CNS Drugs https://doi.org/10.1007/s40263-018-0515-7 OR IGINAL RESEARCH ARTIC L E Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer’s Disease 1 1 1,2,3 • ´ • ´ • Patricia del Cerro Carolina Alquezar Fernando Bartolome 4 4 2,3 4 • • • • Pedro Gonza ´ lez-Naranjo Concepcio ´nPe ´rez Eva Carro Juan A. Pa ´ ez 5 1,6 Nuria E. Campillo Angeles Mart´ ın-Requero Springer International Publishing AG, part of Springer Nature 2018 Abstract Methods Lymphoblastoid cell lines from patients with Alz- Background Alzheimer’s disease is a multifactorial disor- heimer’s disease and age-matched control individuals were der for which there is no disease-modifying treatment yet. treated with a new, in-house-designed dual drug PGN33, CB2 receptors have emerged as a promising therapeutic which behaves as a CB2 agonist and butyrylcholinesterase target for Alzheimer’s disease because they are expressed inhibitor. We analyzed the effects of this compound on the rate in neuronal and glial cells and their activation has no of cell proliferation and levels of key regulatory proteins. In psychoactive effects. addition, we investigated the potential neuroprotective action Objective The aim of this study was to
CNS Drugs – Springer Journals
Published: May 7, 2018
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