Current Concepts in the Evaluation of Multiple Myeloma with MR Imaging and FDG PET/CT1

Note: This copy is for your personal non-commercial use only. To order presentation-ready copies for distribution to your colleagues or clients, contact us at www.rsna.org/rsnarights. EDUCATION EXHIBIT Current Concepts in the Evaluation of Multiple Myeloma with MR Imag- ing and FDG PET/CT CME FEATURE Christopher J. Hanrahan, MD, PhD • Carl R. Christensen, MD See accompanying Julia R. Crim, MD test at http:// www.rsna.org /education Multiple myeloma is a heterogeneous group of plasma cell neoplasms /rg_cme.html that primarily involve bone marrow but also may occur in the soft tis- LEARNING sue. Although the disease varies in its manifestations and its course, it is OBJECTIVES eventually fatal in all cases. Over the past 2 decades, signic fi ant advances FOR TEST 2 have been made in our understanding of the genetics and pathogen- After reading this article and taking esis of multiple myeloma and in its treatment. The use of magnetic reso- the test, the reader nance (MR) imaging and fluorine 18 fluorodeoxyglucose (FDG) posi - will be able to: tron emission tomography (PET) with computed tomography (CT) has ■ Describe the spectrum of plasma improved sensitivity for the detection of this disease. PET aids in the cell disorders and identification of active multiple myeloma on the basis of FDG uptake, the significance of focal myelomatous and MR imaging helps identify multiple myeloma from its inlfi tration lesions. of normal fat within the bone marrow, which occurs in characteristic ■ Recognize com- patterns that correlate with the disease stage. The increased sensitivity mon bone marrow infiltration patterns of these advanced cross-sectional imaging techniques has led to further of multiple myeloma refinement of the classic Durie and Salmon staging system. In addition, at MR imaging and FDG PET/CT and these imaging techniques allow a more reliable assessment of the disease correlate them with response to treatment with current regimens, which may include...