Dental caries is primarily caused by pathogenic bacteria infection, and Streptococcus mutans is considered a major cariogenic pathogen. A tooth-binding antimicrobial peptide was designed by grafted diphosphoserine (-Ser(p)-Ser(p)-) to the structure of polyphemusin I. This novel tooth-binding antimicrobial peptide can inhibit dental plaque bioﬁlm development and thus provide a feasible alternative to conventional antibiotics for the prevention and treatment of dental caries. * Chris Ying Cao Key Laboratory of Oral Diseases Research of Anhui Province, firstname.lastname@example.org College and Hospital of Stomatology, Anhui Medical University, 230032 Hefei, China 1234567890();,: 1234567890();,: 45 Page 2 of 9 Journal of Materials Science: Materials in Medicine (2019) 30:45 1 Introduction remain in their clinical application. Such challenges include the high cost of production, the identical effective Dental caries is the most prevalent oral disease and con- concentration of AMPs against saliva dilution and sidered a major public health problem . Studies have degradation . To circumvent these problems, scholars indicated that caries is caused by many cariogenic microbes, have developed synthetic analogs or fragments of natural among which Streptococcus mutans is regarded a major AMPs that show promising antibacterial activity . pathogen because of this microbe’s acidogenic and aciduric Synthetic peptides are created by
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Mar 30, 2019
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