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S. Yoshihara, X. Geng, S. Okamoto, Kei Yura, Takashi Murata, Mitiko Go, Masayuki Ohmori, Masahiko Ikeuchi (2001)
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.Plant & cell physiology, 42 1
S. Reumann, J. Dávila-Aponte, K. Keegstra (1999)
The evolutionary origin of the protein-translocating channel of chloroplastic envelope membranes: identification of a cyanobacterial homolog.Proceedings of the National Academy of Sciences of the United States of America, 96 2
, Kennelly P ( eds ) Final Program VIIth Cyanobacterial Workshop
C. Wolk, A. Vonshak, Patricia Kehoe, J. Elhai (1984)
Construction of shuttle vectors capable of conjugative transfer from Escherichia coli to nitrogen-fixing filamentous cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America, 81 5
T. Thiel, E. Lyons, J. Erker, A. Ernst (1995)
A second nitrogenase in vegetative cells of a heterocyst-forming cyanobacterium.Proceedings of the National Academy of Sciences of the United States of America, 92 20
W. Vermaas (1998)
Gene modifications and mutation mapping to study the function of photosystem II.Methods in enzymology, 297
Jinsong Zhu, R. Kong, C. Wolk (1998)
Regulation of hepA ofAnabaena sp. Strain PCC 7120 by Elements 5′ from the Gene and by hepKJournal of Bacteriology, 180
M. Miyake, Kazuya Takase, Midori Narato, Emir Khatipov, J. Schnackenberg, M. Shirai, R. Kurane, Y. Asada (2000)
Polyhydroxybutyrate production from carbon dioxide by cyanobacteriaApplied Biochemistry and Biotechnology, 84-86
M. Tichý, W. Vermaas (2000)
Combinatorial mutagenesis and pseudorevertant analysis to characterize regions in loop E of the CP47 protein in Synechocystis sp. PCC 6803.European journal of biochemistry, 267 20
G. Schmetterer, C. Wolk, J. Elhai (1986)
Expression of luciferases from Vibrio harveyi and Vibrio fischeri in filamentous cyanobacteriaJournal of Bacteriology, 167
R. Simon (1976)
The biosynthesis of multi-L-arginyl-poly(L-aspartic acid) in the filamentous cyanobacterium Anabaena cylindrica.Biochimica et biophysica acta, 422 2
P. Tamagnini, J. Costa, Lígia Almeida, M. Oliveira, R. Salema, P. Lindblad (2000)
Diversity of Cyanobacterial Hydrogenases, a Molecular ApproachCurrent Microbiology, 40
John Williams, A. Szalay (1983)
Stable integration of foreign DNA into the chromosome of the cyanobacterium Synechococcus R2.Gene, 24 1
Hiroyuki Takenaka, Yuji Yamaguchi, S. Sakaki, K. Watarai, Norihide Tanaka, Masako Hori, Hiromi Seki, M. Tsuchida, A. Yamada, T. Nishimori, T. Morinaga (1998)
Safety evaluation of Nostoc flagelliforme (nostocales, Cyanophyceae) as a potential food.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 36 12
F. Partensky, W. Hess, D. Vaulot (1999)
Prochlorococcus, a Marine Photosynthetic Prokaryote of Global SignificanceMicrobiology and Molecular Biology Reviews, 63
(1988)
Nostoc commune Vauch . a nitrogen - fixing blue - green alga , as source of food in the Philippines
Karl Ziegler, Annette Diener, Carine Herpin, Ralf Richter, Rainer Deutzmann, W. Lockau (1998)
Molecular characterization of cyanophycin synthetase, the enzyme catalyzing the biosynthesis of the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartate (cyanophycin).European journal of biochemistry, 254 1
T. Thiel, H. Poo (1989)
Transformation of a filamentous cyanobacterium by electroporationJournal of Bacteriology, 171
H. Ohkawa, G. Price, M. Badger, T. Ogawa (2000)
Mutation of ndh Genes Leads to Inhibition of CO2 Uptake Rather than HCO3−Uptake in Synechocystis sp. Strain PCC 6803Journal of Bacteriology, 182
Xudong Xu, G. Yan, R. Kong, Xiangping Liu, L. Yu (2000)
Analysis of Expression of the Binary Toxin Genes from Bacillus sphaericus in Anabaena and the Potential in Mosquito ControlCurrent Microbiology, 41
Xiaoqiang Wu, S. Vennison, Huirong Liu, E. Ben‐Dov, A. Zaritsky, S. Boussiba (1997)
Mosquito larvicidal activity of transgenic Anabaena strain PCC 7120 expressing combinations of genes from Bacillus thuringiensis subsp. israelensisApplied and Environmental Microbiology, 63
T. Matsunaga, Harciko Takeyama, N. Nakamura (1990)
Characterization of cryptic plasmids from marine cyanobacteria and construction of a hybrid plasmid potentially capable of transformation of marine cyanobacterium,Synechococcus sp., and its transformationApplied Biochemistry and Biotechnology, 24-25
R. Yu, A. Yamada, Kazuo Watanabe, K. Yazawa, H. Takeyama, T. Matsunaga, R. Kurane (2000)
Production of eicosapentaenoic acid by a recombinant marine cyanobacterium, Synechococcus sp.Lipids, 35
(1999)
Cyanobacterial H 2metabolism : knowledge and potential / strategies for a photobiotechnological production of H 2
T. Rujan, W. Martin (2001)
How many genes in Arabidopsis come from cyanobacteria? An estimate from 386 protein phylogenies.Trends in genetics : TIG, 17 3
D.A Sveshnikov, N.V Sveshnikova, K.K Rao, D. Hall (1997)
Hydrogen metabolism of mutant forms of Anabaena variabilis in continuous cultures and under nutritional stressFems Microbiology Letters, 147
A. Singh, L. Sherman (2000)
Identification of Iron-Responsive, Differential Gene Expression in the Cyanobacterium Synechocystis sp. Strain PCC 6803 with a Customized Amplification LibraryJournal of Bacteriology, 182
H. Pakrasi, John Williams, C. Arntzen (1988)
Targeted mutagenesis of the psbE and psbF genes blocks photosynthetic electron transport: evidence for a functional role of cytochrome b559 in photosystem II.The EMBO Journal, 7
R. Simon (1973)
Measurement of the Cyanophycin Granule Polypeptide Contained in the Blue-Green Alga Anabaena cylindricaJournal of Bacteriology, 114
C. Richmond, J. Glasner, R. Mau, Hongfan Jin, F. Blattner (1999)
Genome-wide expression profiling in Escherichia coli K-12.Nucleic acids research, 27 19
S. Stevens, R. Porter (1980)
Transformation in Agmenellum quadruplicatum.Proceedings of the National Academy of Sciences of the United States of America, 77 10
N. Sorkhoh, R. Al-Hasan, S. Radwan, T. Höpner (1992)
Self-cleaning of the GulfNature, 359
C. Rosenberg, Julie Christian, T. Bricker, C. Putnam-Evans (1999)
Site-directed mutagenesis of glutamate residues in the large extrinsic loop of the photosystem II protein CP 43 affects oxygen-evolving activity and PS II assembly.Biochemistry, 38 48
K. Nyhus, T. Thiel, H. Pakrasi (1993)
Targeted interruption of the psaA and psaB genes encoding the reaction‐centre proteins of photosystem I in the filamentous cyanobacterium Anabaena variabilis ATCC 29413Molecular Microbiology, 9
S. Yoshihara, Fumiko Suzuki, Hironori Fujita, X. Geng, Masahiko Ikeuchi (2000)
Novel putative photoreceptor and regulatory genes Required for the positive phototactic movement of the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.Plant & cell physiology, 41 12
M. Poncelet, C. Cassier-Chauvat, X. Leschelle, H. Bottin, F. Chauvat (1998)
Targeted deletion and mutational analysis of the essential (2Fe–2S) plant‐like ferredoxin in Synechocystis PCC6803 by plasmid shufflingMolecular Microbiology, 28
Xu Xudong, Kong Renqiu, Huang Yuxiang (1993)
High larvicidal activity of intact recombinant cyanobacterium Anabaena sp. PCC 7120 expressing Gene 51 and Gene 42 of Bacillus sphaericus sp. 2297Fems Microbiology Letters, 107
C. Wolk (1996)
Heterocyst formation.Annual review of genetics, 30
J. Mrázek, D. Bhaya, A. Grossman, S. Karlin (2001)
Highly expressed and alien genes of the Synechocystis genome.Nucleic acids research, 29 7
I. Pecker, N. Ohad, J. Hirschberg (1987)
The Chloroplast-Encoded Type of Herbicide Resistance is a Recessive Trait in Cyanobacteria
L. Mikheeva, Oliver Schmitzh, S. Shestakov, H. Bothe (1995)
Mutants of the Cyanobacterium Anabaena variabilis Altered in Hydrogenase ActivitiesZeitschrift für Naturforschung C, 50
R. Singh, D. Tiwari (1969)
Induction by Ultraviolet Irradiation of Mutation in the Blue–Green Alga Nostoc linckia (Roth) Born. et Flah.Nature, 221
L. Pieulle, G. Guedeney, C. Cassier-Chauvat, R. Jeanjean, F. Chauvat, G. Peltier (2000)
The gene encoding the NdhH subunit of type 1 NAD(P)H dehydrogenase is essential to survival of Synechocystis PCC6803FEBS Letters, 487
M. Megharaj, Kadiyala Venkateswarlu, A. Rao (1987)
Metabolism of monocrotophos and quinalphos by algae isolated from soilBulletin of Environmental Contamination and Toxicology, 39
C. Hondel, S. Verbeek, A. Ende, P. Weisbeek, W. Borrias, G. Arkel (1980)
Introduction of transposon Tn901 into a plasmid of Anacystis nidulans: preparation for cloning in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America, 77 3
H. Papen, T. Kentemich, T. Schmülling, H. Bothe (1986)
Hydrogenase activities in cyanobacteria.Biochimie, 68 1
N. Sorkhoh, R. Al-Hasan, M. Khanafer, S. Radwan (1995)
Establishment of oil-degrading bacteria associated with cyanobacteria in oil-polluted soil.The Journal of applied bacteriology, 78 2
Ho-Sung Yoon, J. Golden (1998)
Heterocyst pattern formation controlled by a diffusible peptide.Science, 282 5390
Kay Marin, E. Zuther, T. Kerstan, A. Kunert, M. Hagemann (1998)
The ggpS Gene from Synechocystis sp. Strain PCC 6803 Encoding Glucosyl-Glycerol-Phosphate Synthase Is Involved in Osmolyte SynthesisJournal of Bacteriology, 180
G. Taroncher-Oldenburg, G. Stephanopoulos (2000)
Targeted, PCR-based gene disruption in cyanobacteria: inactivation of the polyhydroxyalkanoic acid synthase genes in Synechocystis sp. PCC6803Applied Microbiology and Biotechnology, 54
K. Yura, H. Toh, M. Go (1999)
Putative mechanism of natural transformation as deduced from genome data.DNA research : an international journal for rapid publication of reports on genes and genomes, 6 2
O. Schmitz, G. Boison, Ralf Hilscher, Barbara Hundeshagen, Wolfgang Zimmer, Fnedrich Lottspeich, Hermann Bothe (1995)
Molecular biological analysis of a bidirectional hydrogenase from cyanobacteria.European journal of biochemistry, 233 1
D. Tiwari (1978)
THE HETEROCYSTS OF THE BLUE-GREEN ALGA NOSTOCHOPSIS LOBATUS: EFFECTS OF CULTURAL CONDITIONSNew Phytologist, 81
T. Kaneko, Yasukazu Nakamura, C. Wolk, T. Kuritz, S. Sasamoto, A. Watanabe, Mayumi Iriguchi, Atsuko Ishikawa, K. Kawashima, Takaharu Kimura, Y. Kishida, Mitsuyo Kohara, M. Matsumoto, A. Matsuno, A. Muraki, N. Nakazaki, Sayaka Shimpo, M. Sugimoto, Masaki Takazawa, M. Yamada, Miho Yasuda, S. Tabata (2001)
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.DNA research : an international journal for rapid publication of reports on genes and genomes, 8 5
M. Tichý, W. Vermaas (1999)
In Vivo Role of Catalase-Peroxidase inSynechocystis sp. Strain PCC 6803Journal of Bacteriology, 181
M. Schena, D. Shalon, Ronald Davis, P. Brown (1995)
Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA MicroarrayScience, 270
R. Murphy, S. Stevens (1992)
Cloning and expression of the cryIVD gene of Bacillus thuringiensis subsp. israelensis in the cyanobacterium Agmenellum quadruplicatum PR-6 and its resulting larvicidal activityApplied and Environmental Microbiology, 58
C. Wilkinson, P. Fay (1979)
Nitrogen fixation in coral reef sponges with symbiotic cyanobacteriaNature, 279
Elena Casey, Arthur Grossman (1994)
In vivo and in vitro characterization of the light-regulated cpcB2A2 promoter of Fremyella diplosiphonJournal of Bacteriology, 176
K. Sode, M. Tatara, S. Ogawa, T. Matsunaga (1992)
Maintenance of broad host range vector pKT230 in marine unicellular cyanobacteriaFems Microbiology Letters, 99
L. Rouhiainen, L. Paulin, S. Suomalainen, H. Hyytiäinen, W. Buikema, R. Haselkorn, K. Sivonen (2000)
Genes encoding synthetases of cyclic depsipeptides, anabaenopeptilides, in Anabaena strain 90Molecular Microbiology, 37
T. Thiel (1994)
Genetic Analysis of Cyanobacteria
C. Wolk, Y. Cai, J. Panoff (1991)
Use of a transposon with luciferase as a reporter to identify environmentally responsive genes in a cyanobacterium.Proceedings of the National Academy of Sciences of the United States of America, 88
Jung-Fu Wu, W. Pond (1981)
Amino acid composition and microbial contamination ofSpirulina maxima, a blue-green alga, grown on the effluent of different fermented animal wastesBulletin of Environmental Contamination and Toxicology, 27
P. Marraccini, C. Cassier-Chauvat, S. Bulteau, S. Chávez, F. Chauvat (1994)
Light‐regulated promoters from Synechocystis PCC6803 share a consensus motif involved in photoregulationMolecular Microbiology, 12
Isabelle Thiery, L. Nicolas, R. Rippka, N. Marsac (1991)
Selection of cyanobacteria isolated from mosquito breeding sites as a potential food source for mosquito larvaeApplied and Environmental Microbiology, 57
Xu-Dong Xu, C. Wolk (2001)
Role for hetC in the Transition to a Nondividing State during Heterocyst Differentiation inAnabaena spJournal of Bacteriology, 183
N. Tsinoremas, A. Kutach, C. Strayer, S. Golden (1994)
Efficient gene transfer in Synechococcus sp. strains PCC 7942 and PCC 6301 by interspecies conjugation and chromosomal recombinationJournal of Bacteriology, 176
T. Sazuka, O. Ohara (1997)
Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: Linking 130 protein spots with their respective genesELECTROPHORESIS, 18
G. Taroncher-Oldenburg, Koren Nishina, G. Stephanopoulos (2000)
Identification and Analysis of the Polyhydroxyalkanoate-Specific β-Ketothiolase and Acetoacetyl Coenzyme A Reductase Genes in the Cyanobacterium Synechocystis sp. Strain PCC6803Applied and Environmental Microbiology, 66
C. Wolk, J. Elhai, T. Kuritz, D. Holland (1993)
Amplified expression of a transcriptional pattern formed during development of AnabaenaMolecular Microbiology, 7
M. Vega-Palas, Francisco Madueño, A. Herrero, E. Flores (1990)
Identification and cloning of a regulatory gene for nitrogen assimilation in the cyanobacterium Synechococcus sp. strain PCC 7942Journal of Bacteriology, 172
R. Simon (1971)
Cyanophycin Granules from the Blue-Green Alga Anabaena cylindrica: A Reserve Material Consisting of Copolymers of Aspartic Acid and Arginine.Proceedings of the National Academy of Sciences of the United States of America, 68 2
I. Suzuki, D. Los, Y. Kanesaki, K. Mikami, Norio Murata (2000)
The pathway for perception and transduction of low‐temperature signals in SynechocystisThe EMBO Journal, 19
C. Wolk, Y. Cai, L. Cardemil, E. Flores, '. Hohn, M. Murry, G. Schmetterer, B. Schrautemeier, Ruth Wilson (1988)
Isolation and complementation of mutants of Anabaena sp. strain PCC 7120 unable to grow aerobically on dinitrogenJournal of Bacteriology, 170
J. Thor, Owin Gruters, H. Matthijs, K. Hellingwerf (1999)
Localization and function of ferredoxin:NADP+ reductase bound to the phycobilisomes of SynechocystisThe EMBO Journal, 18
S. Golden, L. Sherman (1984)
Optimal conditions for genetic transformation of the cyanobacterium Anacystis nidulans R2Journal of Bacteriology, 158
I. Suzuki, Y. Kanesaki, K. Mikami, M. Kanehisa, N. Murata (2001)
Cold‐regulated genes under control of the cold sensor Hik33 in SynechocystisMolecular Microbiology, 40
E. Soltes-Rak, D. Kushner, D. Williams, J. Coleman (1993)
Effect of promoter modification on mosquitocidal cryIVB gene expression in Synechococcus sp. strain PCC 7942Applied and Environmental Microbiology, 59
A. Vachhani, R. Iyer, R. Tuli (1993)
A Mobilizable Shuttle Vector for the Cyanobacterium Plectonema BoryanumMicrobiology, 139
T. Marsac, W. Borrias, C. Kuhlemeier, A. Caste, G. Arkel, C. Hondel (2002)
A new approach for molecular cloning in Cyanobacteria: cloning of an Anucystis nidrrlans met gene using a Tn9024nduced mutant
I. Zhulin (2000)
A novel phototaxis receptor hidden in the cyanobacterial genome.Journal of molecular microbiology and biotechnology, 2 4
J. Reaston, Marja Duyvesteyn, A. Waard (1982)
Nostoc PCC7524, a cyanobacterium which contains five sequence-specific deoxyribonucleases.Gene, 20 1
A. Matveyev, K. Young, A. Meng, J. Elhai (2001)
DNA methyltransferases of the cyanobacterium Anabaena PCC 7120.Nucleic acids research, 29 7
J. Vinnemeier, Martin Hagemann (1999)
Identification of salt-regulated genes in the genome of the cyanobacterium Synechocystis sp. strain PCC 6803 by subtractive RNA hybridizationArchives of Microbiology, 172
M. Narro, C. Cerniglia, C. Baalen, D. Gibson (1992)
Metabolism of phenanthrene by the marine cyanobacterium Agmenellum quadruplicatum PR-6Applied and Environmental Microbiology, 58
G. Patterson, C. Baldwin, C. Bolis, F. Caplan, H. Karuso, L. Larsen, I. Levine, R. Moore, Carrie Nelson, K. Tschappat, Grace Tuang, E. Furusawa, S. Furusawa, T. Norton, R. Raybourne (1991)
ANTINEOPLASTIC ACTIVITY OF CULTURED BLUE‐GREEN ALGAE (CYANOPHYTA) 1Journal of Phycology, 27
A. Rimon, A. Oppenheim (1975)
Heat induction of the blue-green alga Plectonema boryanum lysogenic for the cyanophage SPlcts1.Virology, 64 2
T. Sarma, B. Kaur (1997)
Characterization of host-range mutants of cyanophage N-1.Acta virologica, 41 5
P. Prentki, A. Binda, A. Epstein (1991)
Plasmid vectors for selecting IS1-promoted deletions in cloned DNA: sequence analysis of the omega interposon.Gene, 103 1
W. Vermaas, J. Charité, G. Shen (1990)
Glu-69 of the D2 protein in photosystem II is a potential ligand to Mn involved in photosynthetic oxygen evolution.Biochemistry, 29 22
L. Sherman, R. Brown (1978)
Cyanophages and Viruses of Eukaryotic Algae
Steven Schwartz, T. Black, K. Jäger, J. Panoff, C. Wolk (1998)
Regulation of an Osmoticum-Responsive Gene in Anabaena sp. Strain PCC 7120Journal of Bacteriology, 180
M. Herdman, M. Janvier, R. Rippka, R. Stanier (1979)
Genome Size of CyanobacteriaMicrobiology, 111
Y. Narusaka, M. Narusaka, Hirokazu Kobayashi, Kimiyuki Satoh (1998)
The herbicide-resistant species of the cyanobacterial D1 protein obtained by thorough and random in vitro mutagenesis.Plant & cell physiology, 39 6
G. Shen, S. Boussiba, W. Vermaas (1993)
Synechocystis sp PCC 6803 strains lacking photosystem I and phycobilisome function.The Plant cell, 5 12
J. Alda, J. Houmard (2000)
Genomic survey of cAMP and cGMP signalling components in the cyanobacterium Synechocystis PCC 6803.Microbiology, 146 Pt 12
N. Zhao, H. Hashida, Nobuaki Takahashi, Y. Misumi, Y. Sakaki (1995)
High-density cDNA filter analysis: a novel approach for large-scale, quantitative analysis of gene expression.Gene, 156 2
D. Billi, E. Friedmann, Richard Helm, M. Potts (2001)
Gene Transfer to the Desiccation-Tolerant CyanobacteriumChroococcidiopsisJournal of Bacteriology, 183
G. D'alessio, J. Riordan (1997)
Ribonucleases : structures and functions
M. Montesinos, A. Herrero, E. Flores (1997)
Amino acid transport in taxonomically diverse cyanobacteria and identification of two genes encoding elements of a neutral amino acid permease putatively involved in recapture of leaked hydrophobic amino acidsJournal of Bacteriology, 179
T. Sazuka, M. Yamaguchi, O. Ohara (1999)
Cyano2Dbase updated: linkage of 234 protein spots to corresponding genes through N-terminal microsequencing.Electrophoresis, 20 11
Yi Liu, S. Golden, T. Kondo, M. Ishiura, C. Johnson (1995)
Bacterial luciferase as a reporter of circadian gene expression in cyanobacteriaJournal of Bacteriology, 177
R. Rippka, Josette Deruelles, J. Waterbury, M. Herdman, R. Stanier (1979)
Generic assignments, strain histories, and properties of pure cultures of cyanobacteriaMicrobiology, 111
Cyanobacteria are oxygenic photosynthetic bacteria that have been used increasingly to study diverse biological processes, including photosynthesis and its regulation; cell differentiation and N2 fixation; metabolism of nitrogen, carbon, and hydrogen; resistance to environmental stresses; and molecular evolution. Many vectors and other genetic tools have been developed for unicellular and filamentous strains of cyanobacteria. Transformation, electroporation, and conjugation are used for gene transfer. Diverse methods of mutagenesis allow the isolation of many sought-for kinds of mutants, including site-directed mutants of specific genes. Reporter genes permit measurement of the level of transcription of particular genes, and assays of transcription within individual colonies or within individual cells in a filament. Complete genomic sequences have been obtained for the unicellular cyanobacterium, Synechocystis sp. strain PCC 6803 and the filamentous, heterocyst-forming cyanobacterium, Anabaena sp. strain PCC 7120. Genomic sequence projects are under way for Nostoc punctiforme strain PCC 73102 (ATCC 29133) and strains of the unicellular genera, Synechococcus, Prochlorococcus, and Gloeobacter. Genomic sequence data provide the opportunity for global monitoring of changes in genetic expression at transcriptional and translational levels in response to variations in environmental conditions. The availability of genomic sequences accelerates the identification, study, modification and comparison of cyanobacterial genes, and facilitates analysis of evolutionary relationships, including the relationship of chloroplasts to ancient cyanobacteria. The many available genetic tools enhance the opportunities for possible biotechnological applications of cyanobacteria.
Applied Microbiology and Biotechnology – Springer Journals
Published: Jan 1, 2002
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