The Bowel and Migraine: Update on Celiac Disease and Irritable Bowel Syndrome

The Bowel and Migraine: Update on Celiac Disease and Irritable Bowel Syndrome This article explores possible relationships between migraine, irritable bowel syndrome (IBS), celiac disease (CD), and gluten sensitivity. These seemingly distinct medical entities curiously share many common epidemiological, psychosocial, and pathophysiological similarities. Considerable evidence is emerging to support a concept that experiencing significant threatening adverse events creates a state of hypervigilance in the nervous system, which associates with exaggerated response to future threats and episodic attacks of migraine and IBS. While this sensitizing response is generally considered to reside in the central nervous system, it may be possible that the initiation resides in the enteric nervous system as well. What appears to link migraine, IBS, and CD is a disease model of a genetically sensitive nervous system transformed into one that is hypervigilant, and that over time can often develop disabling and pervasive disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Pain and Headache Reports Springer Journals

The Bowel and Migraine: Update on Celiac Disease and Irritable Bowel Syndrome

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Publisher
Current Science Inc.
Copyright
Copyright © 2012 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Internal Medicine; Pain Medicine
ISSN
1531-3433
eISSN
1534-3081
D.O.I.
10.1007/s11916-012-0258-y
Publisher site
See Article on Publisher Site

Abstract

This article explores possible relationships between migraine, irritable bowel syndrome (IBS), celiac disease (CD), and gluten sensitivity. These seemingly distinct medical entities curiously share many common epidemiological, psychosocial, and pathophysiological similarities. Considerable evidence is emerging to support a concept that experiencing significant threatening adverse events creates a state of hypervigilance in the nervous system, which associates with exaggerated response to future threats and episodic attacks of migraine and IBS. While this sensitizing response is generally considered to reside in the central nervous system, it may be possible that the initiation resides in the enteric nervous system as well. What appears to link migraine, IBS, and CD is a disease model of a genetically sensitive nervous system transformed into one that is hypervigilant, and that over time can often develop disabling and pervasive disease.

Journal

Current Pain and Headache ReportsSpringer Journals

Published: Mar 25, 2012

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