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A Five-Year Prospective Study of the Health of Children in Different Ethnic Groups, with Particular Reference to the Effect of Inbreeding

A Five-Year Prospective Study of the Health of Children in Different Ethnic Groups, with... A 5-year prospective study of 4,934 children of different ethnic groups has demonstrated a 3-fold increase of postneonatal mortality and childhood morbidity in the offspring of consanguineous Pakistani parents. Most of these families contained more than one consanguineous union, resulting in a mean inbreeding coefficient for their children of 0.0686. It is estimated that 60% of the mortality and severe morbidity of this group of children could be eliminated if inbreeding ceased. However consanguinity is much favoured in this minority group, and health education will have to be carefully and sensitively handled. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Human Genetics Springer Journals

A Five-Year Prospective Study of the Health of Children in Different Ethnic Groups, with Particular Reference to the Effect of Inbreeding

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References (26)

Publisher
Springer Journals
Copyright
Copyright © 1993 by S. Karger AG, Basel
Subject
Biomedicine; Biomedicine, general; Human Genetics; Bioinformatics; Gene Expression; Cytogenetics
ISSN
1018-4813
eISSN
1476-5438
DOI
10.1159/000472414
Publisher site
See Article on Publisher Site

Abstract

A 5-year prospective study of 4,934 children of different ethnic groups has demonstrated a 3-fold increase of postneonatal mortality and childhood morbidity in the offspring of consanguineous Pakistani parents. Most of these families contained more than one consanguineous union, resulting in a mean inbreeding coefficient for their children of 0.0686. It is estimated that 60% of the mortality and severe morbidity of this group of children could be eliminated if inbreeding ceased. However consanguinity is much favoured in this minority group, and health education will have to be carefully and sensitively handled.

Journal

European Journal of Human GeneticsSpringer Journals

Published: Mar 5, 1993

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