Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient with Prior Thymoma and Aplastic Anemia:

Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient... We report the case of a 37-year old man presenting with a left ventricular cardiac thrombus in the setting of subclinical paroxysmal nocturnal hemoglobinura (PNH) developing two years after immunosuppressive therapy for thymoma-associated aplastic anemia. The literature regarding the interplay between autoimmunity and immunosuppression, aplastic anemia, thymoma and the emergence of PNH is reviewed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Medicine Insights: Oncology SAGE

Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient with Prior Thymoma and Aplastic Anemia:

Download PDF

Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient with Prior Thymoma and Aplastic Anemia:

Migdady, Yazan; Olszewski, Adam J.
Clinical Medicine Insights: Oncology , Volume 5: 1 – Nov 3, 2011

Abstract

We report the case of a 37-year old man presenting with a left ventricular cardiac thrombus in the setting of subclinical paroxysmal nocturnal hemoglobinura (PNH) developing two years after immunosuppressive therapy for thymoma-associated aplastic anemia. The literature regarding the interplay between autoimmunity and immunosuppression, aplastic anemia, thymoma and the emergence of PNH is reviewed.

Loading next page...
 
/lp/sage/paroxysmal-nocturnal-hemoglobinuria-presenting-with-a-left-mz9e08d01F
Publisher
SAGE
Copyright
Copyright © 2022 by SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
eISSN
1179-5549
DOI
10.4137/cmo.s8442
Publisher site
See Article on Publisher Site

Abstract

We report the case of a 37-year old man presenting with a left ventricular cardiac thrombus in the setting of subclinical paroxysmal nocturnal hemoglobinura (PNH) developing two years after immunosuppressive therapy for thymoma-associated aplastic anemia. The literature regarding the interplay between autoimmunity and immunosuppression, aplastic anemia, thymoma and the emergence of PNH is reviewed.

Journal

Clinical Medicine Insights: Oncology – SAGE

Published: Nov 3, 2011

Keywords: paroxysmal nocturnal hemoglobinuria; cardiac thrombosis; thymoma; aplastic anemia

References

  • Clinical manifestations of paroxysmal nocturnal hemoglobinuria: present state and future problems.
  • Thrombosis in patients with paroxysmal nocturnal hemoglobinuria.
  • The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease.
  • Left apical pedunculated thrombus with normal ventricular function mimicking an intracardiac tumor.
  • Cerebral ischemic infarction in paroxysmal nocturnal hemoglobinuria report of 2 cases and updated review of 7 previously published patients.
  • Thrombosis in paroxysmal nocturnal hemoglobinuria: sites, risks, outcome. An overview.
  • Activated platelets in paroxysmal nocturnal haemoglobinuria.
  • Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia.
  • Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria.
  • Late clonal complications in severe aplastic anemia.
  • Paroxysmal nocturnal haemoglobinuria: a replacement of haematopoietic tissue?
  • Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.
  • Thymoma followed by paroxysmal nocturnal hemoglobinuria: A unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes.
  • Management of paroxysmal nocturnal haemoglobinuria: a personal view.
  • Diagnosis and management of paroxysmal nocturnal hemoglobinuria.
  • Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia.
  • Primary prophylaxis with warfarin prevents thrombosis in paroxysmal nocturnal hemoglobinuria (PNH).
  • Cardiopulmonary bypass surgery in a patient with paroxysmal nocturnal haemoglobinuria.
  • Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria.
  • Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival.