Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease

Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Therapeutic Advances in Cardiovascular Disease SAGE

Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease

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Publisher
SAGE Publications
Copyright
© The Author(s), 2018
ISSN
1753-9447
eISSN
1753-9455
D.O.I.
10.1177/1753944718773690
Publisher site
See Article on Publisher Site

Abstract

Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes.

Journal

Therapeutic Advances in Cardiovascular DiseaseSAGE

Published: Jul 1, 2018

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