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Non-Nucleoside Reverse Transcriptase Inhibitors: The NNRTI Boom:

Non-Nucleoside Reverse Transcriptase Inhibitors: The NNRTI Boom: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drugs for the treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside reverse transcriptase (RT) inhibitors and protease inhibitors. The first generation of NNRTIs have, however, suffered from the rapid development of resistance. This review discusses the properties of the FDA-approved NNRTI drugs and focuses on the recent efforts being made to produce second generation inhibitors that circumvent this resistance problem. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Antiviral Chemistry and Chemotherapy SAGE

Non-Nucleoside Reverse Transcriptase Inhibitors: The NNRTI Boom:

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Publisher
SAGE
Copyright
Copyright © 2019 by SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
ISSN
2040-2066
eISSN
2040-2066
DOI
10.1177/095632029901000601
Publisher site
See Article on Publisher Site

Abstract

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drugs for the treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside reverse transcriptase (RT) inhibitors and protease inhibitors. The first generation of NNRTIs have, however, suffered from the rapid development of resistance. This review discusses the properties of the FDA-approved NNRTI drugs and focuses on the recent efforts being made to produce second generation inhibitors that circumvent this resistance problem.

Journal

Antiviral Chemistry and ChemotherapySAGE

Published: Jun 24, 2016

Keywords: HIV-1,non-nucleoside reverse transcriptase inhibitors,HEPT,nevirapine,delavirdine,efavirenz,trovirdine

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