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Effect of gentamicin on abscesses caused by Bacteroides species



Eur. J. Clin. Microbiol. (Schering, Kenilworth, NJ) was administered i.m. in a dose of 7.5 mg/Kg/day, 2 h after inoculuation and at 8 h intervals thereafter for seven days, at which time the mice were sacrificed by cervical dislocation. The surface sizes Sir, Organisms belonging to the Bacteroides fragilis of the abscesses were estimated from measureand Bacteroides melaninogenicus groups are ments by caliper of two perpendicular diaimportant clinical pathogens. Encapsulated meters. The abscess material was removed strains of these groups were also capable of aseptically and homogenized inside a glove box and the number of organisms in an abscess was causing abscesses in animals (1). Aminoglycosides are often administered to determined using serial dilutions of the homopatients with life threatening infections. Failure genates and plating on enriched blood agar to respond to therapy with aminoglycosides is plates. Colonies were counted following incubaconsidered to be a well established indication tion at 37 ~ in an anaerobic chamber for 48 h. of the presence of an anaerobic infection. This The levels of the gentamicin in the sera and in association is believed to be due to the relative the abscesses was determined in each represenresistance of all anaerobic organisms to



European Journal of Clinical Microbiology Infectious DiseasesSpringer Journals

Published: Dec 1, 1983

DOI: 10.1007/BF02016578

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