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- Publisher
- SAGE
- Copyright
- Copyright © 2019 by SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
- ISSN
- 2040-2066
- eISSN
- 2040-2066
- DOI
- 10.1177/095632029901000106
- Publisher site
- See Article on Publisher Site
Abstract
The potency and selectivity index of the AZT-phenyl phosphate derivatives in thymidine kinase (TK)-deficient T cells were substantially enhanced by introducing a single para-bromo substituent in the phenyl moiety. AZT-5′-(p-bromophenyl methoxyalaninyl phosphate) was 43-fold more potent than AZT-5′-(phenyl methoxyalaninyl phosphate) and was fivefold more potent than AZT in inhibiting human immunodeficiency virus (HIV) replication in TK-deficient CEM cells.
Journal
Antiviral Chemistry and Chemotherapy – SAGE
Published: Jun 23, 2016
Keywords: AZT derivatives,HIV,thymidine kinase-deficient T cells