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Kelly McDonald, A. Page, Sumanas Jordan, Carrie Chu, A. Hestley, K. Delman, D. Murray, G. Carlson (2013)
Analysis of regional recurrence after negative sentinel lymph node biopsy for head and neck melanomaHead & Neck, 35
A. Francken, N. Accortt, H. Shaw, M. Wiener, S. Soong, H. Hoekstra, J. Thompson (2008)
Prognosis and Determinants of Outcome Following Locoregional or Distant Recurrence in Patients with Cutaneous MelanomaAnnals of Surgical Oncology, 15
Kirsty Boyd, B. Wehrli, C. Temple (2011)
Intra‐lesional interleukin‐2 for the treatment of in‐transit melanomaJournal of Surgical Oncology, 104
P. Radny, U. Caroli, J. Bauer, T. Paul, C. Schlegel, T. Eigentler, B. Weide, M. Schwarz, C. Garbe (2003)
Phase II trial of intralesional therapy with interleukin-2 in soft-tissue melanoma metastasesBritish Journal of Cancer, 89
C. Balch, J. Gershenwald, S. Soong, J. Thompson, M. Atkins, D. Byrd, A. Buzaid, A. Cochran, D. Coit, Shouluan Ding, A. Eggermont, K. Flaherty, P. Gimotty, J. Kirkwood, K. McMasters, M. Mihm, D. Morton, M. Ross, A. Sober, V. Sondak (2009)
Final version of 2009 AJCC melanoma staging and classification.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 36
S. Kesmodel, G. Karakousis, J. Botbyl, R. Canter, Robert Lewis, P. Wahl, Kyla Terhune, A. Alavi, D. Elder, M. Ming, D. Guerry, P. Gimotty, D. Fraker, B. Czerniecki, F. Spitz (2004)
Mitotic Rate as a Predictor of Sentinel Lymph NodePositivity in Patients With Thin MelanomasAnnals of Surgical Oncology, 12
J. Baker, D. Ollila, A. Deal, J. Frank, K. Amos, M. Meyers (2012)
Early Recurrence in Sentinel Lymph Node Positive Stage III Melanoma PatientsThe American Surgeon, 78
H. Kroon, Deshuai Lin, P. Kam, J. Thompson (2009)
Efficacy of repeat isolated limb infusion with melphalan and actinomycin D for recurrent melanomaCancer, 115
D. Chang, R. Amdur, C. Morris, W. Mendenhall (2006)
Adjuvant radiotherapy for cutaneous melanoma: comparing hypofractionation to conventional fractionation.International journal of radiation oncology, biology, physics, 66 4
A. Raymond, G. Beasley, G. Broadwater, C. Augustine, J. Padussis, R. Turley, B. Peterson, H. Seigler, S. Pruitt, D. Tyler (2011)
Current trends in regional therapy for melanoma: lessons learned from 225 regional chemotherapy treatments between 1995 and 2010 at a single institution.Journal of the American College of Surgeons, 213 2
T. Wagner, C. Ahonen, Aimee Couture, S. Gibson, Richard Miller, Rosealee Smith, M. Reiter, J. Vasilakos, M. Tomai (1999)
Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod.Cellular immunology, 191 1
G. Beasley, Colin Parsons, G. Broadwater, M. Selim, Suroosh Marzban, A. Abernethy, A. Salama, E. Eikman, T. Wong, J. Zager, D. Tyler (2012)
A Multicenter Prospective Evaluation of the Clinical Utility of F-18 FDG-PET/CT in Patients With AJCC Stage IIIB or IIIC Extremity MelanomaAnnals of Surgery, 256
Wendy Cornett, L. Mccall, R. Petersen, M. Ross, H. Briele, R. Noyes, J. Sussman, W. Kraybill, J. Kane, H. Alexander, Jeffrey Lee, P. Mansfield, J. Pingpank, D. Winchester, R. White, V. Chadaram, J. Herndon, D. Fraker, D. Tyler (2006)
Randomized multicenter trial of hyperthermic isolated limb perfusion with melphalan alone compared with melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group Trial Z0020.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24 25
Travis Kidner, D. Morton, Delphine Lee, M. Hoban, L. Foshag, R. Turner, M. Faries (2012)
Combined Intralesional Bacille Calmette-Guérin (BCG) and Topical Imiquimod for In-transit MelanomaJournal of Immunotherapy, 35
A. Testori, M. Faries, J. Thompson, E. Pennacchioli, J. Deroose, A. Geel, C. Verhoef, F. Verrecchia, J. Soteldo (2011)
Local and intralesional therapy of in‐transit melanoma metastasesJournal of Surgical Oncology, 104
O. Creech, E. Krementz, R. Ryan, Winblad Jn (1958)
Chemotherapy of Cancer: Regional Perfusion Utilizing an Extracorporeal CircuitAnnals of Surgery, 148
Christy Chai, J. Deneve, G. Beasley, Suroosh Marzban, Y. Chen, B. Rawal, S. Grobmyer, S. Hochwald, D. Tyler, J. Zager (2012)
A Multi-institutional Experience of Repeat Regional Chemotherapy for Recurrent Melanoma of ExtremitiesAnnals of Surgical Oncology, 19
B. Badgwell, Y. Xing, J. Gershenwald, Jeffrey Lee, P. Mansfield, M. Ross, J. Cormier (2007)
Pelvic Lymph Node Dissection Is Beneficial in Subsets of Patients with Node-positive MelanomaAnnals of Surgical Oncology, 14
L. Kottschade, R. Weenig, C. Otley, R. McWilliams, S. Markovic (2010)
The use of pulsed dye laser in the treatment of melanoma metastatic to the skin: a Mayo Clinic case series.Journal of the American Academy of Dermatology, 62 6
D. Morton, F. Eilber, Malmgren Ra, Wood Wc (1970)
Immunological factors which influence response to immunotherapy in malignant melanoma.Surgery, 68 1
A. Testori, A. Intelisano, F. Verrecchia, C. Menicanti, G. Tosti, E. Grassi, C. Pari, E. Pennacchioli (2012)
Alternatives for the treatment of local advanced disease: electrochemotherapy, limb perfusion, limb infusion, intralesional IL2. What is the role?Dermatologic Therapy, 25
S. LeVine, R. Shapiro (2012)
Surgical treatment of malignant melanoma: practical guidelines.Dermatologic clinics, 30 3
MD WUSSOW, MD BLOCK, MD HARTMANN, MD DEICHER (1988)
Intralesional interferon‐alpha therapy in advanced malignant melanomaCancer, 61
C. Stucky, R. Gray, A. Dueck, N. Wasif, S. Laman, A. Sekulic, B. Pockaj (2010)
Risk factors associated with local and in-transit recurrence of cutaneous melanoma.American journal of surgery, 200 6
G Stevens, JF Thompson, I Firth (2000)
Locally advanced melanoma: results of postoperative hypofractionated radiation therapyCancer, 88
C. Day, T. Harrist, F. Gorstein, A. Sober, R. Lew, R. Friedman, A. Kopf, T. Fitzpatrick, M. Mihm (1981)
Malignant Melanoma: Prognostic Significance of “Microscopic Satellites” in the Reticular Dermis and Subcutaneous FatAnnals of Surgery, 194
Brian Berman, Poochareon Vn, Villa Am (2002)
Novel dermatologic uses of the immune response modifier imiquimod 5% cream.Skin therapy letter, 7 9
G. Beasley, D. Tyler (2011)
Treatment of in-transit melanoma: an opportunity to discover critical knowledge.Oncology, 25 14
M. Pace, R. Gattai, Erminia Mascitelli, L. Millanta (2011)
Results of isolated lower limb perfusion for loco‐regional advanced/recurrent melanoma using borderline true hyperthermia plus additional bolus of melphalan. A critical analysis of homogeneous casesJournal of Surgical Oncology, 104
F. Martiniuk, D. Damian, J. Thompson, R. Scolyer, K. Tchou-Wong, W. Levis (2010)
TH17 is involved in the remarkable regression of metastatic malignant melanoma to topical diphencyprone.Journal of drugs in dermatology : JDD, 9 11
H. Kroon, M. Moncrieff, P. Kam, J. Thompson (2008)
Outcomes Following Isolated Limb Infusion for Melanoma. A 14-Year ExperienceAnnals of Surgical Oncology, 15
K. Yao, E. Hsueh, R. Essner, L. Foshag, L. Wanek, D. Morton (2003)
Is Sentinel Lymph Node Mapping Indicated for Isolated Local and In-Transit Recurrent Melanoma?Annals of Surgery, 238
A. Shada, D. Walters, S. Tierney, C. Slingluff (2012)
Surgical resection for bulky or recurrent axillary metastatic melanomaJournal of Surgical Oncology, 105
A. Testori, C. Verhoef, H. Kroon, Elisabetta Pennacchioli, M. Faries, A. Eggermont, John Thompson (2011)
Treatment of melanoma metastases in a limb by isolated limb perfusion and isolated limb infusionJournal of Surgical Oncology, 104
S. Young, S. Martinez, M. Faries, R. Essner, L. Wanek, D. Morton (2006)
Can Surgical Therapy Alone Achieve Long‐Term Cure of Melanoma Metastatic to Regional Nodes?The Cancer Journal, 12
G. Beasley, R. Petersen, Jin Yoo, N. McMahon, T. Aloia, W. Petros, G. Sanders, T. Cheng, S. Pruitt, H. Seigler, D. Tyler (2008)
Isolated Limb Infusion for In-Transit Malignant Melanoma of the Extremity: A Well-Tolerated but Less Effective Alternative to Hyperthermic Isolated Limb PerfusionAnnals of Surgical Oncology, 15
G. Stevens, J. Thompson, I. Firth, C. O'brien, W. McCarthy, M. Quinn (2020)
Locally advanced melanomaCancer, 88
L. Ridolfi, R. Ridolfi (2002)
Preliminary experiences of intralesional immunotherapy in cutaneous metastatic melanoma.Hepato-gastroenterology, 49 44
M. Gimbel, K. Delman, J. Zager (2008)
Therapy for unresectable recurrent and in-transit extremity melanoma.Cancer control : journal of the Moffitt Cancer Center, 15 3
H. Hemmi, T. Kaisho, O. Takeuchi, Shintaro Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, S. Akira (2002)
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathwayNature Immunology, 3
J. Wong, Y. Chen, Kate Fisher, J. Zager (2013)
Isolated Limb Infusion in a Series of Over 100 Infusions: A Single-Center ExperienceAnnals of Surgical Oncology, 20
S. Agrawal, J. Kane, B. Guadagnolo, W. Kraybill, M. Ballo (2009)
The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high‐risk, lymph node‐metastatic melanomaCancer, 115
Timothy Love, K. Delman (2010)
Management of regional lymph node basins in melanoma.The Ochsner journal, 10 2
Karakousis Cp, Cho Kj, Holyoke Ed (1980)
Biologic behavior and treatment of intransit metastasis of melanoma.Surgery gynecology & obstetrics, 150
X. Dong, D. Tyler, Jeffrey Johnson, P. Dematos, H. Seigler (2000)
Analysis of prognosis and disease progression after local recurrence of melanomaCancer, 88
E. Jones, Teresa Jones, N. Pearlman, D. Gao, Robert Stovall, C. Gajdos, N. Kounalakis, R. Gonzalez, K. Lewis, W. Robinson, M. McCarter (2013)
Long-term follow-up and survival of patients following a recurrence of melanoma after a negative sentinel lymph node biopsy result.JAMA surgery, 148 5
C. Barker, N. Lee (2012)
Radiation therapy for cutaneous melanoma.Dermatologic clinics, 30 3
D. Damian, J. Thompson (2007)
Treatment of extensive cutaneous metastatic melanoma with topical diphencyprone.Journal of the American Academy of Dermatology, 56 5
W. Sause, J. Cooper, S. Rush, C. Ago, D. Cosmatos, C. Coughlin, N. Janjan, J. Lipsett (1991)
Fraction size in external beam radiation therapy in the treatment of melanoma.International journal of radiation oncology, biology, physics, 20 3
T. Zogakis, R. Essner, He-jing Wang, L. Foshag, D. Morton (2007)
Natural History of Melanoma in 773 Patients with Tumor-Negative Sentinel Lymph NodesAnnals of Surgical Oncology, 14
R. Chowdhery, R. Gonzalez (2011)
Immunologic therapy targeting metastatic melanoma: allovectin-7.Immunotherapy, 3 1
F. Collichio, T. Amatruda, N. Senzer, J. Chesney, K. Delman, L. Spitler, I. Puzanov, S. Doleman, Y. Ye, A. Vanderwalde, R. Coffin, H. Kaufman (2013)
OPTiM: A randomized phase III trial of talimogene laherparepvec (T-VEC) versus subcutaneous (SC) granulocyte-macrophage colony-stimulating factor (GM-CSF) for the treatment (tx) of unresected stage IIIB/C and IV melanoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31 18_suppl
Ketan Sharma, G. Beasley, R. Turley, A. Raymond, G. Broadwater, B. Peterson, P. Mosca, D. Tyler (2012)
Patterns of Recurrence Following Complete Response to Regional Chemotherapy for In-Transit MelanomaAnnals of Surgical Oncology, 19
T. Fujimura, R. Okuyama, T. Ohtani, Y. Ito, T. Haga, A. Hashimoto, S. Aiba (2009)
Perilesional treatment of metastatic melanoma with interferon‐βClinical and Experimental Dermatology, 34
J. Thompson, P. Kam, P. Kam, R. Waugh, C. Harman (1998)
Isolated limb infusion with cytotoxic agents: a simple alternative to isolated limb perfusion.Seminars in surgical oncology, 14 3
Grant Carlson, Andrew Page, Cynthia Cohen, Douglas Parker, Ron Yaar, Anya Li, A. Hestley, K. Delman, Douglas Murray, K. McMasters, Charles Balch, Stanley Leong (2008)
Regional Recurrence After Negative Sentinel Lymph Node Biopsy for Melanoma. DiscussionAnnals of Surgery, 248
Paul Davis, J. Serpell, J. Kelly, E. Paul (2011)
Axillary lymph node dissection for malignant melanomaANZ Journal of Surgery, 81
D. Damian, K. Shannon, R. Saw, J. Thompson (2009)
Topical diphencyprone immunotherapy for cutaneous metastatic melanomaAustralasian Journal of Dermatology, 50
S. Gibson, D. Byrne, A. Mckay (2004)
Ten‐year experience of carbon dioxide laser ablation as treatment for cutaneous recurrence of malignant melanomaBritish Journal of Surgery, 91
DG Coit, R Andtbacka, CK Bichakjian (2009)
MelanomaJ Natl Compr Cancer Netw, 7
T. Grotz, A. Mansfield, L. Kottschade, L. Erickson, C. Otley, S. Markovic, J. Jakub (2011)
In-transit melanoma: an individualized approach.Oncology, 25 14
MD SINGLETARY, PhD TUCKER, W. Andarthur, MD’ JR (1988)
Multivariate analysis of prognostic factors in regional cutaneous metastases of extremity melanomaCancer, 61
Grant Carlson, Andrew Page, Cynthia Cohen, Douglas Parker, Ron Yaar, Anya Li, A. Hestley, K. Delman, Douglas Murray (2008)
Regional Recurrence After Negative Sentinel Lymph Node Biopsy for MelanomaAnnals of Surgery, 248
B. Coventry, B. Chatterton, F. Whitehead, C. James, P. Gill (2004)
Sentinel lymph node dissection and lymphatic mapping for local subcutaneous recurrence in melanoma treatment: Longer-term follow-up resultsAnnals of Surgical Oncology, 11
H. Kaufman, Dae Kim, G. Deraffele, J. Mitcham, R. Coffin, S. Kim-Schulze (2010)
Local and Distant Immunity Induced by Intralesional Vaccination with an Oncolytic Herpes Virus Encoding GM-CSF in Patients with Stage IIIc and IV MelanomaAnnals of Surgical Oncology, 17
John Thompson, P. Hersey, E. Wachter (2008)
Chemoablation of metastatic melanoma using intralesional Rose BengalMelanoma Research, 18
N. Rao, H. Yu, A. Trotti, V. Sondak (2011)
The role of radiation therapy in the management of cutaneous melanoma.Surgical oncology clinics of North America, 20 1
B. Guadagnolo, G. Zagars (2009)
Adjuvant radiation therapy for high-risk nodal metastases from cutaneous melanoma.The Lancet. Oncology, 10 4
H. Kaufman, S. Bines (2010)
OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma.Future oncology, 6 6
B. Burmeister, M. Henderson, J. Ainslie, R. Fisher, J. Iulio, B. Smithers, A. Hong, K. Shannon, R. Scolyer, S. Carruthers, B. Coventry, S. Babington, J. Duprat, H. Hoekstra, J. Thompson (2012)
Adjuvant radiotherapy versus observation alone for patients at risk of lymph-node field relapse after therapeutic lymphadenectomy for melanoma: a randomised trial.The Lancet. Oncology, 13 6
A. Bedikian, J. Richards, D. Kharkevitch, M. Atkins, E. Whitman, R. Gonzalez (2010)
A phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanomaMelanoma Research, 20
K. Olivier, S. Schild, C. Morris, P. Brown, S. Markovic (2007)
A higher radiotherapy dose is associated with more durable palliation and longer survival in patients with metastatic melanomaCancer, 110
G. Stevens, M. McKay (2006)
Dispelling the myths surrounding radiotherapy for treatment of cutaneous melanoma.The Lancet. Oncology, 7 7
R. Valett (1964)
What is the rolePsyccritiques, 9
C. Karakousis, C. Balch, M. Urist, M. Ross, Thomas Smith, A. Bartolucci (2006)
Local recurrence in malignant melanoma: Long-term results of the multiinstitutional randomized surgical trialAnnals of Surgical Oncology, 3
G. Beasley, A. Caudle, R. Petersen, N. McMahon, J. Padussis, P. Mosca, J. Zager, S. Hochwald, S. Grobmyer, K. Delman, R. Andtbacka, R. Noyes, J. Kane, H. Seigler, S. Pruitt, M. Ross, D. Tyler (2009)
A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.Journal of the American College of Surgeons, 208 5
D. Green, M. Bodman-Smith, A. Dalgleish, Michael Fischer (2007)
Phase I/II study of topical imiquimod and intralesional interleukin‐2 in the treatment of accessible metastases in malignant melanomaBritish Journal of Dermatology, 156
H. Alexander, D. Fraker, D. Bartlett, S. Libutti, S. Steinberg, P. Soriano, T. Beresnev (2010)
Analysis of factors influencing outcome in patients with in-transit malignant melanoma undergoing isolated limb perfusion using modern treatment parameters.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28 1
N. Khan, Mohammad Khan, Alex Almasan, Arun Singh, R. Macklis (2011)
The evolving role of radiation therapy in the management of malignant melanoma.International journal of radiation oncology, biology, physics, 80 3
R. Siegel, D. Naishadham, A. Jemal (2013)
Cancer statistics, 2013CA: A Cancer Journal for Clinicians, 63
V. Florin, E. Desmedt, S. Vercambre-Darras, L. Mortier (2012)
Topical treatment of cutaneous metastases of malignant melanoma using combined imiquimod and 5-fluorouracilInvestigational New Drugs, 30
J. Doukas, Alain Rolland (2012)
Mechanisms of action underlying the immunotherapeutic activity of Allovectin in advanced melanomaCancer Gene Therapy, 19
C. Rossi, S. Pasquali, S. Mocellin, A. Vecchiato, L. Campana, P. Pilati, A. Zanon, D. Nitti (2010)
Long-Term Results of Melphalan-Based Isolated Limb Perfusion With or Without Low-Dose TNF for In-Transit Melanoma MetastasesAnnals of Surgical Oncology, 17
C. Balch, S. Soong, J. Gershenwald, J. Thompson, D. Reintgen, N. Cascinelli, M. Urist, K. McMasters, M. Ross, J. Kirkwood, M. Atkins, John Thompson, D. Coit, D. Byrd, Renee Desmond, Yuting Zhang, Ping-Yu Liu, G. Lyman, A. Morabito (2001)
Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 19 16
R. Sawh-Martinez, Bernard Salameh, B. Colebunders, L. Tom, Salem Samra, C. Truini, S. Ariyan, D. Narayan (2012)
Level I Sparing Radical Neck Dissections for Cutaneous Melanoma in the Lymphoscintigram EraAnnals of Plastic Surgery, 69
T. Pawlik, M. Ross, Marcella Johnson, C. Schacherer, Dana McClain, P. Mansfield, Jeffrey Lee, J. Cormier, J. Gershenwald (2004)
Predictors and Natural History of In-Transit Melanoma After Sentinel LymphadenectomyAnnals of Surgical Oncology, 12
M. Seegenschmiedt, L. Keilholz, A. Altendorf-Hofmann, Anna Urban, H. Schell, W. Hohenberger, R. Sauer (1999)
Palliative radiotherapy for recurrent and metastatic malignant melanoma: prognostic factors for tumor response and long-term outcome: a 20-year experience.International journal of radiation oncology, biology, physics, 44 3
Surgical resection is the mainstay of therapy for locoregional recurrence of melanoma and the best chance for long-term cure in patients with locoregional recurrence of melanoma. In addition to true local recurrence at the site of the primary lesion, locoregional relapse can occur as regional nodal disease or as satellite or in-transit metastases, which may be unresectable and can present significant treatment challenges. Options for unresectable locoregional recurrence include regional hyperthermic isolated limb perfusion or isolated limb infusion, topical therapies, intralesional injection therapies, laser ablation, radiation therapy, and systemic therapy. Given the risk of further relapse and the negative impact on prognosis and overall survival after locoregional recurrence of melanoma, most patients should be considered for aggressive locoregional therapy.
Current Oncology Reports – Springer Journals
Published: Aug 2, 2013
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