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Inhibition of Ganciclovir-Resistant Human Cytomegalovirus Replication by Kampo (Japanese Herbal Medicine):

Inhibition of Ganciclovir-Resistant Human Cytomegalovirus Replication by Kampo (Japanese Herbal... We examined the effect of Kampo on the replication of ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) in the human embryonic fibroblast cell line MRC-5. Treatment of HCMV-infected cells with Sho-seiryu-to (SST; Xiao-Qing-Long-Tang in Chinese) resulted in the inhibition of viral replication without affecting the cell growth. SST treatment decreased the synthesis of viral DNA, but had no virucidal effect on cell-free HCMV. However, the inhibitory effect of SST on HCMV replication was ablated by anti-interferon-β (IFN-β) antibody suggesting that SST inhibits the replication of GCV-resistant HCMV through the induction of IFN-β. These results suggest that SST is a novel compund with potential as an anti-HCMV. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Antiviral Chemistry and Chemotherapy SAGE

Inhibition of Ganciclovir-Resistant Human Cytomegalovirus Replication by Kampo (Japanese Herbal Medicine):

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Publisher
SAGE
Copyright
Copyright © 2019 by SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
ISSN
2040-2066
eISSN
2040-2066
DOI
10.1177/095632020601700102
Publisher site
See Article on Publisher Site

Abstract

We examined the effect of Kampo on the replication of ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) in the human embryonic fibroblast cell line MRC-5. Treatment of HCMV-infected cells with Sho-seiryu-to (SST; Xiao-Qing-Long-Tang in Chinese) resulted in the inhibition of viral replication without affecting the cell growth. SST treatment decreased the synthesis of viral DNA, but had no virucidal effect on cell-free HCMV. However, the inhibitory effect of SST on HCMV replication was ablated by anti-interferon-β (IFN-β) antibody suggesting that SST inhibits the replication of GCV-resistant HCMV through the induction of IFN-β. These results suggest that SST is a novel compund with potential as an anti-HCMV.

Journal

Antiviral Chemistry and ChemotherapySAGE

Published: Jun 22, 2016

Keywords: cytomegalovirus,ganciclovir,Kampo medicine,interferon-β

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