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Effect of gentamicin on abscesses caused by Bacteroides species

Effect of gentamicin on abscesses caused by Bacteroides species Eur. J. Clin. Microbiol. (Schering, Kenilworth, NJ) was administered i.m. in a dose of 7.5 mg/Kg/day, 2 h after inoculuation and at 8 h intervals thereafter for seven days, at which time the mice were sacrificed by cervical dislocation. The surface sizes Sir, Organisms belonging to the Bacteroides fragilis of the abscesses were estimated from measureand Bacteroides melaninogenicus groups are ments by caliper of two perpendicular diaimportant clinical pathogens. Encapsulated meters. The abscess material was removed strains of these groups were also capable of aseptically and homogenized inside a glove box and the number of organisms in an abscess was causing abscesses in animals (1). Aminoglycosides are often administered to determined using serial dilutions of the homopatients with life threatening infections. Failure genates and plating on enriched blood agar to respond to therapy with aminoglycosides is plates. Colonies were counted following incubaconsidered to be a well established indication tion at 37 ~ in an anaerobic chamber for 48 h. of the presence of an anaerobic infection. This The levels of the gentamicin in the sera and in association is believed to be due to the relative the abscesses was determined in each represenresistance of all anaerobic organisms to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Microbiology Infectious Diseases Springer Journals

Effect of gentamicin on abscesses caused by Bacteroides species

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References (11)

Publisher
Springer Journals
Copyright
Copyright © 1983 by Vieweg Publishing
Subject
Biomedicine; Medical Microbiology; Internal Medicine
ISSN
0934-9723
eISSN
1435-4373
DOI
10.1007/BF02016578
Publisher site
See Article on Publisher Site

Abstract

Eur. J. Clin. Microbiol. (Schering, Kenilworth, NJ) was administered i.m. in a dose of 7.5 mg/Kg/day, 2 h after inoculuation and at 8 h intervals thereafter for seven days, at which time the mice were sacrificed by cervical dislocation. The surface sizes Sir, Organisms belonging to the Bacteroides fragilis of the abscesses were estimated from measureand Bacteroides melaninogenicus groups are ments by caliper of two perpendicular diaimportant clinical pathogens. Encapsulated meters. The abscess material was removed strains of these groups were also capable of aseptically and homogenized inside a glove box and the number of organisms in an abscess was causing abscesses in animals (1). Aminoglycosides are often administered to determined using serial dilutions of the homopatients with life threatening infections. Failure genates and plating on enriched blood agar to respond to therapy with aminoglycosides is plates. Colonies were counted following incubaconsidered to be a well established indication tion at 37 ~ in an anaerobic chamber for 48 h. of the presence of an anaerobic infection. This The levels of the gentamicin in the sera and in association is believed to be due to the relative the abscesses was determined in each represenresistance of all anaerobic organisms to

Journal

European Journal of Clinical Microbiology Infectious Diseases – Springer Journals

Published: Dec 1, 1983

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