Comparative outcomes of radiofrequency ablation for Barrett’s oesophagus with different baseline histology

Comparative outcomes of radiofrequency ablation for Barrett’s oesophagus with different... BackgroundRadiofrequency ablation (RFA) is currently recommended for dysplastic Barrett’s oesophagus (BO); however, there are limited data on treatment response when stratified by baseline histology.ObjectiveThe objective of this article is to evaluate RFA outcomes and durability for BO with different baseline histology.MethodsPatients treated with RFA between 2007 and 2017 at a single institution were retrospectively included. Outcome measures were: (a) complete remission of dysplasia (CRD) and intestinal metaplasia (CRIM) at 18 months, (b) complication rate and (c) durability of CRD and CRIM.ResultsA total of 148 patients underwent RFA, of whom 113 completed the treatment protocol (21 low-grade dysplasia (LGD), 46 high-grade dysplasia (HGD) and 46 intramucosal carcinoma (IMC)). CRD and CRIM were achieved in 94.7% and 78.8% of patients, respectively. When stratified by baseline histology, there was no significant difference in CRD between groups (LGD, 95.2%; HGD, 95.7%; and IMC, 93.5%; p = 0.89). Similarly, there was no significant difference in CRIM between groups (LGD, 71.4%; HGD, 76.1% and IMC, 87.0%; p = 0.39). CRD and CRIM durability at 24 months for LGD, HGD and IMC were 100%, 97.7% and 100% (log rank p = 0.31), and 100%, 89.0% and 95.5%, respectively (log rank p = 0.62).ConclusionBaseline histology is not a predictor of RFA response. Once CRD and CRIM are achieved, these effects are durable over time. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png United European Gastroenterology Journal SAGE

Comparative outcomes of radiofrequency ablation for Barrett’s oesophagus with different baseline histology

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Publisher
SAGE
Copyright
© Author(s) 2018
ISSN
2050-6406
eISSN
2050-6414
D.O.I.
10.1177/2050640617752183
Publisher site
See Article on Publisher Site

Abstract

BackgroundRadiofrequency ablation (RFA) is currently recommended for dysplastic Barrett’s oesophagus (BO); however, there are limited data on treatment response when stratified by baseline histology.ObjectiveThe objective of this article is to evaluate RFA outcomes and durability for BO with different baseline histology.MethodsPatients treated with RFA between 2007 and 2017 at a single institution were retrospectively included. Outcome measures were: (a) complete remission of dysplasia (CRD) and intestinal metaplasia (CRIM) at 18 months, (b) complication rate and (c) durability of CRD and CRIM.ResultsA total of 148 patients underwent RFA, of whom 113 completed the treatment protocol (21 low-grade dysplasia (LGD), 46 high-grade dysplasia (HGD) and 46 intramucosal carcinoma (IMC)). CRD and CRIM were achieved in 94.7% and 78.8% of patients, respectively. When stratified by baseline histology, there was no significant difference in CRD between groups (LGD, 95.2%; HGD, 95.7%; and IMC, 93.5%; p = 0.89). Similarly, there was no significant difference in CRIM between groups (LGD, 71.4%; HGD, 76.1% and IMC, 87.0%; p = 0.39). CRD and CRIM durability at 24 months for LGD, HGD and IMC were 100%, 97.7% and 100% (log rank p = 0.31), and 100%, 89.0% and 95.5%, respectively (log rank p = 0.62).ConclusionBaseline histology is not a predictor of RFA response. Once CRD and CRIM are achieved, these effects are durable over time.

Journal

United European Gastroenterology JournalSAGE

Published: Jun 1, 2018

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