A conserved trans -regulatory landscape for scute expression on the notum of cyclorraphous Diptera

A conserved trans -regulatory landscape for scute expression on the notum of cyclorraphous Diptera Bristles on the notum of many cyclorraphous flies are arranged into species-specific stereotyped patterns. The positions of bristles correlate with differences in the spatial expression of the scute (sc) gene in those species examined so far. However, a major upstream activator of scute , Pannier (Pnr), is expressed in a conserved domain over the entire medial notum. Here we examine the expression patterns in Calliphora vicina of stripe ( sr ), u-shaped ( ush ), caupolican ( caup ) and wingless ( wg ), genes known to modify the activity of Pnr or to act downstream of Pnr in Drosophila . We find that, with minor differences, their expression patterns are conserved. This suggests that the function of a trans -regulatory network of genes is relatively unchanged in derived Diptera and that many differences are likely to be due to changes in cis -regulatory sequences of scute . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Development Genes and Evolution Springer Journals

A conserved trans -regulatory landscape for scute expression on the notum of cyclorraphous Diptera

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Publisher
Springer Journals
Copyright
Copyright © 2006 by Springer-Verlag
Subject
Life Sciences; Animal Genetics and Genomics; Biochemistry, general; Cell Biology; Neurosciences ; Developmental Biology
ISSN
0949-944X
eISSN
1432-041X
D.O.I.
10.1007/s00427-005-0028-5
Publisher site
See Article on Publisher Site

Abstract

Bristles on the notum of many cyclorraphous flies are arranged into species-specific stereotyped patterns. The positions of bristles correlate with differences in the spatial expression of the scute (sc) gene in those species examined so far. However, a major upstream activator of scute , Pannier (Pnr), is expressed in a conserved domain over the entire medial notum. Here we examine the expression patterns in Calliphora vicina of stripe ( sr ), u-shaped ( ush ), caupolican ( caup ) and wingless ( wg ), genes known to modify the activity of Pnr or to act downstream of Pnr in Drosophila . We find that, with minor differences, their expression patterns are conserved. This suggests that the function of a trans -regulatory network of genes is relatively unchanged in derived Diptera and that many differences are likely to be due to changes in cis -regulatory sequences of scute .

Journal

Development Genes and EvolutionSpringer Journals

Published: Jan 1, 2006

References

  • How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila
    Calleja, M; Renaud, O; Usui, K; Pistillo, D; Morata, G; Simpson, P
  • Development of the indirect flight muscle attachment sites in Drosophila : role of the PS integrins and the stripe gene
    Fernandes, JJ; Celniker, SE; VijayRaghavan, K

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