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AZT-5′-(p-Bromophenyl Methoxyalaninyl Phosphate) as a Potent and Non-Toxic Anti-Human Immunodeficiency Virus Agent:

AZT-5′-(p-Bromophenyl Methoxyalaninyl Phosphate) as a Potent and Non-Toxic Anti-Human... The potency and selectivity index of the AZT-phenyl phosphate derivatives in thymidine kinase (TK)-deficient T cells were substantially enhanced by introducing a single para-bromo substituent in the phenyl moiety. AZT-5′-(p-bromophenyl methoxyalaninyl phosphate) was 43-fold more potent than AZT-5′-(phenyl methoxyalaninyl phosphate) and was fivefold more potent than AZT in inhibiting human immunodeficiency virus (HIV) replication in TK-deficient CEM cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Antiviral Chemistry and Chemotherapy SAGE

AZT-5′-(p-Bromophenyl Methoxyalaninyl Phosphate) as a Potent and Non-Toxic Anti-Human Immunodeficiency Virus Agent:

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Publisher
SAGE
Copyright
Copyright © 2019 by SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
ISSN
2040-2066
eISSN
2040-2066
DOI
10.1177/095632029901000106
Publisher site
See Article on Publisher Site

Abstract

The potency and selectivity index of the AZT-phenyl phosphate derivatives in thymidine kinase (TK)-deficient T cells were substantially enhanced by introducing a single para-bromo substituent in the phenyl moiety. AZT-5′-(p-bromophenyl methoxyalaninyl phosphate) was 43-fold more potent than AZT-5′-(phenyl methoxyalaninyl phosphate) and was fivefold more potent than AZT in inhibiting human immunodeficiency virus (HIV) replication in TK-deficient CEM cells.

Journal

Antiviral Chemistry and ChemotherapySAGE

Published: Jun 23, 2016

Keywords: AZT derivatives,HIV,thymidine kinase-deficient T cells

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