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Action of phenothiazine derivatives on carbohydrate uptake of isolated rat diaphragm and isolated rat spinal cord

Action of phenothiazine derivatives on carbohydrate uptake of isolated rat diaphragm and isolated... 213 2 2 3 3 Ole J. Rafaelsen Department of Psychiatry University of Aarhus Denmark Summary 1. Chlorpromazine in vitro reduces the glucose uptake of isolated rat diaphragm and isolated rat spinal cord by 25%. Minimum effective dose of chlorpromazine was 0.25 mg./100 ml. in rat diaphragm experiments and 2.5 mg./100 ml. in rat spinal cord experiments. Perphenazine and prochlorperazine were also effective, whereas a series of other drugs — phenothiazine derivatives and others — were without effect on the glucose uptake of the two tissue samples used. Imipramine in high concentrations reduced the glucose uptake of rat diaphragm, but not that of rat spinal cord. 2. Chlorpromazine also reduced the uptake of d -fructose and d -galactose, but not of d -arabinose, in the isolated rat diaphragm. 3. When both chlorpromazine and insulin were present in the medium in rat diaphragm and in rat spinal cord experiments, the glucose uptake was dependent on the insulin concentration. Insulin in sufficient doses obviated the effect of chlorpromazine, but even in high doses did not exert the same quantitative effect on the glucose uptake in the presence of chlorpromazine as in the absence of this drug. 4. The results obtained are consistent with the assumption that chlorpromazine and other chlorphenothiazine derivatives influence the insulin sensitive glucose transport system in cell membranes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Action of phenothiazine derivatives on carbohydrate uptake of isolated rat diaphragm and isolated rat spinal cord

Rafaelsen, Ole
Psychopharmacology , Volume 2 (3) – May 1, 1961
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References (24)

Publisher
Springer Journals
Copyright
Copyright © 1961 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00407978
Publisher site
See Article on Publisher Site

Abstract

213 2 2 3 3 Ole J. Rafaelsen Department of Psychiatry University of Aarhus Denmark Summary 1. Chlorpromazine in vitro reduces the glucose uptake of isolated rat diaphragm and isolated rat spinal cord by 25%. Minimum effective dose of chlorpromazine was 0.25 mg./100 ml. in rat diaphragm experiments and 2.5 mg./100 ml. in rat spinal cord experiments. Perphenazine and prochlorperazine were also effective, whereas a series of other drugs — phenothiazine derivatives and others — were without effect on the glucose uptake of the two tissue samples used. Imipramine in high concentrations reduced the glucose uptake of rat diaphragm, but not that of rat spinal cord. 2. Chlorpromazine also reduced the uptake of d -fructose and d -galactose, but not of d -arabinose, in the isolated rat diaphragm. 3. When both chlorpromazine and insulin were present in the medium in rat diaphragm and in rat spinal cord experiments, the glucose uptake was dependent on the insulin concentration. Insulin in sufficient doses obviated the effect of chlorpromazine, but even in high doses did not exert the same quantitative effect on the glucose uptake in the presence of chlorpromazine as in the absence of this drug. 4. The results obtained are consistent with the assumption that chlorpromazine and other chlorphenothiazine derivatives influence the insulin sensitive glucose transport system in cell membranes.

Journal

Psychopharmacology – Springer Journals

Published: May 1, 1961

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