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Hicks Rd (1989)
Cocaine abuse and its treatment.Hawaii medical journal, 48 11
C. Johanson, C. Schuster (1975)
A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey.The Journal of pharmacology and experimental therapeutics, 193 2
R. Balster, R. Balster, C. Schuster (1973)
Fixed-interval schedule of cocaine reinforcement: effect of dose and infusion duration.Journal of the experimental analysis of behavior, 20 1
(1987)
Reinforcing and discriminative stimulus effects of cocaine: analysis of pharmacological mechanisms
N. Volkow, N. Volkow, Gene-Jack Wang, M. Fischman, R. Foltin, J. Fowler, N. Abumrad, S. Vitkun, J. Logan, S. Gatley, N. Pappas, R. Hitzemann, C. Shea (1997)
Relationship between subjective effects of cocaine and dopamine transporter occupancyNature, 386
Mark Gold (1993)
Opiate addiction and the locus coeruleus. The clinical utility of clonidine, naltrexone, methadone, and buprenorphine.The Psychiatric clinics of North America, 16 1
S. Goldberg, R. Spealman, R. Kelleher (1979)
Enhancement of drug-seeking behavior by environmental stimuli associated with cocaine or morphine injectionsNeuropharmacology, 18
J. Glowa, F. Wojnicki, D. Matecka, J. Bacher, R. Mansbach, R. Balster, K. Rice (1995)
Effects of dopamine reuptake inhibitors on food- and cocaine-maintained responding: I. Dependence on unit dose of cocaine.Experimental and Clinical Psychopharmacology, 3
J. Katz, A. Newman, S. Izenwasser (1997)
Relations Between Heterogeneity of Dopamine Transporter Binding and Function and the Behavioral Pharmacology of CocainePharmacology Biochemistry and Behavior, 57
D. Paly, P. Jatlow, C. Dyke, F. Jerí, R. Byck (1982)
Plasma cocaine concentrations during cocaine paste smoking.Life sciences, 30 9
R. Ettinger, W. Ettinger, Wendy Harless (1997)
Active Immunization with Cocaine–Protein Conjugate Attenuates Cocaine EffectsPharmacology Biochemistry and Behavior, 58
T. Kosten, C. Morgan, H. Kleber (1991)
Treatment of heroin addicts using buprenorphine.The American journal of drug and alcohol abuse, 17 2
R. Peltier, S. Schenk (1991)
GR38032F, a serotonin 5-HT3 antagonist, fails to alter cocaine self-administration in ratsPharmacology Biochemistry and Behavior, 39
C. Johanson, M. Fischman (1989)
The pharmacology of cocaine related to its abuse.Pharmacological reviews, 41 1
Neal Benowitz (1993)
Clinical pharmacology and toxicology of cocaine.Pharmacology & toxicology, 72 1
S. Singh, G. Basmadjian, K. Avor, B. Pouw, T. Seale (1997)
Synthesis and ligand binding studies of 4'-iodobenzoyl esters of tropanes and piperidines at the dopamine transporter.Journal of medicinal chemistry, 40 16
M. Carrera, J. Ashley, L. Parsons, P. Wirsching, G. Koob, K. Janda (1995)
Suppression of psychoactive effects of cocaine by active immunizationNature, 378
S. Caine, G. Koob (1994)
Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.The Journal of pharmacology and experimental therapeutics, 270 1
S. Goldberg (1973)
Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey.The Journal of pharmacology and experimental therapeutics, 186 1
L. Dickerson, D. Rodak, F. Kuhn, S. Wahlstrom, R. Tessel, M. Visner, G. Schaer, R. Gillis (1999)
Cocaine-induced cardiovascular effects: lack of evidence for a central nervous system site of action based on hemodynamic studies with cocaine methiodide.Journal of cardiovascular pharmacology, 33 1
M. Kreek (1992)
Rationale for maintenance pharmacotherapy of opiate dependence.Research publications - Association for Research in Nervous and Mental Disease, 70
W. Pan, M. Hedaya (1999)
Cocaine and alcohol interactions in the rat: contribution of cocaine metabolites to the pharmacological effects.Journal of pharmaceutical sciences, 88 4
B. Mets, G. Winger, C. Cabrera, S. Seo, S. Jamdar, G. Yang, K. Zhao, R. Briscoe, R. Almonte, J. Woods, D. Landry (1998)
A catalytic antibody against cocaine prevents cocaine's reinforcing and toxic effects in rats.Proceedings of the National Academy of Sciences of the United States of America, 95 17
R. Balster, C. Schuster (1973)
A comparison of d-amphetamine, l-amphetamine, and methamphetamine self-administration in rhesus monkeys.Pharmacology, biochemistry, and behavior, 1 1
R. Kelleher (1966)
Conditioned reinforcement in second-order schedules.Journal of the experimental analysis of behavior, 9 5
S. Goldberg, R. Kelleher, D. Goldberg (1981)
Fixed-ratio responding under second-order schedules of food presentation or cocaine injection.The Journal of pharmacology and experimental therapeutics, 218 1
J. Bergman, J. Kamien, R. Spealman (1990)
Antagonism of cocaine self‐administration by selective dopamine D1 and D2 antagonistsBehavioural Pharmacology, 1
K. Bonese, B. Wainer, F. Fitch, R. Rothberg, C. Schuster (1974)
Changes in heroin self-administration by a rhesus monkey after morphine immunisationNature, 252
B. Fox, K. Kantak, M. Edwards, Kerry Black, B. Bollinger, Alison Botka, T. French, Terry Thompson, V. Schad, J. Greenstein, M. Gefter, M. Exley, P. Swain, T. Briner (1996)
Efficacy of a therapeutic cocaine vaccine in rodent modelsNature Medicine, 2
(1994)
Chemical approaches to the treatment of cocaine abuse
R. Kelleher (1966)
CONDITIONED REINFORCEMENT IN SECOND‐ORDER SCHEDULES1Journal of the Experimental Analysis of Behavior, 9
S. Sparenborg, F. Vocci, S. Zukin (1997)
Peripheral cocaine-blocking agents: new medications for cocaine dependence1The views and opinions expressed herein are those of the authors and do not necessarily reflect policies of the National Institute on Drug Abuse.1Drug and Alcohol Dependence, 48
R. Booze, R. Booze, Andreas Lehner, David Wallace, M. Welch, C. Mactutus (1997)
Dose-response cocaine pharmacokinetics and metabolite profile following intravenous administration and arterial sampling in unanesthetized, freely moving male rats.Neurotoxicology and teratology, 19 1
Charles O'Brien (1997)
A range of research-based pharmacotherapies for addiction.Science, 278 5335
Donald Landry, K. Zhao, Ginger Yang, Michael Glickman, T. Georgiadis (1993)
Antibody-catalyzed degradation of cocaine.Science, 259 5103
H. Morishima, R. Whittington, A. Iso, T. Cooper (1999)
The comparative toxicity of cocaine and its metabolites in conscious rats.Anesthesiology, 90 6
(1999)
Comparison of the effects of the cocaine vaccine IPC-1010 on responding maintained by cocaine and food delivery (abstract)
R. Wise, R. Ranaldi (1996)
Cocaine vaccines revisitedNature Medicine, 2
Rationale: Previous pre-clinical studies with an anti-cocaine monoclonal antibody left open several issues critical to assessing the effectiveness of a vaccine for altering cocaine self-administration behavior. Objectives: The objectives of this study were to determine, first, whether changes in self-administration behavior would be systematically related to antibody level and, second, how the antibody affected the self-administration of different doses of cocaine. Methods: Two experiments were conducted using a second-order schedule of drug delivery in rats. The first was a passive-administration study using the anti-cocaine monoclonal antibody MO240 to examine the relationship between antibody level and cocaine self-administration behavior, and the second was an active-immunization study to examine the efficacy of the cocaine vaccine IPC-1010 for blocking various doses of self-administered cocaine. Results: The passive-administration experiment with control and 4-mg or 12-mg MO240 treatments showed that antagonism of the 1 mg/kg cocaine training dose was dependent on antibody level. In animals whose serum antibody levels were sustained above 0.05 mg/ml, there was a sufficient amount of antibody to reduce drug-seeking behavior and drug intake. In the active-immunization experiment, the cocaine vaccine IPC-1010 induced average serum antibody levels of 0.08 mg/ml and reduced the reacquisition of behavior by 1 mg/kg cocaine. Antagonism of cocaine self-administration after immunization was evident across a range of doses of cocaine and was only apparent in animals whose serum antibody levels exceeded 0.05 mg/ml. Furthermore, there was no evidence that the antagonism was surmountable within the dose range examined (up to 5.6 mg/kg). Conclusions: Antagonism of cocaine self-administration across a range of doses is feasible after immunization with a cocaine vaccine as long as antibody levels are of a sufficient concentration.
Psychopharmacology – Springer Journals
Published: Feb 1, 2000
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