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G. Juodzbalys, Marija Sapragonienė, A. Wennerberg, Tomas Baltrukonis (2007)
Titanium dental implant surface micromorphology optimization.The Journal of oral implantology, 33 4
L. Dunphy (2011)
Osteology guidelines for oral and maxillofacial regeneration: preclinical models for translational researchBDJ, 211
A. Rühling, T. Kocher, J. Kreusch, H. Plagmann (1994)
Treatment of subgingival implant surfaces with Teflon-coated sonic and ultrasonic scaler tips and various implant curettes. An in vitro study.Clinical oral implants research, 5 1
I. Atsuta, Y. Ayukawa, Ryosuke Kondo, Wakana Oshiro, Yuri Matsuura, A. Furuhashi, Y. Tsukiyama, K. Koyano (2016)
Soft tissue sealing around dental implants based on histological interpretation.Journal of prosthodontic research, 60 1
J. Wohlfahrt, A. Aass, H. Rønold, S. Lyngstadaas (2011)
Micro CT and human histological analysis of a peri-implant osseous defect grafted with porous titanium granules: a case report.The International journal of oral & maxillofacial implants, 26 1
F. Schwarz, A. Hegewald, Gordon John, Narja Sahm, J. Becker (2013)
Four-year follow-up of combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination.Journal of clinical periodontology, 40 10
Victoria Ntrouka, M. Hoogenkamp, E. Zaura, F. Weijden (2011)
The effect of chemotherapeutic agents on titanium-adherent biofilms.Clinical oral implants research, 22 11
Diane Daubert, Bradley Weinstein, S. Bordin, B. Leroux, Thomas Flemming (2015)
Prevalence and predictive factors for peri-implant disease and implant failure: a cross-sectional analysis.Journal of periodontology, 86 3
Anton Wetzel, J. Vlassis, R. Caffesse, C. Hämmerle, Niklaus Lang (1999)
Attempts to obtain re-osseointegration following experimental peri-implantitis in dogs.Clinical oral implants research, 10 2
F. Schwarz, Narja Sahm, I. Mihatovic, V. Golubović, J. Becker (2011)
Surgical therapy of advanced ligature-induced peri-implantitis defects: cone-beam computed tomographic and histological analysis.Journal of clinical periodontology, 38 10
Michael Augthun, Joachim Tinschert, and Huber (1998)
In vitro studies on the effect of cleaning methods on different implant surfaces.Journal of periodontology, 69 8
S. Toma, C. Behets, M. Brecx, J. Lasserre (2018)
In Vitro Comparison of the Efficacy of Peri-Implantitis Treatments on the Removal and Recolonization of Streptococcus gordonii Biofilm on Titanium DisksMaterials, 11
K. Subramani, D. Wismeijer (2012)
Decontamination of titanium implant surface and re-osseointegration to treat peri-implantitis: a literature review.The International journal of oral & maxillofacial implants, 27 5
Merve Benli, C. Petit, H. Tenenbaum, O. Huck (2019)
In vitro Assessment of Peri-implantitis Treatment Procedures: A ReviewThe Open Dentistry Journal
Z. Cai, Yijun Li, Yanhuang Wang, Shuai Chen, Shan Jiang, Huan Ge, Lishan Lei, Xiaojing Huang (2019)
Disinfect Porphyromonas gingivalis Biofilm on Titanium Surface with Combined Application of Chlorhexidine and Antimicrobial Photodynamic TherapyPhotochemistry and Photobiology, 95
M. Shie, Wen-Ching Chang, Li-Ju Wei, Yu-Hsin Huang, Chien-Han Chen, C. Shih, Yi-Wen Chen, Yu-Fang Shen (2017)
3D Printing of Cytocompatible Water-Based Light-Cured Polyurethane with Hyaluronic Acid for Cartilage Tissue Engineering ApplicationsMaterials, 10
F. Schwarz, Pascal Papanicolau, D. Rothamel, B. Beck, M. Herten, J. Becker (2006)
Influence of plaque biofilm removal on reestablishment of the biocompatibility of contaminated titanium surfaces.Journal of biomedical materials research. Part A, 77 3
C. Tastepe, Xingnan Lin, M. Donnet, B. Doulabi, D. Wismeijer, Y. Liu (2018)
Re-establishment of Biocompatibility of the In Vitro Contaminated Titanium Surface Using Osteoconductive Powders With Air-Abrasive Treatment.The Journal of oral implantology, 44 2
Sungtae Kim, K. Hu, U. Jung (2018)
Reosseointegration After Regenerative Surgical Therapy Using a Synthetic Bone Substitute for Peri-implantitis: Human Autopsy Study.The International journal of periodontics & restorative dentistry, 38 4
V. Stuani, D. Kim, Masazumi Nagai, Chia-Yu Chen, Adriana Sant'Ana (2020)
Effectiveness and surface changes of different decontamination protocols at smooth and minimally rough titanium surfaces.Journal of periodontology
S. Renvert, I. Polyzois, R. Maguire (2009)
Re-osseointegration on previously contaminated surfaces: a systematic review.Clinical oral implants research, 20 Suppl 4
P. Fletcher, Daniel Deluiz, Eduardo Tinoco, J. Ricci, D. Tarnow, J. Tinoco (2017)
Human Histologic Evidence of Reosseointegration Around an Implant Affected with Peri-implantitis Following Decontamination with Sterile Saline and Antiseptics: A Case History Report.The International journal of periodontics & restorative dentistry, 37 4
Jason Wandiyanto, V. Truong, M. Kobaisi, S. Juodkazis, H. Thissen, O. Bazaka, K. Bazaka, R. Crawford, E. Ivanova (2019)
The Fate of Osteoblast-Like MG-63 Cells on Pre-Infected Bactericidal Nanostructured Titanium SurfacesMaterials, 12
R. Smeets, A. Henningsen, Ole Jung, M. Heiland, Christian Hammächer, J. Stein (2014)
Definition, etiology, prevention and treatment of peri-implantitis – a reviewHead & Face Medicine, 10
A. Homiak, P. Cook, J. Deboer (1992)
Effect of hygiene instrumentation on titanium abutments: a scanning electron microscopy study.The Journal of prosthetic dentistry, 67 3
L. Persson, M. Araújo, T. Berglundh, Kerstin Gröndahl, J. Lindhe (1999)
Resolution of peri-implantitis following treatment. An experimental study in the dog.Clinical oral implants research, 10 3
G. Kotsakis, Caixia Lan, J. Barbosa, K. Lill, Ruoqiong Chen, J. Rudney, C. Aparicio (2016)
Antimicrobial Agents Used in the Treatment of Peri-Implantitis Alter the Physicochemistry and Cytocompatibility of Titanium Surfaces.Journal of periodontology, 87 7
P. Valderrama, Jonathan Blansett, M. González, Myrna Cantu, T. Wilson (2014)
Detoxification of Implant Surfaces Affected by Peri-Implant Disease: An Overview of Non-surgical MethodsThe Open Dentistry Journal, 8
L. Sennerby, L. Persson, T. Berglundh, A. Wennerberg, J. Lindhe (2005)
Implant stability during initiation and resolution of experimental periimplantitis: an experimental study in the dog.Clinical implant dentistry and related research, 7 3
R. Mengel, C. Buns, C. Mengel, L. Flores-de-Jacoby (1998)
An in vitro study of the treatment of implant surfaces with different instruments.The International journal of oral & maxillofacial implants, 13 1
(2017)
Prevalences of periimplantitis and peri-implant mucositis: systematic review and meta-analysis
A. Kozlovsky, Z. Artzi, O. Moses, N. Kamin-belsky, R. Greenstein (2006)
Interaction of chlorhexidine with smooth and rough types of titanium surfaces.Journal of periodontology, 77 7
L. Persson, J. Mouhyi, T. Berglundh, L. Sennerby, J. Lindhe (2004)
Carbon dioxide laser and hydrogen peroxide conditioning in the treatment of periimplantitis: an experimental study in the dog.Clinical implant dentistry and related research, 6 4
D. Busenlechner, R. Fürhauser, R. Haas, G. Watzek, G. Mailath, B. Pommer (2014)
Long-term implant success at the Academy for Oral Implantology: 8-year follow-up and risk factor analysisJournal of Periodontal & Implant Science, 44
S. Froum, P. Rosen (2014)
Reentry evaluation following treatment of peri-implantitis with a regenerative approach.The International journal of periodontics & restorative dentistry, 34 1
M. Esposito, H. Worthington, P. Thomsen, P. Coulthard (2003)
Interventions for replacing missing teeth: different types of dental implants.The Cochrane database of systematic reviews, 3
M. Madi, M. Htet, Osama Zakaria, A. Alagl, S. Kasugai (2018)
Re-osseointegration of Dental Implants After Periimplantitis Treatments: A Systematic ReviewImplant Dentistry, 27
Mohamed Alhag, S. Renvert, I. Polyzois, N. Claffey (2008)
Re-osseointegration on rough implant surfaces previously coated with bacterial biofilm: an experimental study in the dog.Clinical oral implants research, 19 2
M. Esposito, M. Grusovin, H. Worthington (2012)
Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review.European journal of oral implantology, 5 Suppl
Vitor Stuani, Gustavo Manfredi, Vitor Kondo, P. Noritomi, P. Lisboa-Filho, Adriana Sant’Ana (2020)
The use of additively manufactured scaffolds for treating gingival recession associated with interproximal defects, 4
(2016)
Increasing prevalence of peri-implantitis: How will we manage
Marco Giannelli, F. Chellini, M. Margheri, Paolo Tonelli, A. Tani (2008)
Effect of chlorhexidine digluconate on different cell types: a molecular and ultrastructural investigation.Toxicology in vitro : an international journal published in association with BIBRA, 22 2
Å. Leonhardt, S. Renvert, G. Dahlén (1999)
Microbial findings at failing implants.Clinical oral implants research, 10 5
In vitro evaluations are essential to gaining a better understanding of re-osseointegration, while reducing animal use and the overall costs of peri-implantitis studies. This pilot study evaluated preosteoblast migration from 3-D-printed scaffolds to decontaminated titanium microimplants, creating a system that tries to mimic the bone–implant interface. Smooth (S) and minimally rough (R) titanium microimplants were incubated in Escherichia coli cultures and divided into six groups according to the decontamination protocol applied: EDTA gel (EDTA); chlorhexidine (CHL); chlorhexidine-soaked gauze (GCHL); scaling (SC); titanium brush (TiB); and implantoplasty (IP). Pristine S and R microimplants were used as the controls (C). After the decontamination procedures, the microimplants were inserted in 3-D-printed polyurethane-based scaffolds previously inoculated with preosteoblast cell cultures. Cellular migration was assessed after 24, 72 and 120 hours by ATP quantification. At the 120-hour time point, there was no statistically significant difference between S-C, S-EDTA, S-CHL, S-GCHL and S-SC (p > 0.05), and between R-C, R-EDTA and R-GCHL (p > 0.05). The in vitro model developed in this pilot study successfully demonstrated cell migration on the different decontaminated surfaces. This methodology suggests that on smooth microimplants, EDTA, GCHL, SC and TiB decontamination may have a reduced impact on preosteoblast migration, while on minimally rough microimplants, EDTA and GCHL decontamination affected cell migration the least. However, when selecting a decontamination protocol, the effectiveness of the decontamination per se must also be considered.
Alternatives to Laboratory Animals – SAGE
Published: May 1, 2021
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