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Norovirus disease among older adults

Norovirus disease among older adults Norovirus, a leading cause of gastroenteritis outbreaks worldwide, results in substantial direct and indirect healthcare costs. Adults older than 65 years of age bear a significant proportion of the disease burden, and the disease course in this population is often more severe and protracted. In this narrative review, we discuss the epidemiology of norovirus infection, mechanisms of pathogenesis, and transmission pertinent to outbreaks along with infection prevention and control efforts. We also describe the clinical manifestations of norovirus disease with a focus on individuals older than 65 years of age, diagnosis and available treatment options, and the challenges and progress within vaccine development. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Therapeutic Advances in Infectious Disease SAGE

Norovirus disease among older adults

Norovirus disease among older adults

Therapeutic Advances in Infectious Disease , Volume 9: 1 – Nov 1, 2022

Abstract

Norovirus, a leading cause of gastroenteritis outbreaks worldwide, results in substantial direct and indirect healthcare costs. Adults older than 65 years of age bear a significant proportion of the disease burden, and the disease course in this population is often more severe and protracted. In this narrative review, we discuss the epidemiology of norovirus infection, mechanisms of pathogenesis, and transmission pertinent to outbreaks along with infection prevention and control efforts. We also describe the clinical manifestations of norovirus disease with a focus on individuals older than 65 years of age, diagnosis and available treatment options, and the challenges and progress within vaccine development.

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Publisher
SAGE
Copyright
© The Author(s), 2022
ISSN
2049-9361
eISSN
2049-937X
DOI
10.1177/20499361221136760
Publisher site
See Article on Publisher Site

Abstract

Norovirus, a leading cause of gastroenteritis outbreaks worldwide, results in substantial direct and indirect healthcare costs. Adults older than 65 years of age bear a significant proportion of the disease burden, and the disease course in this population is often more severe and protracted. In this narrative review, we discuss the epidemiology of norovirus infection, mechanisms of pathogenesis, and transmission pertinent to outbreaks along with infection prevention and control efforts. We also describe the clinical manifestations of norovirus disease with a focus on individuals older than 65 years of age, diagnosis and available treatment options, and the challenges and progress within vaccine development.

Journal

Therapeutic Advances in Infectious DiseaseSAGE

Published: Nov 1, 2022

Keywords: norovirus; older adults

References