HCCOncogene, 25
M Sasaki, SF Huang, MF Chen, YY Jan, TS Yeh, A Ishikawa, J Mollenhauer, A Poustka, K Tsuneyama, Y Nimura, K Oda, Y Nakanuma (2003)
Decrease of deleted in malignant brain tumour-1 (DMBT-1) expression is a crucial late event in intrahepatic cholangiocarcinomaHistopathology, 43
DF Calvisi, S Ladu, F Pinna, M Frau, ML Tomasi, M Sini, MM Simile, P Bonelli, MR Muroni, MA Seddaiu, DS Lim, F Feo, RM Pascale (2009)
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosisGastroenterology, 137
DB Solt, A Medline, E Farber (1997)
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesisAm. J. Pathol., 88
Our results disclose, for the first time, a major role of oncosuppressor genes as effectors of genetic resistance to hepatocarcinogenesis. Comparative functional genomic analysis allowed discovering an evolutionarily conserved gene expression signature discriminating HCC with different propensity to progression in rat and human.
Cellular Oncology – Springer Journals
Published: Mar 21, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.