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1 To evaluate in vitro inhibitory effects of four types of histamine H2 - receptor antagonist ( H2 - receptor antagonists ), famotidine, roxatidine, cimetidine and ranitidine, on platelet function , we ...
1 The inhibitory effects of three prostanoid analogues, EP 045, EP 092 and pinane thromboxane A2 (PTA2), on the aggregation of human platelets in vitro have been investigated. 2 In diluted platelet ...
, P2Y12 receptor antagonists have the potential to have dramatic inhibitory effects on platelet function , regardless of the activating stimuli. As discussed, ticlopidine and clopidogrel represent the first ...
. Aldosterone antagonists were shown to reduce morbidity and mortality in patients with heart failure and to and this effect could be at least in part mediated by an improvement in endothelial function ...
Tirofiban Tirofiban is a non-peptide GPIIb/IIIa receptor antagonist that also serves as an effective anti- platelet agent by inhibiting the binding of fibrinogen to the activated GPIIb/IIIa receptor complex ...
. However, it remains unknown whether altering therapy based on platelet function tests is beneficial to patients. Platelets , Drug resistance, Aspirin, Clopidogrel, Thienopyridines, GPIIb–IIIa antagonists ...
therapy had failed). Thus, although aspirin is an extremely cost- effective platelet antagonist , it is often not fully effective in the prevention or treatment of ACS. Gp IIb/IIIa Inhibitors As the integral ...
, targeting receptors with agonist or antagonist drugs could have a wide range of effects in cells and tissues including potential untoward side effects . Therefore, it is possible that using drugs that elevate ...
TXA2synthase inhibitor or TXA2receptor (thromboxane-prostanoid [TP] receptor ) antagonist blocks the action of TXA2, and because these drugs are widely used in the clinical arena without major adverse effects ...
are important for therapeutic effect . It is also suggested that the interaction of IVIG with the inhibitory receptor FcγRIIB is insufficient for effective amelioration of ITP and that, at least in this model ...
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