Characterization Of Benzoporphyrin Derivative, A New Photosensitizer

Characterization Of Benzoporphyrin Derivative, A New Photosensitizer Benzoporphyrin derivative (BPD), synthesized from protoporphyrin and involving the formation of Diels-Alder adducts, contains four components, mono and di-acid derivatives of either ring A or ring B fused porphyrins. These compounds have been isolated and tested individually as photosensitizers both in vitro and in vivo. All forms of BPD are potent photosensiters in vitro and have a strong absorption peak at about 690 nm. 3H-BPDs were tested for biodistribution in tumor bearing mice. Distribution appeared to be similar to distribution data published by others for dihematoporphyrin ethers, with the exception that levels in skin were lower for BPD. Extraction of 3H-BPD from tissue, followed by in vitro testing of extracts for photosensitizing activity, indicated that BPD is aTly degraded in vivo. When BPDs were compared to Photofrin II for causing skin photosensitivity following intravenous administration, it was found that monoacid derivatives caused photosensitivity at 3 hours but not after 24 hours. The diacid forms did not cause appreciable skin photosensitivity even at 3 hours. Photodynamic therapy of tumors in mice with BPD showed that these compounds had comparable efficacy to Photofrin II under the experimental conditions used here. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proceedings of SPIE SPIE

Characterization Of Benzoporphyrin Derivative, A New Photosensitizer

Loading next page...
 
/lp/spie/characterization-of-benzoporphyrin-derivative-a-new-photosensitizer-oey0B0l9NO
Publisher
SPIE
Copyright
COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
ISSN
0277-786X
eISSN
1996-756X
DOI
10.1117/12.960196
Publisher site
See Article on Publisher Site

Abstract

Benzoporphyrin derivative (BPD), synthesized from protoporphyrin and involving the formation of Diels-Alder adducts, contains four components, mono and di-acid derivatives of either ring A or ring B fused porphyrins. These compounds have been isolated and tested individually as photosensitizers both in vitro and in vivo. All forms of BPD are potent photosensiters in vitro and have a strong absorption peak at about 690 nm. 3H-BPDs were tested for biodistribution in tumor bearing mice. Distribution appeared to be similar to distribution data published by others for dihematoporphyrin ethers, with the exception that levels in skin were lower for BPD. Extraction of 3H-BPD from tissue, followed by in vitro testing of extracts for photosensitizing activity, indicated that BPD is aTly degraded in vivo. When BPDs were compared to Photofrin II for causing skin photosensitivity following intravenous administration, it was found that monoacid derivatives caused photosensitivity at 3 hours but not after 24 hours. The diacid forms did not cause appreciable skin photosensitivity even at 3 hours. Photodynamic therapy of tumors in mice with BPD showed that these compounds had comparable efficacy to Photofrin II under the experimental conditions used here.

Journal

Proceedings of SPIESPIE

Published: Mar 17, 1989

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off