Kynurenine potentiates the DOI head shake in mice

Kynurenine potentiates the DOI head shake in mice Kynurenine potentiates the DOI head shake in mice SAGE Publications, Inc.1995DOI: 10.1177/026988119500900112 Andrew C. McCreary Pharmaceutical Sciences Institute, Aston University, Birmingham B4 7ET, UK Sheila L. Handley Pharmaceutical Sciences Institute, Aston University, Birmingham B4 7ET, UK kynurenine DOI head shake mice case report Kynurenine is the first stable metabolite of the kynurenine pathway [which metabolises > 9007o of body tryptophan (Wolf, 1974) ]. A number of kynurenine pathway metabolites are known to have biological activity, including 3-hydroxykynurenine, xanthurenic acid, quinolinic acid and kynurenic acid (for reviews, see Schwarcz, 1993; Heyes, 1993; Stone and Connick, 1985). Recent studies have demonstrated that plasma kynurenine concentrations were elevated in all of seven patients suffering from Gilles de la Tourette's Syndrome (GTS), a disease characterised by motor and vocal tics (Dursun et al., 1994). It has been suggested that tic-like movements such as head shakes, which occur in rodents after a wide variety of pharmacological challenges, may model the tics observed in GTS (Handley and Dursun, 1992). In mice, systemic administration of kynurenine and its metabolite 3-hydroxykynurenine potentiated the head shakes induced by centrally administered 5-hydroxytryptamine (5-HT) or systemic L-5-hydroxytryptophan (5-HTP) (Handley and Miskin, 1977). 5-HT-related head shakes are thought to be http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Psychopharmacology SAGE

Kynurenine potentiates the DOI head shake in mice

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Kynurenine potentiates the DOI head shake in mice

Abstract

Kynurenine potentiates the DOI head shake in mice SAGE Publications, Inc.1995DOI: 10.1177/026988119500900112 Andrew C. McCreary Pharmaceutical Sciences Institute, Aston University, Birmingham B4 7ET, UK Sheila L. Handley Pharmaceutical Sciences Institute, Aston University, Birmingham B4 7ET, UK kynurenine DOI head shake mice case report Kynurenine is the first stable metabolite of the kynurenine pathway [which metabolises > 9007o of body tryptophan (Wolf, 1974) ]. A number of kynurenine pathway metabolites are known to have biological activity, including 3-hydroxykynurenine, xanthurenic acid, quinolinic acid and kynurenic acid (for reviews, see Schwarcz, 1993; Heyes, 1993; Stone and Connick, 1985). Recent studies have demonstrated that plasma kynurenine concentrations were elevated in all of seven patients suffering from Gilles de la Tourette's Syndrome (GTS), a disease characterised by motor and vocal tics (Dursun et al., 1994). It has been suggested that tic-like movements such as head shakes, which occur in rodents after a wide variety of pharmacological challenges, may model the tics observed in GTS (Handley and Dursun, 1992). In mice, systemic administration of kynurenine and its metabolite 3-hydroxykynurenine potentiated the head shakes induced by centrally administered 5-hydroxytryptamine (5-HT) or systemic L-5-hydroxytryptophan (5-HTP) (Handley and Miskin, 1977). 5-HT-related head shakes are thought to be
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Publisher
SAGE
Copyright
Copyright © 1995 by SAGE Publications
ISSN
0269-8811
eISSN
0269-8811
D.O.I.
10.1177/026988119500900112
Publisher site
See Article on Publisher Site

Abstract

Kynurenine potentiates the DOI head shake in mice SAGE Publications, Inc.1995DOI: 10.1177/026988119500900112 Andrew C. McCreary Pharmaceutical Sciences Institute, Aston University, Birmingham B4 7ET, UK Sheila L. Handley Pharmaceutical Sciences Institute, Aston University, Birmingham B4 7ET, UK kynurenine DOI head shake mice case report Kynurenine is the first stable metabolite of the kynurenine pathway [which metabolises > 9007o of body tryptophan (Wolf, 1974) ]. A number of kynurenine pathway metabolites are known to have biological activity, including 3-hydroxykynurenine, xanthurenic acid, quinolinic acid and kynurenic acid (for reviews, see Schwarcz, 1993; Heyes, 1993; Stone and Connick, 1985). Recent studies have demonstrated that plasma kynurenine concentrations were elevated in all of seven patients suffering from Gilles de la Tourette's Syndrome (GTS), a disease characterised by motor and vocal tics (Dursun et al., 1994). It has been suggested that tic-like movements such as head shakes, which occur in rodents after a wide variety of pharmacological challenges, may model the tics observed in GTS (Handley and Dursun, 1992). In mice, systemic administration of kynurenine and its metabolite 3-hydroxykynurenine potentiated the head shakes induced by centrally administered 5-hydroxytryptamine (5-HT) or systemic L-5-hydroxytryptophan (5-HTP) (Handley and Miskin, 1977). 5-HT-related head shakes are thought to be

Journal

Journal of PsychopharmacologySAGE

Published: Jan 1, 1995

Keywords: kynurenine; DOI; head shake; mice; case report;

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