Challenges and opportunities from the revised international consensus on ANCA testing

Challenges and opportunities from the revised international consensus on ANCA testing Editorial Annals of Clinical Biochemistry 0(0) 1–3 ! The Author(s) 2018 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/0004563218778303 journals.sagepub.com/home/acb Challenges and opportunities from the revised international consensus on ANCA testing 1,2 Stephen Holding In common with many assays of autoantibodies, MPO-ANCA antibodies. IIF has been the test of choice since the 1999 consensus statement, with PR3/ patient serum samples tested for antineutrophil cyto- MPO-ANCA reflex testing. Use of IIF according to plasmic antibodies (ANCA) are highly heterogeneous. these recommendations has transformed ANCA test- Each ANCA assay is an attempt to quantify an array ing, and most laboratories using commercial kits are of polyclonal antibodies with multiple avidities and now able to reliably categorize patients as C/P-ANCA often variable epitope and antigen specificities. positive or negative by IIF. This has been achieved by Additionally, different testing methods and platforms careful standardization of ANCA IIF testing on a commonly differ in epitope and antigen expression, and methodology proven in large multicentre clinical vali- the range of binding avidities detected. The consequen- 6–8 1,2 dation studies. ces of this are seen in comparative studies. For In contrast to IIF, IMA assays for PR3/MPO- ANCA testing, this variability has been addressed by ANCA, though http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Clinical Biochemistry: An International Journal of Biochemistry and Laboratory Medicine SAGE

Challenges and opportunities from the revised international consensus on ANCA testing

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Publisher
SAGE Publications
Copyright
© The Author(s) 2018
ISSN
0004-5632
eISSN
1758-1001
D.O.I.
10.1177/0004563218778303
Publisher site
See Article on Publisher Site

Abstract

Editorial Annals of Clinical Biochemistry 0(0) 1–3 ! The Author(s) 2018 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/0004563218778303 journals.sagepub.com/home/acb Challenges and opportunities from the revised international consensus on ANCA testing 1,2 Stephen Holding In common with many assays of autoantibodies, MPO-ANCA antibodies. IIF has been the test of choice since the 1999 consensus statement, with PR3/ patient serum samples tested for antineutrophil cyto- MPO-ANCA reflex testing. Use of IIF according to plasmic antibodies (ANCA) are highly heterogeneous. these recommendations has transformed ANCA test- Each ANCA assay is an attempt to quantify an array ing, and most laboratories using commercial kits are of polyclonal antibodies with multiple avidities and now able to reliably categorize patients as C/P-ANCA often variable epitope and antigen specificities. positive or negative by IIF. This has been achieved by Additionally, different testing methods and platforms careful standardization of ANCA IIF testing on a commonly differ in epitope and antigen expression, and methodology proven in large multicentre clinical vali- the range of binding avidities detected. The consequen- 6–8 1,2 dation studies. ces of this are seen in comparative studies. For In contrast to IIF, IMA assays for PR3/MPO- ANCA testing, this variability has been addressed by ANCA, though

Journal

Annals of Clinical Biochemistry: An International Journal of Biochemistry and Laboratory MedicineSAGE

Published: Jan 1, 2018

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