Letter Annals of Clinical Biochemistry 0(0) 1–2 journals.sagepub.com/home/acb Table 1. Effect of increasing concentrations of spiked Potential interference in the Abbott 19-norethindrone on serum total testosterone. Architect 2nd generation total Measured testosterone concentration (nmol/L) testosterone assay No 10 nmol/L 50 nmol/L 100 nmol/L Dear Editor, Sample spike spike spike spike We have occasionally observed signiﬁcantly elevated serum total testosterone concentrations in female Serum pool 0.7 1.4 3.4 5.7 patient samples using the Abbott Architect 2nd gener- Patient 1 1.9 2.6 4.4 6.7 ation total testosterone assay which have not been con- Patient 2 1.5 2.1 3.4 5.3 ﬁrmed by mass spectrometry, suggesting the possibility Patient 3 1.6 1.8 3.8 5.9 of interference. Patient 4 1.2 1.7 4.3 7.1 17a-Ethynyl-19-nortestosterone, commonly known Patient 5 1.0 1.2 3.3 5.8 as norethisterone (also as 19-norethisterone, norethin- Patient 6 1.3 2.2 4.5 7.6 drone and 19-norethindrone), and a structurally similar Patient 7 0.7 1.3 3.9 6.6 compound, norethisterone acetate, are steroidal com- Patient 8 0.8 1.5 3.5 5.8 pounds of the progestogen drug class found in the Patient 9 1.2 1.9 4.9 6.0 combined oral contraceptive pill and other forms of contraceptive, e.g. progestogen-only pill. These com- pounds share the same steroid backbone
Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine – SAGE
Published: Jan 1, 2018
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