Access the full text.
Sign up today, get DeepDyve free for 14 days.
S. Giles, C. Messiou, D. Collins, V. Morgan, C. Simpkin, S. West, F. Davies, G. Morgan, N. deSouza (2014)
Whole-body diffusion-weighted MR imaging for assessment of treatment response in myeloma.Radiology, 271 3
A Baur-Melnyk, S Buhmann, C Becker (2008)
Whole-body MRI versus whole-body MDCT for staging of multiple myelomaAJR Am J Roentgenol, 190
J. Hillengass, T. Bäuerle, R. Bartl, M. Andrulis, F. McClanahan, F. Laun, C. Zechmann, Rajiv Shah, Barbara Wagner-Gund, D. Simon, C. Heiss, K. Neben, A. Ho, H. Schlemmer, H. Goldschmidt, S. Delorme, B. Stieltjes (2011)
Diffusion‐weighted imaging for non‐invasive and quantitative monitoring of bone marrow infiltration in patients with monoclonal plasma cell disease: a comparative study with histologyBritish Journal of Haematology, 153
T. Gleeson, T. Gleeson, J. Moriarty, C. Shortt, James Gleeson, Patricia Fitzpatrick, Brenda Byrne, Johnny McHugh, Martin O'Connell, Peter O'Gorman, Steven Eustace (2009)
Accuracy of whole-body low-dose multidetector CT (WBLDCT) versus skeletal survey in the detection of myelomatous lesions, and correlation of disease distribution with whole-body MRI (WBMRI)Skeletal Radiology, 38
D. Kazandjian (2016)
Multiple myeloma epidemiology and survival: A unique malignancy.Seminars in oncology, 43 6
P. Kröpil, R. Fenk, L. Fritz, D. Blondin, G. Kobbe, U. Mödder, M. Cohnen (2007)
Comparison of whole-body 64-slice multidetector computed tomography and conventional radiography in staging of multiple myelomaEuropean Radiology, 18
D. Albano, L. Grutta, E. Grassedonio, C. Patti, R. Lagalla, M. Midiri, M. Galia (2016)
Pitfalls in whole body MRI with diffusion weighted imaging performed on patients with lymphoma: What radiologists should know.Magnetic resonance imaging, 34 7
MA Dimopoulos, J Hillengass, S Usmani (2015)
Role of magnetic resonance imaging in the management of patients with multiple myeloma: a consensus statementJ Clin Oncol, 33
Y. Maeder, V. Dunet, Raphael Richard, F. Becce, P. Omoumi (2017)
Bone Marrow Metastases: T2-weighted Dixon Spin-Echo Fat Images Can Replace T1-weighted Spin-Echo Images.Radiology, 286 3
SV Rajkumar, MA Dimopoulos, A Palumbo (2014)
International Myeloma Working Group updated criteria for the diagnosis of multiple myelomaLancet Oncol, 15
J Hillengass, LA Moulopoulos, S Delorme (2016)
Findings of whole body computed tomography compared to conventional skeletal survey in patients with monoclonal plasma cell disorders - a study of the International Myeloma Working GroupBlood, 128
C. Messiou, M. Kaiser (2015)
Whole body diffusion weighted MRI – a new view of myelomaBritish Journal of Haematology, 171
K. Fechtner, J. Hillengass, S. Delorme, C. Heiss, K. Neben, H. Goldschmidt, H. Kauczor, M. Weber (2010)
Staging monoclonal plasma cell disease: comparison of the Durie-Salmon and the Durie-Salmon PLUS staging systems.Radiology, 257 1
FE Lecouvet, D Geukens, A Stainier (2007)
Magnetic resonance imaging of the axial skeleton for detecting bone metastases in patients with high-risk prostate cancer: diagnostic and cost-effectiveness and comparison with current detection strategiesJ Clin Oncol, 25
A. Kosmala, A. Weng, A. Heidemeier, B. Krauss, S. Knop, T. Bley, B. Petritsch (2018)
Multiple Myeloma and Dual-Energy CT: Diagnostic Accuracy of Virtual Noncalcium Technique for Detection of Bone Marrow Infiltration of the Spine and Pelvis.Radiology, 286 1
Christopher Hanrahan, C. Christensen, J. Crim (2010)
Current concepts in the evaluation of multiple myeloma with MR imaging and FDG PET/CT.Radiographics : a review publication of the Radiological Society of North America, Inc, 30 1
C Sachpekidis, J Mosebach, MT Freitag (2015)
. Application of (18)F-FDG PET and diffusion weighted imaging (DWI) in multiple myeloma: comparison of functional imaging modalitiesAm J Nucl Med Mol Imaging, 5
J. Dutoit, M. Vanderkerken, J. Anthonissen, F. Dochy, K. Verstraete (2014)
The diagnostic value of SE MRI and DWI of the spine in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myelomaEuropean Radiology, 24
D. Ippolito, Valeria Besostri, P. Bonaffini, F. Rossini, A. Lelio, S. Sironi (2013)
Diagnostic value of whole-body low-dose computed tomography (WBLDCT) in bone lesions detection in patients with multiple myeloma (MM).European journal of radiology, 82 12
G. Schmidt, M. Reiser, A. Baur‐Melnyk (2007)
Whole-body imaging of the musculoskeletal system: the value of MR imagingSkeletal Radiology, 36
D. Albano, C. Patti, R. Lagalla, M. Midiri, M. Galia (2017)
Whole‐body MRI, FDG‐PET/CT, and bone marrow biopsy, for the assessment of bone marrow involvement in patients with newly diagnosed lymphomaJournal of Magnetic Resonance Imaging, 45
A. Heidemeier, A. Thurner, C. Metz, T. Pabst, Heike Heidemeier, L. Rasche, K. Kortüm, H. Einsele, R. Grimm, E. Weiland, T. Bley (2020)
Whole-Body MRI with an Ultrahigh b-Value of 2000 s/mm2 Improves the Specificity of Diffusion-Weighted Imaging in Patients with Plasma Cell Dyscrasias.Academic radiology
G Filonzi, K Mancuso, E Zamagni (2017)
A comparison of different staging systems for multiple myeloma: can the MRI pattern play a prognostic role?AJR Am J Roentgenol, 209
L. Moulopoulos, V. Koutoulidis, J. Hillengass, E. Zamagni, J. Aquerreta, Charles Roche, S. Lentzsch, P. Moreau, M. Cavo, J. Miguel, M. Dimopoulos, S. Rajkumar, B. Durie, E. Terpos, S. Delorme (2018)
Recommendations for acquisition, interpretation and reporting of whole body low dose CT in patients with multiple myeloma and other plasma cell disorders: a report of the IMWG Bone Working GroupBlood Cancer Journal, 8
M. Wolf, F. Murray, K. Kilk, J. Hillengass, S. Delorme, C. Heiss, K. Neben, H. Goldschmidt, H. Kauczor, M. Weber (2014)
Sensitivity of whole-body CT and MRI versus projection radiography in the detection of osteolyses in patients with monoclonal plasma cell disease.European journal of radiology, 83 7
Yoshie Nonomura, M. Yasumoto, R. Yoshimura, K. Haraguchi, Sukeyuki Ito, T. Akashi, I. Ohashi (2001)
Relationship between bone marrow cellularity and apparent diffusion coefficientJournal of Magnetic Resonance Imaging, 13
B. Durie, R. Kyle, A. Belch, W. Bensinger, J. Bladé, M. Boccadoro, J. Child, R. Comenzo, B. Djulbegovic, D. Fantl, G. Gahrton, J. Harousseau, V. Hungria, D. Joshua, H. Ludwig, J. Mehta, A. Morales, G. Morgan, A. Nouel, M. Oken, R. Powles, D. Roodman, J. Miguel, K. Shimizu, S. Singhal, B. Sirohi, P. Sonneveld, G. Tricot, B. Ness (2003)
Myeloma management guidelines: a consensus report from the Scientific Advisors of the International Myeloma Foundation.The hematology journal : the official journal of the European Haematology Association, 4 6
T. Derlin, P. Bannas (2014)
Imaging of multiple myeloma: Current concepts.World journal of orthopedics, 5 3
Feng-zhen Cui, J. Cui, Shi-Lei Wang, Hong Yu, Ying-Cai Sun, Na Zhao, Sheng-Jie Cui (2016)
Signal characteristics of normal adult bone marrow in whole-body diffusion-weighted imagingActa Radiologica, 57
Vasiliki Pasoglou, N. Michoux, F. Peeters, A. Larbi, B. Tombal, Tom Selleslagh, P. Omoumi, B. Berg, F. Lecouvet (2015)
Whole-body 3D T1-weighted MR imaging in patients with prostate cancer: feasibility and evaluation in screening for metastatic disease.Radiology, 275 1
Charles Mesguich, C. Hulin, V. Latrabe, A. Lascaux, L. Bordenave, E. Hindié, G. Marit (2020)
Prospective comparison of 18-FDG PET/CT and whole-body diffusion-weighted MRI in the assessment of multiple myelomaAnnals of Hematology, 99
Lian-Ming Wu, H. Gu, Jasmine Zheng, Xiao Xu, Lin Lin, Xia Deng, Wei Zhang, Jian-rong Xu (2011)
Diagnostic value of whole‐body magnetic resonance imaging for bone metastases: a systematic review and meta‐analysisJournal of Magnetic Resonance Imaging, 34
J Hillengass, S Usmani, SV Rajkumar (2019)
International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disordersLancet Oncol, 20
C. Pawlyn, C. Pawlyn, Lucy Fowkes, S. Otero, John Jones, John Jones, K. Boyd, F. Davies, F. Davies, G. Morgan, G. Morgan, D. Collins, B. Sharma, A. Riddell, Martin Kaiser, Martin Kaiser, C. Messiou, C. Messiou (2015)
Whole-body diffusion-weighted MRI: a new gold standard for assessing disease burden in patients with multiple myeloma?Leukemia, 30
A. Lai, A. Riddell, T. Barwick, K. Boyd, A. Rockall, M. Kaiser, D. Koh, H. Saffar, Siraj Yusuf, C. Messiou (2019)
Interobserver agreement of whole-body magnetic resonance imaging is superior to whole-body computed tomography for assessing disease burden in patients with multiple myelomaEuropean Radiology, 30
BackgroundThe latest International Myeloma Working Group (IMWG) guideline recommends low-dose whole-body (WB) computed tomography (CT) as the first-line imaging technique for the initial diagnosis of plasma cell disorders.PurposeTo evaluate diagnostic performances of CT and diffusion-weighted imaging (DWI) as the first-line imaging modalities and assess misclassification rates obtained following the guideline.Material and MethodsTwo independent radiologists analyzed CT (acquired as PET/CT) and DWI (3-T; b-values = 50 and 900 s/mm2) of patients newly diagnosed with plasma cell disorder, categorizing the number of bone lesions. Diagnostic performance of CT and DWI was compared using the McNemar test, and misclassification rates were calculated with a consensus WB-MRI reading as the reference standard. Differences in lesion number categories were assessed using marginal homogeneity and kappa statistics.ResultsOf 56 patients (36 men; mean age = 63.5 years), 39 had myeloma lesions. DWI showed slightly higher sensitivity for detecting myeloma lesions (97.4%) than CT (84.6%–92.3%; P > 0.05). CT showed significantly higher specificity (88.2%) than DWI (52.9%–58.8%; P<0.05). CT had a higher additional study requirement rate than DWI (7.7%–15.4% vs. 2.6%), but a lower unnecessary treatment rate (11.8% vs. 41.2%–47.1%). Both readers showed significant differences in categorization of the number of lesions on CT compared with the reference standard (P < 0.001), and one reader showed a significant difference on DWI (P = 0.006 and 0.098).ConclusionCT interpreted according to the IMWG guideline is a diagnostically effective first-line modality with relatively high sensitivity and specificity. DWI alone may not be an acceptable first-line imaging modality because of low specificity.
Acta Radiologica – SAGE
Published: May 1, 2022
Keywords: Magnetic resonance imaging; diffusion magnetic resonance imaging; multidetector computed tomography; whole-body imaging; multiple myeloma
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.