5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed... Nicholas Jones +44-20-76795377 +44-20-74364276 nick@psychol.ucl.ac.uk Mark S. Duxon Sheila M. King Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK Neurology CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK Abstract Rationale and objectives. m-Chlorophenylpiperazine (mCPP) induces panic in humans and dose dependently increases unconditioned escape behaviour in a novel pre-clinical model of extreme anxiety in rats, the unstable elevated exposed plus maze (UEEPM). Numerous studies indicate that the anxiogenic effects of mCPP may be mediated by its action at the 5-HT 2C receptor. This study aimed to examine the involvement of the 5-HT 2C receptor in the unconditioned fear responses observed in the UEEPM (after an acute dose of mCPP) by pre-treatment with the selective 5-HT 2C receptor antagonist SB-242084. Methods. Male Hooded Lister rats received a single dose of SB-242084 (0.1–1.0 mg/kg IP) or vehicle 40 min pre-test followed by a single dose of mCPP (1.0 mg/kg IP) or saline 30 min before being exposed to the UEEPM for a period of 5 min. Subjects' behaviour was analysed to determine the effects of SB-242084 on mCPP-induced increases in escape behaviour. Results. mCPP alone increased animals' propensity to escape from the UEEPM despite producing marked decreases in locomotor/exploratory behaviour. SB-242084 dose dependently inhibited the increases in escape and hypolocomotor effects induced by mCPP. Conclusions. These results suggest that the escape-related behaviours exhibited by animals in the UEEPM are mediated, at least in part, by activation of the 5-HT 2C receptor subtype. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

5-HT 2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze

Psychopharmacology, Volume 164 (2) – Nov 1, 2002

Loading next page...
 
/lp/springer-journals/5-ht-2c-receptor-mediation-of-unconditioned-escape-behaviour-in-the-Bqi0jTAV7O
Publisher
Springer Journals
Copyright
Copyright © 2002 by Springer-Verlag
Subject
Legacy
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/s00213-002-1197-9
pmid
12404085
Publisher site
See Article on Publisher Site

Abstract

Nicholas Jones +44-20-76795377 +44-20-74364276 nick@psychol.ucl.ac.uk Mark S. Duxon Sheila M. King Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK Neurology CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK Abstract Rationale and objectives. m-Chlorophenylpiperazine (mCPP) induces panic in humans and dose dependently increases unconditioned escape behaviour in a novel pre-clinical model of extreme anxiety in rats, the unstable elevated exposed plus maze (UEEPM). Numerous studies indicate that the anxiogenic effects of mCPP may be mediated by its action at the 5-HT 2C receptor. This study aimed to examine the involvement of the 5-HT 2C receptor in the unconditioned fear responses observed in the UEEPM (after an acute dose of mCPP) by pre-treatment with the selective 5-HT 2C receptor antagonist SB-242084. Methods. Male Hooded Lister rats received a single dose of SB-242084 (0.1–1.0 mg/kg IP) or vehicle 40 min pre-test followed by a single dose of mCPP (1.0 mg/kg IP) or saline 30 min before being exposed to the UEEPM for a period of 5 min. Subjects' behaviour was analysed to determine the effects of SB-242084 on mCPP-induced increases in escape behaviour. Results. mCPP alone increased animals' propensity to escape from the UEEPM despite producing marked decreases in locomotor/exploratory behaviour. SB-242084 dose dependently inhibited the increases in escape and hypolocomotor effects induced by mCPP. Conclusions. These results suggest that the escape-related behaviours exhibited by animals in the UEEPM are mediated, at least in part, by activation of the 5-HT 2C receptor subtype.

Journal

PsychopharmacologySpringer Journals

Published: Nov 1, 2002

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off