A tooth-binding antimicrobial peptide to prevent the formation of dental biofilm

A tooth-binding antimicrobial peptide to prevent the formation of dental biofilm Dental caries is primarily caused by pathogenic bacteria infection, and Streptococcus mutans is considered a major cariogenic pathogen. A tooth-binding antimicrobial peptide was designed by grafted diphosphoserine (-Ser(p)-Ser(p)-) to the structure of polyphemusin I. This novel tooth-binding antimicrobial peptide can inhibit dental plaque biofilm development and thus provide a feasible alternative to conventional antibiotics for the prevention and treatment of dental caries. * Chris Ying Cao Key Laboratory of Oral Diseases Research of Anhui Province, caoying0713@gmail.com College and Hospital of Stomatology, Anhui Medical University, 230032 Hefei, China 1234567890();,: 1234567890();,: 45 Page 2 of 9 Journal of Materials Science: Materials in Medicine (2019) 30:45 1 Introduction remain in their clinical application. Such challenges include the high cost of production, the identical effective Dental caries is the most prevalent oral disease and con- concentration of AMPs against saliva dilution and sidered a major public health problem [1]. Studies have degradation [18]. To circumvent these problems, scholars indicated that caries is caused by many cariogenic microbes, have developed synthetic analogs or fragments of natural among which Streptococcus mutans is regarded a major AMPs that show promising antibacterial activity [19]. pathogen because of this microbe’s acidogenic and aciduric Synthetic peptides are created by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Materials Science: Materials in Medicine Springer Journals

A tooth-binding antimicrobial peptide to prevent the formation of dental biofilm

Loading next page...
 
/lp/springer-journals/a-tooth-binding-antimicrobial-peptide-to-prevent-the-formation-of-FDch0CYuY1
Publisher
Springer Journals
Copyright
Copyright © 2019 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Materials Science; Biomaterials; Biomedical Engineering and Bioengineering; Regenerative Medicine/Tissue Engineering; Polymer Sciences; Ceramics, Glass, Composites, Natural Materials; Surfaces and Interfaces, Thin Films
ISSN
0957-4530
eISSN
1573-4838
D.O.I.
10.1007/s10856-019-6246-6
Publisher site
See Article on Publisher Site

Abstract

Dental caries is primarily caused by pathogenic bacteria infection, and Streptococcus mutans is considered a major cariogenic pathogen. A tooth-binding antimicrobial peptide was designed by grafted diphosphoserine (-Ser(p)-Ser(p)-) to the structure of polyphemusin I. This novel tooth-binding antimicrobial peptide can inhibit dental plaque biofilm development and thus provide a feasible alternative to conventional antibiotics for the prevention and treatment of dental caries. * Chris Ying Cao Key Laboratory of Oral Diseases Research of Anhui Province, caoying0713@gmail.com College and Hospital of Stomatology, Anhui Medical University, 230032 Hefei, China 1234567890();,: 1234567890();,: 45 Page 2 of 9 Journal of Materials Science: Materials in Medicine (2019) 30:45 1 Introduction remain in their clinical application. Such challenges include the high cost of production, the identical effective Dental caries is the most prevalent oral disease and con- concentration of AMPs against saliva dilution and sidered a major public health problem [1]. Studies have degradation [18]. To circumvent these problems, scholars indicated that caries is caused by many cariogenic microbes, have developed synthetic analogs or fragments of natural among which Streptococcus mutans is regarded a major AMPs that show promising antibacterial activity [19]. pathogen because of this microbe’s acidogenic and aciduric Synthetic peptides are created by

Journal

Journal of Materials Science: Materials in MedicineSpringer Journals

Published: Mar 30, 2019

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off