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A Systems Biology Approach to BloodSystems Biology of Platelet–Vessel Wall Interactions

A Systems Biology Approach to Blood: Systems Biology of Platelet–Vessel Wall Interactions [Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel’s breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction. Development of multi-scale models coupling processes at several scales and running predictive model simulations on powerful computer clusters can help interdisciplinary groups of researchers to suggest and test new patient-specific treatment strategies.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Systems Biology Approach to BloodSystems Biology of Platelet–Vessel Wall Interactions

Part of the Advances in Experimental Medicine and Biology Book Series (volume 844)
Editors: Corey, Seth Joel; Kimmel, Marek; Leonard, Joshua N.
Chen, Yolande; Corey, Seth Joel; Kim, Oleg V.; Alber, Mark S.
A Systems Biology Approach to Blood — Dec 6, 2014
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Publisher
Springer New York
Copyright
© Springer Science+Business Media New York 2014
ISBN
978-1-4939-2094-5
Pages
85 –98
DOI
10.1007/978-1-4939-2095-2_5
Publisher site
See Chapter on Publisher Site

Abstract

[Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel’s breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction. Development of multi-scale models coupling processes at several scales and running predictive model simulations on powerful computer clusters can help interdisciplinary groups of researchers to suggest and test new patient-specific treatment strategies.]

Published: Dec 6, 2014

Keywords: Platelets; Blood vessels; Hemostasis; Thrombosis

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