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A Review of Genome Wide Association Studies for Erectile Dysfunction

A Review of Genome Wide Association Studies for Erectile Dysfunction Purpose of Review To review large cohort genome wide association studies for erectile dysfunction. Recent Findings Two recent genome wide association studies using the Genetic Epidemiology Research in Adult Health and Aging cohort, UK Biobank, and the Partners HealthCare Biobank have identified an association between unique single nucle- otide polymorphisms involved in the regulatory activity of single-minded homolog 1 (SIM1) and risk of erectile dysfunction. SIM1 is involved in the leptin-melanocortin pathway and may contribute to centrally mediated erectile dysfunction. Summary Identification of novel loci associated with erectile function from genome wide association studies will help expand the understanding of the breadth of pathways that contribute to erectile dysfunction. This will help accelerate studies of novel therapies for the treatment of erectile dysfunction. . . . . Keywords Erectile dysfunction Sexual dysfunction, physiological Genome-wide association study Genetic therapy SIM1 protein, human Introduction an erection when adjusted for various ED risk factors. This was one of the first studies to support a genetic component to Erectile dysfunction (ED) is the inability to get or maintain a ED. penile erection and is one of the most common medical con- A number of candidate gene studies have linked gene poly- ditions in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Sexual Health Reports Springer Journals

A Review of Genome Wide Association Studies for Erectile Dysfunction

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References (35)

Publisher
Springer Journals
Copyright
Copyright © 2019 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Urology; Endocrinology
ISSN
1548-3584
eISSN
1548-3592
DOI
10.1007/s11930-019-00231-w
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review To review large cohort genome wide association studies for erectile dysfunction. Recent Findings Two recent genome wide association studies using the Genetic Epidemiology Research in Adult Health and Aging cohort, UK Biobank, and the Partners HealthCare Biobank have identified an association between unique single nucle- otide polymorphisms involved in the regulatory activity of single-minded homolog 1 (SIM1) and risk of erectile dysfunction. SIM1 is involved in the leptin-melanocortin pathway and may contribute to centrally mediated erectile dysfunction. Summary Identification of novel loci associated with erectile function from genome wide association studies will help expand the understanding of the breadth of pathways that contribute to erectile dysfunction. This will help accelerate studies of novel therapies for the treatment of erectile dysfunction. . . . . Keywords Erectile dysfunction Sexual dysfunction, physiological Genome-wide association study Genetic therapy SIM1 protein, human Introduction an erection when adjusted for various ED risk factors. This was one of the first studies to support a genetic component to Erectile dysfunction (ED) is the inability to get or maintain a ED. penile erection and is one of the most common medical con- A number of candidate gene studies have linked gene poly- ditions in

Journal

Current Sexual Health Reports – Springer Journals

Published: Nov 6, 2019

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