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A Short History of the Drug Receptor ConceptThe Dual Adrenalin Receptor Theory of Raymond P. Ahlquist (1914–83) and its Application in Drug Development between 1950 and 1970

A Short History of the Drug Receptor Concept: The Dual Adrenalin Receptor Theory of Raymond P.... [In the previous chapters we have seen that the early introduction of the receptor concept by Langley and Ehrlich was a very hypothetical approach and was considered only as one of a number of options available to clarify the problem of drug binding. Consequently, its fate remained uncertain within the scientific community of pharmacologists during the first half of the twentieth century. The most important representatives of the discipline propagated competing alternative theories as well as alternative research strands. In spite of this, the receptor concept survived, particularly through the development of quantitative theories of drug action, which achieved a clear breakthrough in the 1930s with Alfred Joseph Clark’s work on drug binding to cells. After Clark’s early death, scientists such as Gaddum, Ariëns and Stephenson deepened the research on the mechanism of drug binding to receptors (see Chapter 5).] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

A Short History of the Drug Receptor ConceptThe Dual Adrenalin Receptor Theory of Raymond P. Ahlquist (1914–83) and its Application in Drug Development between 1950 and 1970

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Publisher
Palgrave Macmillan UK
Copyright
© Palgrave Macmillan, a division of Macmillan Publishers Limited 2009
ISBN
978-1-349-36377-3
Pages
125 –145
DOI
10.1057/9780230583740_7
Publisher site
See Chapter on Publisher Site

Abstract

[In the previous chapters we have seen that the early introduction of the receptor concept by Langley and Ehrlich was a very hypothetical approach and was considered only as one of a number of options available to clarify the problem of drug binding. Consequently, its fate remained uncertain within the scientific community of pharmacologists during the first half of the twentieth century. The most important representatives of the discipline propagated competing alternative theories as well as alternative research strands. In spite of this, the receptor concept survived, particularly through the development of quantitative theories of drug action, which achieved a clear breakthrough in the 1930s with Alfred Joseph Clark’s work on drug binding to cells. After Clark’s early death, scientists such as Gaddum, Ariëns and Stephenson deepened the research on the mechanism of drug binding to receptors (see Chapter 5).]

Published: Sep 25, 2015

Keywords: Adrenergic Receptor; Nobel Prize; Short History; Drug Binding; Nictitate Membrane

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