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- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Springer Science+Business Media, LLC
- Subject
- Engineering; Engineering Fluid Dynamics; Nanotechnology; Biophysics and Biological Physics; Biomedical Engineering
- ISSN
- 1387-2176
- eISSN
- 1572-8781
- DOI
- 10.1007/s10544-009-9350-4
- pmid
- 19806459
- Publisher site
- See Article on Publisher Site
Abstract
We present in this paper the implementation of an innovative three dimensional (3D) microfabrication technology coupled with numerical simulation to enhance the mass transport in 3D cell culture. The core of this microfabrication technology is a high-resolution projection micro stereolithography (PμSL) using a spatial light modulator as a dynamic mask which enables a parallel fabrication of highly complex 3D microstructures. In this work, a set of poly (ethylene glycol) microfabricated bioreactors are demonstrated with PμSL technology. We observed both experimentally and numerically the regulation of metabolism and the growth of yeast cells by controlling the density of micro-capillaries. Further development of these 3D microfabricated bioreactors is expected to provide artificially constructed tissues for clinical applications.
Journal
Biomedical Microdevices – Springer Journals
Published: Oct 6, 2009