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Host factors are important in determining clinical outcomes of Helicobacter pylori infection



J Gastroenterol 2006; 41:1–9 DOI 10.1007/s00535-005-1743-4 Review Host factors are important in determining clinical outcomes of Helicobacter pylori infection Tsutomu Chiba1, Hiroshi Seno1, Hiroyuki Marusawa1, Yoshio Wakatsuki2, and Kazuichi Okazaki3 Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kawahara-cho 54, Shogoin, Sakyo, Kyoto 606-8507, Japan 2 Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan 3 Department of Gastroenterology, Kansai Medical University, Osaka, Japan Key words: H. pylori, gastritis, peptic ulcer, gastric cancer, MALT lymphoma Introduction Nearly half the population in Japan is infected with Helicobacter pylori, and consequently the prevalence of gastric cancer is very high. Not everyone with H. pylori infection develops gastric cancer, however. Indeed, the relationship between H. pylori infection and gastric cancer is quite different from that between hepatitis C virus infection and hepatocellular carcinoma. Uemura et al. reported that gastric cancer developed in approximately 3% of H. pylori-infected patients during a 7.8-year follow-up period,1 whereas the annual incidence of hepatocellular carcinoma in cirrhotic patients with hepatitis C virus infection was 2.0%–6.6%.2 Moreover, although the prevalence of H. pylori infection is similarly high in Asian countries, the incidence of gastric cancer in southern Asia is clearly lower



Journal of GastroenterologySpringer Journals

Published: Jan 1, 2006

DOI: 10.1007/s00535-005-1743-4

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