A role played by sigma receptors in the conditioned suppression of motility in mice

A role played by sigma receptors in the conditioned suppression of motility in mice 213 94 94 4 4 Toshitaka Nabeshima Hiroyuki Kamei Tsutomu Kameyama Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences Meijo University 468 Nagoya Japan Abstract Mice exhibited marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric foot-shock. The conditioned suppression was attenuated by cyclazocine and N-allylnormetazocine (SKF-10047), sigma agonists. The effect of these drugs was reduced by chronic pretreatment with cyclazocine. This behavioral change was related to the change in binding activity of ( 3 H)-phencyclidine to sigma receptors (defined using non-radioactive SKF-10047). In the chronic vehicle-pretreated conditioned suppression group, the K d and B max values of ( 3 H)-phencyclidine binding at the high affinity site were increased when compared to those in the chronic vehicle-pretreated control group. The increased values were restored to the control levels by acute treatment with cyclazocine and SKF-10047. On the other hand, in the chronic cyclazocine-pretreated conditioned suppression group, acute cyclazocine and SKF-10047 treatment failed to change the increased values of K d and B max at the high affinity site. The present behavioral and receptor-binding experiments suggest that the activation of nervous system mediated by sigma receptors may be responsible for the attenuation of conditioned suppression of motility. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

A role played by sigma receptors in the conditioned suppression of motility in mice

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Publisher
Springer Journals
Copyright
Copyright © 1988 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00212847
Publisher site
See Article on Publisher Site

Abstract

213 94 94 4 4 Toshitaka Nabeshima Hiroyuki Kamei Tsutomu Kameyama Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences Meijo University 468 Nagoya Japan Abstract Mice exhibited marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric foot-shock. The conditioned suppression was attenuated by cyclazocine and N-allylnormetazocine (SKF-10047), sigma agonists. The effect of these drugs was reduced by chronic pretreatment with cyclazocine. This behavioral change was related to the change in binding activity of ( 3 H)-phencyclidine to sigma receptors (defined using non-radioactive SKF-10047). In the chronic vehicle-pretreated conditioned suppression group, the K d and B max values of ( 3 H)-phencyclidine binding at the high affinity site were increased when compared to those in the chronic vehicle-pretreated control group. The increased values were restored to the control levels by acute treatment with cyclazocine and SKF-10047. On the other hand, in the chronic cyclazocine-pretreated conditioned suppression group, acute cyclazocine and SKF-10047 treatment failed to change the increased values of K d and B max at the high affinity site. The present behavioral and receptor-binding experiments suggest that the activation of nervous system mediated by sigma receptors may be responsible for the attenuation of conditioned suppression of motility.

Journal

PsychopharmacologySpringer Journals

Published: Apr 1, 1988

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