Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/a-case-based-guide-to-clinical-endocrinology-immunoglobulin-g4-and-hqlupt5cH0
References (15)
-
S. Lytton, Katharina Ponto, M. Kanitz, N. Matheis, Leonard Kohn, G. Kahaly (2010)
A novel thyroid stimulating immunoglobulin bioassay is a functional indicator of activity and severity of Graves' orbitopathy.The Journal of clinical endocrinology and metabolism, 95 5
-
D. Mckeag, C. Lane, J. Lazarus, L. Baldeschi, K. Boboridis, A. Dickinson, A. Hullo, G. Kahaly, G. Krassas, C. Marcocci, M. Marinò, M. Mourits, M. Nardi, C. Neoh, J. Orgiazzi, P. Perros, A. Pinchera, S. Pitz, M. Prummel, M. Sartini, W. Wiersinga (2006)
Clinical features of dysthyroid optic neuropathy: a European Group on Graves’ Orbitopathy (EUGOGO) surveyBritish Journal of Ophthalmology, 91
-
K. Ponto, S. Merkesdal, G. Hommel, S. Pitz, N. Pfeiffer, G. Kahaly (2013)
Public health relevance of Graves' orbitopathy.The Journal of clinical endocrinology and metabolism, 98 1
-
AA Tooley (2019)
170Ophthalmic Plast Reconstr Surg, 35
-
Ken Takeshima, Hidefumi Inaba, Yasushi Furukawa, M. Nishi, Hiroyuki Yamaoka, Waka Miyamoto, T. Ota, Asako Doi, Hiromichi Kawashima, H. Ariyasu, H. Wakasaki, H. Furuta, Taisei Nakao, H. Sasaki, T. Akamizu (2014)
Elevated serum immunoglobulin G4 levels in patients with Graves' disease and their clinical implications.Thyroid : official journal of the American Thyroid Association, 24 4
-
K. Ponto, M. Kanitz, P. Olivo, S. Pitz, N. Pfeiffer, G. Kahaly (2011)
Clinical relevance of thyroid-stimulating immunoglobulins in graves' ophthalmopathy.Ophthalmology, 118 11
-
K. Ponto, H. Binder, T. Diana, N. Matheis, Anna Otto, S. Pitz, N. Pfeiffer, G. Kahaly (2015)
Prevalence, Phenotype, and Psychosocial Well-Being in Euthyroid/Hypothyroid Thyroid-Associated Orbitopathy.Thyroid : official journal of the American Thyroid Association, 25 8
-
E. Bozkırlı, O. Bakiner, E. Bozkirli, F. Haydardedeoğlu, S. Sizmaz, A. Torun, M. Ertorer (2015)
Serum Immunoglobulin G4 levels are elevated in patients with Graves’ ophthalmopathyClinical Endocrinology, 83
-
G. Kahaly, S. Pitz, G. Hommel, M. Dittmar (2005)
Randomized, single blind trial of intravenous versus oral steroid monotherapy in Graves' orbitopathy.The Journal of clinical endocrinology and metabolism, 90 9
-
RS Bahn (2010)
726N Engl J Med, 362
-
S Zang (2011)
876J Endocrinol Investig, 34
-
S. Zang, Katharina Ponto, G. Kahaly (2011)
Clinical review: Intravenous glucocorticoids for Graves' orbitopathy: efficacy and morbidity.The Journal of clinical endocrinology and metabolism, 96 2
-
K. Ponto, T. Diana, H. Binder, N. Matheis, Susanne Pitz, N. Pfeiffer, G. Kahaly (2015)
Thyroid-stimulating immunoglobulins indicate the onset of dysthyroid optic neuropathyJournal of Endocrinological Investigation, 38
-
T. Davies, Stig Andersen, R. Latif, Y. Nagayama, G. Barbesino, M. Brito, A. Eckstein, A. Stagnaro-Ǵreen, G. Kahaly (2020)
Graves’ diseaseNature Reviews Disease Primers, 6
-
L. Bartalena, L. Baldeschi, K. Boboridis, A. Eckstein, G. Kahaly, C. Marcocci, P. Perros, M. Salvi, W. Wiersinga (2016)
The 2016 European Thyroid Association/European Group on Graves' Orbitopathy Guidelines for the Management of Graves' OrbitopathyEuropean Thyroid Journal, 5
- Publisher
- Springer International Publishing
- Copyright
- © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
- ISBN
- 978-3-030-84366-3
- Pages
- 61 –66
- DOI
- 10.1007/978-3-030-84367-0_6
- Publisher site
- See Chapter on Publisher Site
Abstract
[An interesting and novel case report describes a rare combination of Graves’ orbitopathy (GO) and elevated serum levels of immunoglobulin G4 (IgG4) which was associated with a severe clinical phenotype with compressive symptoms and signs of optic nerve neuropathy. High serum levels of stimulatory thyrotropin receptor autoantibodies were associated with both the clinical course of thyroid eye disease and the response to specific therapy. Urgent medical treatment and subsequent surgical bony decompression of the orbit led to clinical improvement and normalization of visual acuity. Measurement of serum IgG4 is recommended in severe cases of GO and/or in cases not responding to standard immunosuppressive treatment.]
Published: Jan 4, 2022
Keywords: IgG4-related orbital disease; Graves’ orbitopathy; Orbital inflammation