We introduce flow optical projection tomography, an imaging technique capable of visualizing the vasculature of living specimens in 3-D. The method detects the movement of cells in the bloodstream and creates flow maps using a motion-analysis procedure. Then, flow maps obtained from projection taken at several angles are used to reconstruct sections of the circulatory system of the specimen. We therefore demonstrate an in vivo , 3-D optical imaging technique that, without the use of any labeling, is able to reconstruct and visualize the vascular network of transparent and weakly scattering living specimens.
Journal of Biomedical Optics – SPIE
Published: Oct 1, 2011
Keywords: biomechanics; biomedical optical imaging; cellular biophysics; haemodynamics; image reconstruction; medical image processing; optical tomography; optical tomography; vascular networks; label free
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