Virologica Sinica (2018) 33:456–458 www.virosin.org https://doi.org/10.1007/s12250-018-0049-7 www.springer.com/12250(0123456789().,-volV)(0123456789().,-volV) PERSPECTIVE 1 1 1 1 1 • • • • Yuyan Wang Ling Ding Qing Zhu Minfeng Shu Qiliang Cai Received: 27 July 2018 / Accepted: 24 August 2018 / Published online: 17 September 2018 Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2018 Alzheimer’s disease (AD), also known as Alzheimer’s, is a HSV co-infection was also observed in some cases. This chronic neurodegenerative disorder with hallmark amyloid study began by comparing the speciﬁc characteristics of plaques in brain tissue. The diseases commences slowly two distinct AD-associated phenotypes, namely, individu- and worsens over time (Sjogren et al. 1952). Although it als with preclinical AD, who were cognitively intact at the has been investigated for over six decades, the cause of AD time of death, and cognitively intact persons without neu- is still not completely understood. It was initially thought ropathology, who served as the healthy controls. They next to be caused by genetic heritability (autosomal mutation performed functional genomic analysis and found multiple leading to aggregation of b-amyloid and misfolded tau lines of evidence of preclinical AD network alterations proteins) or head injury. However, hundreds of drug trials consistent
Virologica Sinica – Springer Journals
Published: Sep 17, 2018
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