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Recent Advances in the Synthesis of the Carbocyclic Nucleosides as Potential Antiviral Agents:

Recent Advances in the Synthesis of the Carbocyclic Nucleosides as Potential Antiviral Agents: Compared with 4′-oxonucleosides, there have been far fewer systematic structure-activity relationship studies on carbocyclic nucleosides as antiviral and antitumour agents. This is mainly because of the synthetic problems in preparing the carbasugars. However, the recent discovery of the ring-closing metathesis (RCM) (a powerful tool for the preparation of 5-membered carbasugar via C-C bond formation) has made it possible to synthesize the key carbasugars to a preparative scale. This review summarizes the asymmetric syntheses of carbasugars and carbocyclic nucleosides, using an RCM reaction as a key step. Furthermore, the review includes valuable information for designing and synthesizing novel carbocyclic nucleosides. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Antiviral Chemistry and Chemotherapy SAGE

Recent Advances in the Synthesis of the Carbocyclic Nucleosides as Potential Antiviral Agents:

Antiviral Chemistry and Chemotherapy , Volume 15 (5): 16 – Jun 23, 2016

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Publisher
SAGE
Copyright
Copyright © 2019 by SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
ISSN
2040-2066
eISSN
2040-2066
DOI
10.1177/095632020401500502
Publisher site
See Article on Publisher Site

Abstract

Compared with 4′-oxonucleosides, there have been far fewer systematic structure-activity relationship studies on carbocyclic nucleosides as antiviral and antitumour agents. This is mainly because of the synthetic problems in preparing the carbasugars. However, the recent discovery of the ring-closing metathesis (RCM) (a powerful tool for the preparation of 5-membered carbasugar via C-C bond formation) has made it possible to synthesize the key carbasugars to a preparative scale. This review summarizes the asymmetric syntheses of carbasugars and carbocyclic nucleosides, using an RCM reaction as a key step. Furthermore, the review includes valuable information for designing and synthesizing novel carbocyclic nucleosides.

Journal

Antiviral Chemistry and ChemotherapySAGE

Published: Jun 23, 2016

Keywords: carbocyclic nucleosides,ring-closing metathesis (RCM),asymmetric synthesis,antiviral,carbasugars

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