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Purpose of Review The expanding utilization of limited available antifungal agents has led to a pressing need to implement interventions to ensure appropriate usage. The global emergence of resistant, difficult-to-treat invasive fungal infections among the most vulnerable patient populations is a call to action to develop a multifaceted antifungal stewardship approach. Recent Findings Candida species demonstrating multi-drug resistance, including highly resistant Candida auris, are emerging threats. Azole-resistant Aspergillus fumigatus, likely initially originating in the environment, likewise presents a treatment challenge. Routine empiric and prophylactic antifungal use, though effective, further complicates this issue, with the emergence of breakthrough mold infections. Early evidence supports success with antifungal stewardship programs. Summary Broad antifungal stewardship approaches that optimize antifungal drug usage, facilitate provider education, and monitor fungal epidemiology are crucial steps to preserve the antifungal armamentarium. Future development of novel diagnostic and treatment strategies will further facilitate management of invasive fungal infections. . . . . . Keywords Antifungal stewardship Candida Aspergillus fumigatus Antifungal resistance Azole Echinocandin Introduction among physicians, pharmacists, microbiologists, and infec- tion control programs. Herein, the evolution of antifungal re- Invasive fungal infections remain a significant cause of mor- sistance as a driver to propel antifungal stewardship practice is bidity
Current Fungal Infection Reports – Springer Journals
Published: Jan 15, 2018
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