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Frailty and Quality of Life for People With Alzheimer’s Dementia and Mild Cognitive Impairment:

Frailty and Quality of Life for People With Alzheimer’s Dementia and Mild Cognitive Impairment: Background: Our aim was to investigate the relationship between frailty and health-related quality of life (HR-QOL) in cognitively impaired elderly individuals. Methods: A cross-sectional observational study of a convenience sample of 115 patients with a diagnosis of Alzheimer’s dementia or mild cognitive impairment. Frailty was measured using the biological syndrome model and HR-QOL was measured using the DEMQOL-Proxy. Regression models were constructed to establish the factors associated with HR-QOL. Results: Frailty and neuropsychiatric symptoms were associated with HR-QOL, with Mini-Mental State Examination (MMSE) scores ≥21 (P = .037, P ≤ .001, and R2 = .362). Functional limitation was associated with HR-QOL, with MMSE scores ≤20 (P = .017 and R2 = .377). Conclusion: Frailty and neuropsychiatric symptoms were the determinants of HR-QOL in the earlier stages of cognitive impairment. Functional limitation predicted HR-QOL in the later stages of cognitive impairment. Frailty may represent a novel modifiable target in early dementia to improve HR-QOL for patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Alzheimer's Disease & Other Dementias SAGE

Frailty and Quality of Life for People With Alzheimer’s Dementia and Mild Cognitive Impairment:

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References (48)

Publisher
SAGE
Copyright
Copyright © 2019 by Sage Publications
ISSN
1533-3175
eISSN
1938-2731
DOI
10.1177/1533317511435661
pmid
22467414
Publisher site
See Article on Publisher Site

Abstract

Background: Our aim was to investigate the relationship between frailty and health-related quality of life (HR-QOL) in cognitively impaired elderly individuals. Methods: A cross-sectional observational study of a convenience sample of 115 patients with a diagnosis of Alzheimer’s dementia or mild cognitive impairment. Frailty was measured using the biological syndrome model and HR-QOL was measured using the DEMQOL-Proxy. Regression models were constructed to establish the factors associated with HR-QOL. Results: Frailty and neuropsychiatric symptoms were associated with HR-QOL, with Mini-Mental State Examination (MMSE) scores ≥21 (P = .037, P ≤ .001, and R2 = .362). Functional limitation was associated with HR-QOL, with MMSE scores ≤20 (P = .017 and R2 = .377). Conclusion: Frailty and neuropsychiatric symptoms were the determinants of HR-QOL in the earlier stages of cognitive impairment. Functional limitation predicted HR-QOL in the later stages of cognitive impairment. Frailty may represent a novel modifiable target in early dementia to improve HR-QOL for patients.

Journal

American Journal of Alzheimer's Disease & Other Dementias – SAGE

Published: Mar 30, 2012

Keywords: frailty,quality of life,Alzheimer’s disease,mild cognitive impairment

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